urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2022-21-4-78-84urmj-1037Research ArticleОБЗОР ЛИТЕРАТУРЫCOVID-19 и плаценто-ассоциированные осложнения беременности: есть ли связь?COVID-19 and placenta-associated pregnancy complications: is there any connection?https://orcid.org/0000-0003-2797-1926КудрявцеваЕ. В.KudryavtsevaE. V.

 Елена Владимировна Кудрявцева  – доктор медицинских наук,доцент 

 Екатеринбург 

  Elena V. Kudryavtseva – Doctor of Medicine, Associate Professor 

 Ekaterinburg 

elenavladpopova@yandex.ruМартиросянС. В.MartirosyanS. V.

 Сергей Валерьевич Мартиросян  – кандидат медицинских наук 

 Екатеринбург 

Sergej V. Martirosyan – MD 

 Ekaterinburg 

smart.75@list.ruУтамурадоваС. У.UtamuradovaS. U.

 Сабина Улугбековна Утамурадова  – врач-акушер-гинеколог 

 Екатеринбург 

  Sabina U. Utamuradova – obstetrician-gynecologist 

 Ekaterinburg 

utamuradovasabina@gmail.comФГБОУ ВО «Уральский государственный медицинский университет» Минздрава РоссииРоссияUral State Medical universityRussian FederationФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России; Государственное бюджетное учреждение здравоохранения Свердловской области «Екатеринбургский клинический перинатальный центр»РоссияUral State Medical university; Clinical Perinatal CenterRussian FederationГосударственное бюджетное учреждение здравоохранения Свердловской области «Екатеринбургский клинический перинатальный центр»РоссияClinical Perinatal CenterRussian Federation2022060920222147884Copyright © Кудрявцева Е.В., Мартиросян С.В., Утамурадова С.У., 20222022Кудрявцева Е.В., Мартиросян С.В., Утамурадова С.У.Kudryavtseva E.V., Martirosyan S.V., Utamuradova S.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1037

Введение. Женщины во время беременности могут быть особенно восприимчивы к инфекции SARSCoV-2, поскольку физиологические изменения затрагивают сердечно-сосудистую, дыхательную и иммунную системы организма. Несколько исследований указывает на то, что беременные, перенесшие COVID-19, находятся в группе высокого риска не только по развитию тяжелого течения инфекции, у них также повышена частота плаценто-ассоциированных осложнений беременности. Цель проведения литературного обзора – установить патогенетические взаимосвязи между COVID-19 и плаценто-ассоциированными осложнениями беременности. Материалы и методы исследования. Для анализа научной литературы использовались международные и российские наукометрические базы данных Google Sholar, ResearchGate, Pubmed, Elibrary. Результаты и обсуждение. Тяжелая форма COVID-19 тесно связана преэклампсией, преждевременными родами и другими неблагоприятными перинатальными исходами. Беременные женщины с инфекцией SARS-CoV-2 имеют более высокий риск материнской смертности, госпитализации в отделение интенсивной терапии, преждевременных родов и мертворождений. Однако в ряде случаев повышенная частота преэклампсии, наблюдаемая у матерей с SARS-CoV-2, может быть связана с ошибочным диагнозом и ятрогенными преждевременными родами, так как преэклампсия и COVID-19 могут иметь сходные симптомы. Вакцинация против COVID-19 рекомендуется во время беременности в группах высокого риска, чтобы предотвратить тяжелую материнскую заболеваемость и неблагоприятные исходы беременности и родов. Заключение. COVID-19 повышает риск плаценто-ассоциированных осложнений беременности. В ряде случаев COVID-19 имитирует клинику преэклампсии, поэтому требуется тщательная дифференциальная диагностика для снижения частоты ятрогенного преждевременного родоразрешения. Вакцинация у беременных является мерой профилактики инфекции COVID-19 и ее тяжелых форм и может опосредованно привести к снижению частоты больших акушерских синдромов.

Introduction. Women during pregnancy may be particularly susceptible to SARS-CoV-2 infection as physiological changes affect the cardiovascular, respiratory and immune systems. Several studies suggest that pregnant women who have had COVID-19 are not only at high risk for developing a severe infection, they also have an increased incidence of placental-associated pregnancy complications. The objective of this literature review was to establish pathogenetic relationships between COVID-19 and placenta-associated pregnancy complications. Materials and methods. International and Russian scientometric databases Google Sholar, ResearchGate, Pubmed, and Elibrary were used to analyze the scientific literature. Results and discussion. Severe COVID-19 is closely associated with preeclampsia, preterm birth, and other adverse perinatal outcomes. Pregnant women with SARS-CoV-2 infection are at higher risk of: maternal death, intensive care unit hospitalization, preterm birth and stillbirth. However, in some cases, the increased incidence of preeclampsia observed in mothers with SARS-CoV-2 may be related to misdiagnosis and iatrogenic preterm birth, as preeclampsia and COVID-19 may have similar symptoms. COVID-19 vaccination is recommended during pregnancy in high-risk groups to prevent severe maternal morbidity and adverse pregnancy and childbirth outcomes. Conclusion. COVID-19 increases the risk of placental-associated pregnancy complications. In some cases, COVID-19 mimics the clinical picture of preeclampsia, so careful differential diagnosis is required to reduce the incidence of iatrogenic preterm labor. Vaccination in pregnant women is a preventive measure against COVID-19 infection and its severe forms and may indirectly reduce in the incidence of major obstetric syndromes.

преэклампсияCOVID-19SARS-CoV-2вакцинацияпандемиябольшие акушерские синдромыpre-eclampsiaCOVID-19SARS-CoV-2vaccinationpandemicmajor obstetric syndromesReferencesCucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157–160. https://doi.org/10.23750/abm.v91i1.9397Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157–160. https://doi.org/10.23750/abm.v91i1.9397Дулаева Е.В., Ефимкова Е.Б., Новикова С.В. Новая коронавирусная инфекция COVID-19 и беременность. Российский вестник акушера-гинеколога. 2021;21(6):44–50. https://doi.org/10.17116/rosakush20212106144Дулаева Е.В., Ефимкова Е.Б., Новикова С.В. Новая коронавирусная инфекция COVID-19 и беременность. Российский вестник акушера-гинеколога. 2021;21(6):44–50. https://doi.org/10.17116/rosakush20212106144Wastnedge EA, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, Critchley HO. Pregnancy and COVID-19. Physiol Rev. 2021;101(1):303–318. https://doi.org/10.1152/physrev.00024.2020Wastnedge EA, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, Critchley HO. Pregnancy and COVID-19. Physiol Rev. 2021;101(1):303–318. https://doi.org/10.1152/physrev.00024.2020Mallah SI, Ghorab OK, Al-Salmi S, Abdellatif OS, Tharmaratnam T, Iskandar MA, Sefen JA, Sidhu P, Atallah B, El-Lababidi R, Al-Qahtani M. COVID-19: breaking down a global health crisis. Ann Clin Microbiol Antimicrob. 2021;20 (1):35. https://doi.org/10.1186/s12941-021-00438-7Mallah SI, Ghorab OK, Al-Salmi S, Abdellatif OS, Tharmaratnam T, Iskandar MA, Sefen JA, Sidhu P, Atallah B, El-Lababidi R, Al-Qahtani M. COVID-19: breaking down a global health crisis. Ann Clin Microbiol Antimicrob. 2021;20 (1):35. https://doi.org/10.1186/s12941-021-00438-7Chen R, Zhang S, Su S, Ye H, Shu H. Interactions Between Specific Immune Status of Pregnant Women and SARSCoV-2 Infection. Front Cell Infect Microbiol [Internet]. 2021 [cited 26.07.2022]; 11:721309. Available from: https://doi.org/10.3389/fcimb.2021.721309Chen R, Zhang S, Su S, Ye H, Shu H. Interactions Between Specific Immune Status of Pregnant Women and SARSCoV-2 Infection. Front Cell Infect Microbiol [Internet]. 2021 [cited 26.07.2022]; 11:721309. Available from: https://doi.org/10.3389/fcimb.2021.721309Kumar R, Yeni CM, Utami NA, Masand R, Asrani RK, Patel SK, Kumar A, Yatoo MI, Tiwari R, Natesan S, Vora KS, Nainu F, Bilal M, Dhawan M, Emran TB, Ahmad T, Harapan H, Dhama K. SARS-CoV-2 infection during pregnancy and pregnancyrelated conditions: Concerns, challenges, management and mitigation strategies-a narrative review. J Infect Public Health. 2021;14(7):863–875. https://doi.org/10.1016/j.jiph.2021.04.005Kumar R, Yeni CM, Utami NA, Masand R, Asrani RK, Patel SK, Kumar A, Yatoo MI, Tiwari R, Natesan S, Vora KS, Nainu F, Bilal M, Dhawan M, Emran TB, Ahmad T, Harapan H, Dhama K. SARS-CoV-2 infection during pregnancy and pregnancyrelated conditions: Concerns, challenges, management and mitigation strategies-a narrative review. J Infect Public Health. 2021;14(7):863–875. https://doi.org/10.1016/j.jiph.2021.04.005Boelig RC, Aagaard KM, Debbink MP, Shamshirsaz AA. Society for Maternal-Fetal Medicine Special Statement: COVID-19 research in pregnancy: progress and potential. Am J Obstet Gynecol. 2021;225(6):B19–B31. https://doi.org/10.1016/j.ajog.2021.08.039Boelig RC, Aagaard KM, Debbink MP, Shamshirsaz AA. Society for Maternal-Fetal Medicine Special Statement: COVID-19 research in pregnancy: progress and potential. Am J Obstet Gynecol. 2021;225(6):B19–B31. https://doi.org/10.1016/j.ajog.2021.08.039Адамян Л.В., Вечорко В.И., Конышева О.В., Харченко Э.И. Беременность и COVID-19: актуальные вопросы (обзор литературы). Проблемы репродукции. 2021;27(3):70–77. https://doi.org/https://doi.org/10.17116/repro20212703170Адамян Л.В., Вечорко В.И., Конышева О.В., Харченко Э.И. Беременность и COVID-19: актуальные вопросы (обзор литературы). Проблемы репродукции. 2021;27(3):70–77. https://doi.org/https://doi.org/10.17116/repro20212703170Romero R. Prenatal medicine: the child is the father of the man. 1996. J Matern Neonatal Med. 2009;22(8):636–639. https://doi.org/10.1080/14767050902784171Romero R. Prenatal medicine: the child is the father of the man. 1996. J Matern Neonatal Med. 2009;22(8):636–639. https://doi.org/10.1080/14767050902784171Ковалев В.В., Кудрявцева Е.В., Миляева Н.М., Беломестнов С.Р. Большие акушерские синдромы : «гордиев узел» генных сетей. Уральский медицинский журнал. 2018;(13):40–47. https://doi.org/10.25694/URMJ.2018.13.45Ковалев В.В., Кудрявцева Е.В., Миляева Н.М., Беломестнов С.Р. Большие акушерские синдромы : «гордиев узел» генных сетей. Уральский медицинский журнал. 2018;(13):40–47. https://doi.org/10.25694/URMJ.2018.13.45Wenling Y, Junchao Q, Xiao Z, Ouyang S. Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo [Internet]. 2020 [cited 26.07.2022];62:e62. Available from: https://doi.org/10.1590/s1678-9946202062062Wenling Y, Junchao Q, Xiao Z, Ouyang S. Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo [Internet]. 2020 [cited 26.07.2022];62:e62. Available from: https://doi.org/10.1590/s1678-9946202062062Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, Debenham L, Llavall AC, Dixit A, Zhou D, Balaji R, Lee SI, Qiu X, Yuan M, Coomar D, Sheikh J, Lawson H, Ansari K, van Wely M, van Leeuwen E, Kostova E, Kunst H, Khalil A, Tiberi S, Brizuela V, Broutet N, Kara E, Kim CR, Thorson A, Oladapo OT, Mofenson L, Zamora J, Thangaratinam S. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and metaanalysis. BMJ. 2020;370:m3320. https://doi.org/10.1136/bmj.m3320Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, Debenham L, Llavall AC, Dixit A, Zhou D, Balaji R, Lee SI, Qiu X, Yuan M, Coomar D, Sheikh J, Lawson H, Ansari K, van Wely M, van Leeuwen E, Kostova E, Kunst H, Khalil A, Tiberi S, Brizuela V, Broutet N, Kara E, Kim CR, Thorson A, Oladapo OT, Mofenson L, Zamora J, Thangaratinam S. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and metaanalysis. BMJ. 2020;370:m3320. https://doi.org/10.1136/bmj.m3320Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19 : методические рекомендации : утв. Минздравом России : версия 5, от 28.12.2021 [Электронный ресурс] // КонсультантПлюс : [сайт]. URL: http://www.consultant.ru/document/cons_doc_LAW_351216/?ysclid=l621hjuxfa629856120 (дата обращения: 27.07.2022).Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19 : методические рекомендации : утв. Минздравом России : версия 5, от 28.12.2021 [Электронный ресурс] // КонсультантПлюс : [сайт]. URL: http://www.consultant.ru/document/cons_doc_LAW_351216/?ysclid=l621hjuxfa629856120 (дата обращения: 27.07.2022).Narang K, Enninga EA, Gunaratne MD, Ibirogba ER, Trad AT, Elrefaei A, Theiler RN, Ruano R, Szymanski LM, Chakraborty R, Garovic VD. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review. Mayo Clin Proc. 2020;95(8):1750–1765. https://doi.org/10.1016/j.mayocp.2020.05.011Narang K, Enninga EA, Gunaratne MD, Ibirogba ER, Trad AT, Elrefaei A, Theiler RN, Ruano R, Szymanski LM, Chakraborty R, Garovic VD. SARS-CoV-2 infection and COVID-19 during pregnancy: a multidisciplinary review. Mayo Clin Proc. 2020;95(8):1750–1765. https://doi.org/10.1016/j.mayocp.2020.05.011Lai J, Romero R, Tarca AL, Iliodromiti S, Rehal A, Banerjee A, Yu C, Peeva G, Palaniappan V, Tan L, Mehta M, Nicolaides KH. SARS-CoV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose-response relationship supporting causality. Am J Obstet Gynecol. 2021;225(6):689–693.e1. https://doi.org/10.1016/j.ajog.2021.08.020Lai J, Romero R, Tarca AL, Iliodromiti S, Rehal A, Banerjee A, Yu C, Peeva G, Palaniappan V, Tan L, Mehta M, Nicolaides KH. SARS-CoV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose-response relationship supporting causality. Am J Obstet Gynecol. 2021;225(6):689–693.e1. https://doi.org/10.1016/j.ajog.2021.08.020Turpin CA, Sakyi SA, Owiredu WK, Ephraim RK, Anto EO. Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia. BMC pregnancy childbirth [Internet]. 2015 [cited 26.07.2022];15:189. Available from: https://doi.org/10.1186/s12884-015-0624-yTurpin CA, Sakyi SA, Owiredu WK, Ephraim RK, Anto EO. Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia. BMC pregnancy childbirth [Internet]. 2015 [cited 26.07.2022];15:189. Available from: https://doi.org/10.1186/s12884-015-0624-yConde-Agudelo A, Romero R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2022;226(1):68–89.e3. https://doi.org/10.1016/j.ajog.2021.07.009Conde-Agudelo A, Romero R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2022;226(1):68–89.e3. https://doi.org/10.1016/j.ajog.2021.07.009Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021;193(16):E540–E548. https://doi.org/10.1503/cmaj.202604Wei SQ, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021;193(16):E540–E548. https://doi.org/10.1503/cmaj.202604Беженарь В.Ф., Добровольская И.А., Нестеров И.М., Жейц И.М. Исходы беременности при среднетяжелых и тяжелых формах COVID-19. Эффективная фармакотерапия. 2022;18(7):12–18. https://doi.org/10.33978/2307-3586-2022-18-7-12-18Беженарь В.Ф., Добровольская И.А., Нестеров И.М., Жейц И.М. Исходы беременности при среднетяжелых и тяжелых формах COVID-19. Эффективная фармакотерапия. 2022;18(7):12–18. https://doi.org/10.33978/2307-3586-2022-18-7-12-18Armin S, Nugent K. Effects of COVID-19 infection during pregnancy. The Southwest respiratory and critical care chronicles. 2021;9(39):28–34. https://doi.org/10.12746/swrccc.v9i39.851Armin S, Nugent K. Effects of COVID-19 infection during pregnancy. The Southwest respiratory and critical care chronicles. 2021;9(39):28–34. https://doi.org/10.12746/swrccc.v9i39.851Huntley BJ, Mulder IA, Di Mascio D, Vintzileos WS, Vintzileos AM, Berghella V, Chauhan SP. Adverse Pregnancy Outcomes Among Individuals With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review and Meta-analysis. Obstet Gynecol. 2021;137(4):585–596. https://doi.org/10.1097/AOG.0000000000004320Huntley BJ, Mulder IA, Di Mascio D, Vintzileos WS, Vintzileos AM, Berghella V, Chauhan SP. Adverse Pregnancy Outcomes Among Individuals With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review and Meta-analysis. Obstet Gynecol. 2021;137(4):585–596. https://doi.org/10.1097/AOG.0000000000004320Ali Khan MM, Khan MN, Mustagir MG, Rana J, Haque MR, Rahman MM. COVID-19 infection during pregnancy: a systematic review to summarize possible symptoms, treatments, and pregnancy outcomes. MedRxiv [Preprint]. 2020 [cited 26.07.2022]: [25 p.]. Available from: https://doi.org/10.1101/2020.03.31.20049304.Ali Khan MM, Khan MN, Mustagir MG, Rana J, Haque MR, Rahman MM. COVID-19 infection during pregnancy: a systematic review to summarize possible symptoms, treatments, and pregnancy outcomes. MedRxiv [Preprint]. 2020 [cited 26.07.2022]: [25 p.]. Available from: https://doi.org/10.1101/2020.03.31.20049304.Metz TD, Clifton RG, Hughes BL, Sandoval G, Saade GR, Grobman WA, Manuck TA, Miodovnik M, Sowles A, Clark K, Gyamfi-Bannerman C, Mendez-Figueroa H, Sehdev HM, Rouse DJ, Tita AT, Bailit J, Costantine MM, Simhan HN, Macones GA. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet Gynecol. 2021;137:571–580. https://doi.org/10.1097/AOG.0000000000004339Metz TD, Clifton RG, Hughes BL, Sandoval G, Saade GR, Grobman WA, Manuck TA, Miodovnik M, Sowles A, Clark K, Gyamfi-Bannerman C, Mendez-Figueroa H, Sehdev HM, Rouse DJ, Tita AT, Bailit J, Costantine MM, Simhan HN, Macones GA. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet Gynecol. 2021;137:571–580. https://doi.org/10.1097/AOG.0000000000004339Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, Lopez-Martinez RM, Balcells J, Fernandez-Hidalgo N, Carreras E, Suy A. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127(11):1374–1380. https://doi.org/10.1111/1471-0528.16339Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, Lopez-Martinez RM, Balcells J, Fernandez-Hidalgo N, Carreras E, Suy A. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127(11):1374–1380. https://doi.org/10.1111/1471-0528.16339Sathiya R, Rajendran J, Sumathi S. COVID-19 and preeclampsia: overlapping features in pregnancy. Rambam Maimonides Med J [Internet]. 2022 [cited 26.07.2022];13(1):e0007. Available from: https://doi.org/10.5041/RMMJ.10464Sathiya R, Rajendran J, Sumathi S. COVID-19 and preeclampsia: overlapping features in pregnancy. Rambam Maimonides Med J [Internet]. 2022 [cited 26.07.2022];13(1):e0007. Available from: https://doi.org/10.5041/RMMJ.10464Leavitt AO, Li Q, Chan ED. Re: Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study: Common pathophysiology of pre-eclampsia and severe COVID-19? BJOG. 2021;128(3):618–619. https://doi.org/10.1111/1471-0528.16584Leavitt AO, Li Q, Chan ED. Re: Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study: Common pathophysiology of pre-eclampsia and severe COVID-19? BJOG. 2021;128(3):618–619. https://doi.org/10.1111/1471-0528.16584Makatsariya A, Slukhanchuk E, Bitsadze V, Khizroeva J, Tretyakova M, Tsibizova V, Dobryakov A, Elalamy I, Gris JC. COVID-19, neutrophil extracellular traps and vascular complications in obstetric practice. J Perinat Med. 2020;48(9):985–994. https://doi.org/10.1515/jpm-2020-0280Makatsariya A, Slukhanchuk E, Bitsadze V, Khizroeva J, Tretyakova M, Tsibizova V, Dobryakov A, Elalamy I, Gris JC. COVID-19, neutrophil extracellular traps and vascular complications in obstetric practice. J Perinat Med. 2020;48(9):985–994. https://doi.org/10.1515/jpm-2020-0280de Loyola MB, Dos Reis TTA, de Oliveira GXLM, da Fonseca Palmeira J, Argañaraz GA, Argañaraz ER. Alpha-1-antitrypsin: A possible host protective factor against Covid-19. Rev Med Virol [Internet]. 2021 [cited 26.07.2022];31(2):e2157. Available from: https://doi.org/10.1002/rmv.2157de Loyola MB, Dos Reis TTA, de Oliveira GXLM, da Fonseca Palmeira J, Argañaraz GA, Argañaraz ER. Alpha-1-antitrypsin: A possible host protective factor against Covid-19. Rev Med Virol [Internet]. 2021 [cited 26.07.2022];31(2):e2157. Available from: https://doi.org/10.1002/rmv.2157Feng Y, Wang N, Xu J, Zou J, Liang X, Liu H, Chen Y. Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4. Oncotarget [Internet]. 2017 [cited 26.07.2022];8(68):113002–113012. Available from: https://doi.org/10.18632/oncotarget.22949Feng Y, Wang N, Xu J, Zou J, Liang X, Liu H, Chen Y. Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4. Oncotarget [Internet]. 2017 [cited 26.07.2022];8(68):113002–113012. Available from: https://doi.org/10.18632/oncotarget.22949Feng Y, Hu L, Xu Q, Yuan H, Ba L, He Y, Che H. Cytoprotective role of alpha-1 antitrypsin in vascular endothelial cell under hypoxia/reoxygenation condition. J Cardiovasc Pharmacol. 2015;66(1):96–107. https://doi.org/10.1097/FJC.0000000000000250Feng Y, Hu L, Xu Q, Yuan H, Ba L, He Y, Che H. Cytoprotective role of alpha-1 antitrypsin in vascular endothelial cell under hypoxia/reoxygenation condition. J Cardiovasc Pharmacol. 2015;66(1):96–107. https://doi.org/10.1097/FJC.0000000000000250Marín R, Chiarello DI, Abad C, Rojas D, Toledo F, Sobrevia L. Oxidative stress and mitochondrial dysfunction in earlyonset and late-onset preeclampsia. Biochim Biophys Acta Mol Basis Dis. 2020;1866(12):165961. https://doi.org/https://doi.org/10.1016/j.bbadis.2020.165961Marín R, Chiarello DI, Abad C, Rojas D, Toledo F, Sobrevia L. Oxidative stress and mitochondrial dysfunction in earlyonset and late-onset preeclampsia. Biochim Biophys Acta Mol Basis Dis. 2020;1866(12):165961. https://doi.org/https://doi.org/10.1016/j.bbadis.2020.165961Agostinis C, Mangogna A, Balduit A, Aghamajidi A, Ricci G, Kishore U, Bulla R. COVID-19, pre-eclampsia, and complement system. Front Immunol [Internet]. 2021 [cited 26.07.2022];12:775168. Available from: https://doi.org/10.3389/fimmu.2021.775168Agostinis C, Mangogna A, Balduit A, Aghamajidi A, Ricci G, Kishore U, Bulla R. COVID-19, pre-eclampsia, and complement system. Front Immunol [Internet]. 2021 [cited 26.07.2022];12:775168. Available from: https://doi.org/10.3389/fimmu.2021.775168Lipkind HS, Vazquez-Benitez G, DeSilva M, Vesco KK, Ackerman-Banks C, Zhu J, Boyce TG, Daley MF, Fuller CC, Getahun D, Irving SA, Jackson LA, Williams JT, Zerbo O, McNeil MM, Olson CK, Weintraub E, Kharbanda EO. Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birth - eight integrated health care organizations, United States, December 15, 2020-July 22, 2021. MMWR Morb Mortal Wkly Rep. 2022;71(1):26–30. https://doi.org/10.15585/mmwr.mm7101e1Lipkind HS, Vazquez-Benitez G, DeSilva M, Vesco KK, Ackerman-Banks C, Zhu J, Boyce TG, Daley MF, Fuller CC, Getahun D, Irving SA, Jackson LA, Williams JT, Zerbo O, McNeil MM, Olson CK, Weintraub E, Kharbanda EO. Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birth - eight integrated health care organizations, United States, December 15, 2020-July 22, 2021. MMWR Morb Mortal Wkly Rep. 2022;71(1):26–30. https://doi.org/10.15585/mmwr.mm7101e1Holness N, Powell-Young Y, Torres E, DuBois S, Giger J. Covid-19, pregnancy, and vaccinations. J Natl Black Nurses Assoc 2021;32(1):1–9.Holness N, Powell-Young Y, Torres E, DuBois S, Giger J. Covid-19, pregnancy, and vaccinations. J Natl Black Nurses Assoc 2021;32(1):1–9.Logunov DY, Dolzhikova IV, Shcheblyakov DV, Tukhvatulin AI, Zubkova OV, Dzharullaeva AS, Kovyrshina AV, Lubenets NL, Grousova DM, Erokhova AS, Botikov AG, Izhaeva FM, Popova O, Ozharovskaya TA, Esmagambetov IB, Favorskaya IA, Zrelkin DI, Voronina DV, Shcherbinin DN, Semikhin AS, Simakova YV, Tokarskaya EA, Egorova DA, Shmarov MM, Nikitenko NA, Gushchin VA, Smolyarchuk EA, Zyryanov SK, Borisevich SV, Naroditsky BS, Gintsburg AL. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet. 2021;397(10275):671–681. https://doi.org/10.1016/S0140-6736(21)00234-8Logunov DY, Dolzhikova IV, Shcheblyakov DV, Tukhvatulin AI, Zubkova OV, Dzharullaeva AS, Kovyrshina AV, Lubenets NL, Grousova DM, Erokhova AS, Botikov AG, Izhaeva FM, Popova O, Ozharovskaya TA, Esmagambetov IB, Favorskaya IA, Zrelkin DI, Voronina DV, Shcherbinin DN, Semikhin AS, Simakova YV, Tokarskaya EA, Egorova DA, Shmarov MM, Nikitenko NA, Gushchin VA, Smolyarchuk EA, Zyryanov SK, Borisevich SV, Naroditsky BS, Gintsburg AL. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet. 2021;397(10275):671–681. https://doi.org/10.1016/S0140-6736(21)00234-8Magon N, Prasad S, Mahato C, Sharma JB. COVID-19 vaccine and pregnancy: A safety weapon against pandemic. Taiwan J Obstet Gynecol. 2022;61(2):201–209. https://doi.org/10.1016/j.tjog.2022.02.005Magon N, Prasad S, Mahato C, Sharma JB. COVID-19 vaccine and pregnancy: A safety weapon against pandemic. Taiwan J Obstet Gynecol. 2022;61(2):201–209. https://doi.org/10.1016/j.tjog.2022.02.005Theiler R, Wick M, Mehta R, Weaver A, Virk A, Swift M. Pregnancy and birth outcomes after SARS-CoV-2 vaccination in pregnancy. Am J Obstet Gynecol MFM [Internet]. 2021 [cited 26.07.2022];3(6):100467. Available from: https://doi.org/10.1016/j.ajogmf.2021.100467Theiler R, Wick M, Mehta R, Weaver A, Virk A, Swift M. Pregnancy and birth outcomes after SARS-CoV-2 vaccination in pregnancy. Am J Obstet Gynecol MFM [Internet]. 2021 [cited 26.07.2022];3(6):100467. Available from: https://doi.org/10.1016/j.ajogmf.2021.100467Harsini PA, Imani G, hamzehie S, Jeihooni AK. Covid 19 and pregnancy vaccination: challenges and concerns. International Journal of Epidemiology and Public Health Research [Internet]. 2022 [cited 26.07.2022];2(1). Available from: https://aditum.org/images/article/1641365939IJEPHR_Galley_Proof.pdfHarsini PA, Imani G, hamzehie S, Jeihooni AK. Covid 19 and pregnancy vaccination: challenges and concerns. International Journal of Epidemiology and Public Health Research [Internet]. 2022 [cited 26.07.2022];2(1). Available from: https://aditum.org/images/article/1641365939IJEPHR_Galley_Proof.pdfAltaf F, Farrukh A, Chavan S. Pregnancy and COVID-19: A Review. Int J Heal Sci Res [Internet]. 2022 [cited 26.07.2022];12 (2):271–279. Available from: https://doi.org/10.52403/ijhsr.20220238 электронныйAltaf F, Farrukh A, Chavan S. Pregnancy and COVID-19: A Review. Int J Heal Sci Res [Internet]. 2022 [cited 26.07.2022];12 (2):271–279. Available from: https://doi.org/10.52403/ijhsr.20220238 электронныйDi Mascio D, Buca D, Berghella V, Khalil A, Rizzo G, Odibo A, Saccone G, Galindo A, Liberati M, D'Antonio F. Counseling in maternal-fetal medicine: SARS-CoV-2 infection in pregnancy. Ultrasound Obstet Gynecol. 2021;57(5):687–697. https://doi.org/10.1002/uog.23628.Di Mascio D, Buca D, Berghella V, Khalil A, Rizzo G, Odibo A, Saccone G, Galindo A, Liberati M, D'Antonio F. Counseling in maternal-fetal medicine: SARS-CoV-2 infection in pregnancy. Ultrasound Obstet Gynecol. 2021;57(5):687–697. https://doi.org/10.1002/uog.23628.Адамян Л.В., Филиппов О.С., Степанян А.А., Азнаурова Я.Б., Конышева О.В. Вакцинация против COVID-19 при беременности (обзор литературы). Проблемы репродукции. 2021;27(5): 13–24. https://doi.org/10.17116/repro2021270325Адамян Л.В., Филиппов О.С., Степанян А.А., Азнаурова Я.Б., Конышева О.В. Вакцинация против COVID-19 при беременности (обзор литературы). Проблемы репродукции. 2021;27(5): 13–24. https://doi.org/10.17116/repro2021270325

The authors declare that there are no conflicts of interest present.