urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2023-22-1-104-110urmj-1199Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsПостковидный мышечносуставной синдром и связь COVID-19 с ревматоидным артритомPost-COVID musculo-articular syndrome and COVID-19 association with rheumatoid arthritishttps://orcid.org/0000-0002-6129-0625КамышниковаЛ. А.KamyshnikovaL. A.

Людмила Александровна Камышникова – кандидат медицинских наук, доцент

Белгород

Lyudmila A. Kamyshnikova – Ph.D. in medicine, Associate Professor 

Belgorod

kamyshnikova@bsu.edu.ruhttps://orcid.org/0000-0002-3106-8900ПисанкинаД. С.PisankinaD. S.

Дарья Сергеевна Писанкина – студент 

Белгород

Darya S. Pisankina – Student 

Belgorod

1300161@bsu.edu.ruhttps://orcid.org/0000-0002-3456-4782ПаюдисА. Н.PayudisA. N.

Алексей Николаевич Паюдис – аспирант 

Белгород

Aleksey N. Payudis – Postgraduate student 

Belgorod

payudis@bsu.edu.ruhttps://orcid.org/0000-0001-9958-2917ПавловаЮ. С.PavlovaYu. S.

Юлия Станиславовна Павлова – аспирант 

Белгород

Yuliya S. Pavlova – Postgraduate student 

Belgorod

pavlova_yus@bsu.edu.ruhttps://orcid.org/0000-0002-8331-6873БолховитинаО. А.BolkhovitinaO. A.

Ольга Александровна Болховитина – кандидат медицинских наук 

Белгород

Olga A. Bolkhovitina – Ph.D. in medicine 

Belgorod

bolkhovitina_o@bsu.edu.ruБелгородский государственный национальный исследовательский университетРоссияBelgorod National Research UniversityRussian Federation202317032023221104110Copyright © Камышникова Л.А., Писанкина Д.С., Паюдис А.Н., Павлова Ю.С., Болховитина О.А., 20232023Камышникова Л.А., Писанкина Д.С., Паюдис А.Н., Павлова Ю.С., Болховитина О.А.Kamyshnikova L.A., Pisankina D.S., Payudis A.N., Pavlova Y.S., Bolkhovitina O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1199

Введение. После возникновения пандемии COVID-19 появилось большое количество данных по разнообразию постковидной симптоматики, в том числе наличию мышечно-суставного синдрома. Цель работы – анализ современных литературных данных по распространенности мышечно-суставного синдрома и изучению связи перенесенной коронавирусной инфекции с развитием ревматоидного артрита. Материалы и методы. Проведен поиск статей в наукометрических базах PubMed, Medline, Google Scholar (2020–2022 гг.) по ключевым словам: post-covid syndrome, muscular articular syndrome или muscle and joint pain, COVID-19, SARS-CoV-2, rheumatoid arthritis. Най дено 622 статьи, в которых эти слова встречались в тексте. Далее 497 статей были исключены как несоответствующие теме исследования. При изучении оставшихся статей особое внимание уделялось появлению мышечно-суставного синдрома после перенесенной инфекции COVID-19 и наличию связи с ревматоидным артритом. Результаты и обсуждение. Имеются работы с описанием мышечно-суставного болевого синдрома и случаев появления антител к циклическому цитруллинированному пептиду (АЦЦП) после перенесенного COVID-19, что косвенно может свидетельствовать о развитии ревматоидного артрита у этих больных. Исследования отражают повышение аутореактивности иммунной системы организма при COVID-19, заключающееся в повышении титров антинуклеарных антител, антикардиолипиновых антител, АЦЦП, ревматоидного фактора. В ряде статей представлены результаты связи между заражением COVID-19 и появлением или обострением ревматоидного артрита. Обсуждается несколько механизмов, предполагаемо приводящим к возникновению постковидного ревматоидного артрита: индукция коронавирусом избыточного синтеза ангиотензина II, который повышает экспрессию воспалительных цитокинов, хемокинов и продукцию активных форм кислорода; активация провоспалительных субпопуляций Т-клеток; активация Toll-подобного рецептора-7 синовиальных оболочек, инициирующего воспалительный ответ; «цитокиновый шторм». Заключение. Выявлен большой процент (от 15 до 47,7 %) случаев возникновения мышечно-суставного поражения после перенесенного COVID-19. В ряде статей отражена связь между заражением COVID-19 и появлением или обострением ревматоидного артрита, однако по данному вопросу еще продолжаются обсуждения, что диктует необходимость проведения крупномасштабных исследований , специально посвященных изучению данной связи.

Introduction. Since the COVID-19 pandemic, there has been a great deal of evidence for a variety of post-COVID symptoms, including the presence of a musculo-articular syndrome. The aim of the study was to analyze the current literature data on the prevalence of musculo-articular syndrome and to study the association of coronavirus infection with the development of rheumatoid arthritis. Materials and methods. We searched PubMed, Medline, and Google Scholar (2020-2022) for articles using the following keywords: post-covid syndrome, muscular articular syndrome or muscle and joint pain, COVID-19, SARS-CoV-2, rheumatoid arthritis. We found 622 articles in which these words appeared in the text of the article. Further, 497 articles were excluded as irrelevant to the topic of the study. During the study of the remaining articles, special attention was paid to the occurrence of musculo-articular syndrome after COVID-19 infection and the association with rheumatoid arthritis. Results and discussion. There are studies describing musculo-articular pain syndrome and cases of antibodies to cyclic citrullinated peptide (ACCP) after COVID-19, which may indirectly indicate the development of rheumatoid arthritis in these patients. Studies reflect the increased autoreactivity of the immune system in COVID-19, consisting in increased titers of antinuclear antibodies, anti-cardiolipin antibodies, ACCP, and rheumatoid factor. A number of articles have presented results on the association between COVID-19 infection and the appearance, or exacerbation, of rheumatoid arthritis. Several mechanisms are discussed, presumably leading to the occurrence of post-COVID rheumatoid arthritis: induction by coronavirus of excess synthesis of angiotensin II, which increases the expression of inflammatory cytokines, chemokines and production of reactive oxygen species; activation of proinflammatory T-cell subpopulations; activation of Toll-like receptor-7 synovial membrane triggering the inflammatory response; "cytokine storm". Conclusion. A high percentage (from 15 to 47.7 %) of cases of musculo-articular lesions after COVID-19 infection has been identified. A number of articles have reported an association between COVID-19 infection and the onset, or exacerbation, of rheumatoid arthritis, but the issue is still under discussion, which necessitates large-scale studies specifically devoted to examining this association.

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The authors declare that there are no conflicts of interest present.