urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2023-22-1-96-103urmj-1198Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsВклад микробиоты полости матки в развитие патологических процессов эндометрияContribution of the uterine cavity microbiota to the development of pathological endometrial processeshttps://orcid.org/0000-0001-5561-3072ИсламидиД. К.IslamidiD. K.

Диана Константиновна Исламиди – кандидат медицинских наук 

Екатеринбург

Diana K. Islamidi – Ph.D. in medicine 

Ekaterinburg

dishader@yandex.ruБелыхН. С.BelyhN. S.

Наталья Сергеевна Белых – аспирант 

Екатеринбург

Natal'ja S. Belyh – Postgraduate student 

Ekaterinburg

Nsb24@bk.ruhttps://orcid.org/0000-0001-8640-8418КовалевВ. В.KovalevV. V.

Владислав Викторович Ковалев – доктор медицинских наук, профессор 

Екатеринбург

Vladislav V. Kovalev – Doctor of Science (Medicine), Professor 

Ekaterinburg

vvkovalev55@gmail.comМиляеваН. М.MilyaevaN. M.

Наталья Маратовна Миляева – доктор медицинских наук 

Екатеринбург

Natal'ja M. Milyaeva – Doctor of Science (Medicine) 

Ekaterinburg

soneta64@rambler.ruУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation20231703202322196103Copyright © Исламиди Д.К., Белых Н.С., Ковалев В.В., Миляева Н.М., 20232023Исламиди Д.К., Белых Н.С., Ковалев В.В., Миляева Н.М.Islamidi D.K., Belyh N.S., Kovalev V.V., Milyaeva N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1198

Введение. В структуре гинекологической заболеваемости внутриматочная патология занимает лидирующие позиции из-за высокой частоты встречаемости, негативного влияния на репродуктивное здоровье женщины и высокой частоты рецидивов данных заболеваний . Патология эндометрия многочисленна и включает в себя гиперплазию и полипы эндометрия, рак эндометрия, аномальные маточные кровотечения и дисменорею, эндометриоз тела матки и синдром Ашермана. Особенно актуальны патологические изменения эндометрия у женщин с репродуктивными проблемами, такие как бесплодие, привычное невынашивание и повторные попытки неудач в программах ВРТ. Цель работы – основываясь на данных современной отечественной и зарубежной научной литературы, оценить вклад микробиоты эндометрия в развитии патологических процессов эндометрия и определить возможные возбудители для развития данного процесса. Материалы и методы. Анализ и систематизация данных проводился на основе научных публикаций , размещенных в базах данных PubMed, Google Scholar, Scopus, e-Library за период 2010–2021 гг. Для итогового научного обзора было отобрано 65 источников. Результаты и обсуждение. В статье представлены данные результатов исследований роли микробиоты полости матки и ее вклад в развитие патологии эндометрия – такой как полип и гиперплазия эндометрия, аденомиоз и маточные кровотечения, бесплодие и внутриматочные синехии. Коррекция измененной микробиоты открывает новое понимание развития заболеваний матки и новые возможности терапии. Заключение. Многочисленные исследования микробиоты полости матки показывают ее несомненную роль в развитии патологии полости матки. Однако полученные данные весьма противоречивые. Дальней шее исследование микробиоты матки необходимо для более глубокого понимания патогенеза патологических процессов эндометрия.

Introduction

Introduction. In the structure of gynecological morbidity intrauterine pathology occupies a leading position because of its high frequency and negative impact on the reproductive health of a woman. Endometrial pathology is numerous and includes endometrial hyperplasia and polyps, endometrial cancer, abnormal uterine bleeding and dysmenorrhea, endometriosis and Asherman's syndrome. Pathological changes of the endometrium in women with reproductive problems, such as infertility, habitual miscarriage, are particularly relevant.

The aim of the work is to estimate the contribution of endometrial microbiota in the development of endometrial pathological processes and identify possible pathogens for the development of this process on the basis of scientific literature data.

Materials and methods

Materials and methods. Data analysis and systematization were performed on the basis of scientific publications in the PubMed, Google scholar, and Scopus databases for the period 2010–2021. For the final scientific review 65 sources were selected.

Results and discussion

Results and discussion. This article presents findings on the role of the uterine cavity microbiota and its contribution to endometrial pathology such as endometrial polyps and hyperplasia, adenomyosis and uterine bleeding, infertility and intrauterine synechiae. The correction of an altered microbiota opens up new insights into the development of uterine diseases and new therapeutic options.

Conclusion

Conclusion. Numerous studies of the uterine cavity microbiota show its undoubted role in the development of uterine cavity pathology. However, the data obtained are quite contradictory. Further study of the uterine microbiota is necessary for a deeper understanding of the pathogenesis of endometrial pathological processes.

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The authors declare that there are no conflicts of interest present.