urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2022-21-5-94-101urmj-1090Research ArticleПАТОФИЗИОЛОГИЯPATHOPHYSIOLOGYГеропротекторные свойства фукоксантинаGeroprotective properties of fucoxanthinГребневД. Ю.GrebnevD. Yu.

Дмитрий Юрьевич Гребнев, доктор медицинских наук

Екатеринбург

Dmitry Yu. Grebnev, Doctor of Science (Medicine), Associate Professor

Ekaterinburg

dr-grebnev77@mail.ruМаклаковаИ. Ю.MaklakovaI. Yu.

Ирина Юрьевна Маклакова, доктор медицинских наук

Екатеринбург

Irina Yu. Maklakova, Doctor of Science (Medicine), Associate Professor

Ekaterinburg

makliu@mail.ruТитоваД. И.TitovaD. I.

Диана Ильинична Титова, студентка

Екатеринбург

Diana I. Titova, Student

Ekaterinburg

titova23@inbox.ruПермяковН. С.PermyakovN. S.

Никита Сергеевич Пермяков, студент

Екатеринбург

Nikita S. Permyakov, Student

Ekaterinburg

drakewilson1337@yandex.ruУральский государственный медицинский университет; Институт медицинских клеточных технологийРоссияUral State Medical University; Institute of Medical Cell TechnologiesRussian FederationУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation20220511202221594101Copyright © Гребнев Д.Ю., Маклакова И.Ю., Титова Д.И., Пермяков Н.С., 20222022Гребнев Д.Ю., Маклакова И.Ю., Титова Д.И., Пермяков Н.С.Grebnev D.Y., Maklakova I.Y., Titova D.I., Permyakov N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1090

Введение. Фукоксантин – один из основных представителей морских каротиноидов, проявляющий широкий спектр биологической активности, включая геропротекторный эффект. Самым частым источником фукоксантина в пищевой промышленности являются диатомовые водоросли (например, Phaeodactylum tricornutum). Цель исследования – обобщение и анализ данных о механизмах геропротекторного действия фукоксантина. Материалы и методы. Представлен анализ публикаций научных исследований, размещенных в базах данных PubMed, E-Library, Google Scholar, ScienceDirect, UpToDate, а также обзор научной литературы за период с 2017 по 2022 год. Отражены результаты применения фукоксантина на культурах клеток животных и человека, где препарат проявил себя в качестве потенциального геропротектора. Критерии включения: приоритет отдавался обзорным и оригинальным статьям, в которых были представлены данные о результатах применения фукоксантина. Ключевые слова при поиске публикаций: фукоксантин, геропротектор, окислительный стресс, гормезис. Результаты и обсуждение. При углубленном изучении структуры фукоксантина была выяснена его фармакодинамика как потенциального лекарственного препарата. Множество положительных фармакологических эффектов фукоксантин реализует благодаря наличию в химической структуре алленовой связи. Механизмы фукоксантина оказывают влияние на окислительный стресс и старение организма на разных уровнях организации (молекулярном, клеточном, тканевом, органном). Ухудшение зрения нередко становится проблемой пожилых людей и является одним из свойств старения организма. Гипотеза о том, что фукоксантин реализует геропротекторный эффект за счет цитопротекторного потенциала при окислительном стрессе приобретает наибольшую популярность. Геропротекторное действие фукоксантина на весь организм связано непосредственно с дифференциальной экспрессией генов и изменениями активности молекулярных путей. При транскрипторном анализе эффектов фукоксантина очевидна активация механизмов, связанных с гормезисом. Заключение. Исследования показали эффективность использования фукоксантина в качестве терапевтического средства для лечения заболеваний, ассоциированных с процессом старения.

Introduction. Fucoxanthin is one of the main representatives of marine carotenoids with a wide range of biological activities, including a geroprotective effect. The most common source of fucoxanthin in the food industry is diatomic algae (e.g., Phaeodactylum tricornutum). The aim of the work was to summarize and analyze the data on the mechanisms of geroprotective action of fucoxanthin. Materials and Methods. An analysis of scientific research publications from PubMed, E-Library, Google Scholar, ScienceDirect, UpToDate databases is presented, as well as a review of scientific literature for the period from 2017 to 2022. The results of fucoxanthin use on animal and human cell cultures, where the drug proved to be a potential geroprotector, are reflected. Inclusion criteria: priority was given to review and original articles that presented data on the results of fucoxanthin application. Key words in the search for publications: fucoxanthin, geroprotector, oxidative stress, hormesis. Results and Discussion. In-depth study of fucoxanthin structure revealed its pharmacodynamics as a potential drug. Many positive pharmacological effects of fucoxanthin are realized due to the presence of an allene bond in the chemical structure. The mechanisms of fucoxanthin influence oxidative stress and aging at different levels of organization (molecular, cellular, tissue, organ). Deterioration of vision is often a problem of the elderly and is one of the properties of the aging organism. The hypothesis that fucoxanthin realizes a geroprotective effect due to its cytoprotective potential under oxidative stress is the most popular. The geroprotective effect of fucoxanthin on the whole organism is directly related to the differential expression of genes and changes in the activity of molecular pathways. In the transcriptome analysis of fucoxanthin effects, the activation of mechanisms related to hormesis is evident. Conclusion. Studies have shown the effectiveness of fucoxanthin as a therapeutic agent for the treatment of diseases associated with the aging process.

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The authors declare that there are no conflicts of interest present.