urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2023-22-5-123-130urmj-1337Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsСостояние репродуктивной системы у мужчин после заражения коронавирусом и вакцинацииReproductive system status in men after coronavirus infection and vaccinationhttps://orcid.org/0009-0004-8176-8384МатарХ. Т. Дж.MatarKh. T.Dzh.

Хасан Т. Дж. Матар, аспирант

Москва

Хасан Т. Дж. Матар, Postgraduate Student

Moscov

Dr.urologist.hasan@mail.ruhttps://orcid.org/0000-0002-0830-6405ЭштевешГ. М.В.EstevesG. M.V.

Гарсиа Мпака Виторино Эштевеш, аспирант

Москва

Garcia M. V. Esteves, Postgraduate Student

Moscov

garciaesteves1989@gmail.comРоссиийский университет дружбы народов имени Патриса ЛумумбыРоссияPeoples' Friendship University of Russia named after Patrice LumumbaRussian Federation202327102023225123130Copyright © Матар Х.Т., Эштевеш Г.М., 20232023Матар Х.Т., Эштевеш Г.М.Matar K.T., Esteves G.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1337Введение

Введение. Пандемия COVID-19 стала серьезной проблемой для системы здравоохранения России и всего мира, так как патогенное влияние возбудителя может вызывать систематический круг осложнений в организме, особенно в репродуктивной системе.

Цель работы – на основе анализа данных литературы определить состояние репродуктивной системы у мужчин после заражения коронавирусом и вакцинации против коронавирусной инфекции.

Материалы и методы

Материалы и методы. Поиск работ о состоянии репродуктивной системы у мужчин после заражения коронавирусом и вакцинации был проведен в базах данных PubMed, Medline, EMBASE и в электронной библиотеке eLibrary.ru.

Результаты

Результаты. На репродуктивную способность пациентов мужского пола, переболевших COVID-19, оказывают воздействие многочисленные факторы: статус общего здоровья, активность ренин-ангиотензин-альдостероновой системы, развитие системного воспалительного ответа, активация процессов липоперокисления и другие. Данные изменения вызывают воспалительный процесс в тканях репродуктивной системы, секрецию провоспалительных цитокинов, дисбаланс антиоксидантной системы, формирование окислительного стресса, поражение клеток Лейдига и Сертоли, формирование репродуктивной недостаточности и бесплодие.

Обсуждение

Обсуждение. Подтверждена патогенетическая роль SARS-CoV-2 в развитии репродуктивной депрессии у мужчин с коронавирусной инфекцией, которая оказывает длительное, негативное и стойкое воздействие на состояние гемодинамики тестикул, уровень общего тестостерона в крови и параметры эякулята.

Заключение

Заключение. Результаты опубликованных исследований свидетельствуют об ухудшении состояния репродуктивной системы у мужчин после заражения коронавирусом.

Introduction The COVID-19 pandemic is a serious problem for the health care system in Russia and worldwide, as the pathogenic influence of the pathogen can cause a systematic range of complications in the body, especially in the reproductive system.

The aim of the work was to determine the state of the reproductive system in men after coronavirus infection and vaccination based on the analysis of literature data.

Materials and methods The search for papers on the state of the reproductive system in men after coronavirus infection and vaccination was conducted in PubMed, Medline, EMBASE and eLibrary.ru databases.

Results The reproductive capacity of male patients who have undergone COVID-19 is affected by numerous factors: general health status, activity of the renin-angiotensin-aldosterone system, development of systemic inflammatory response, activation of lipoperoxidation processes, etc. This changes cause inflammatory response in the tissues of the reproductive system, secretion of pro-inflammatory cytokines, imbalance of the antioxidant system, formation of oxidative stress, damage to Leydig and Sertoli cells, formation of reproductive insufficiency and infertility.

Discussion The pathogenetic role of SARS-CoV-2 in the development of reproductive depression in men with coronavirus infection, which has a prolonged, negative and persistent effect on the state of testicular hemodynamics, the level of total testosterone in blood and ejaculate parameters, was confirmed.

Conclusion The results of the study suggest a deterioration of the reproductive system in men following coronavirus infection.

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The authors declare that there are no conflicts of interest present.