urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/2071-5943-2023-22-5-131-139urmj-1338Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsНовые перспективы применения мелатонина при менопаузальном метаболическом синдромеNew perspectives on the use of melatonin in menopausal metabolic syndromehttps://orcid.org/0000-0002-4994-6265ДаниловаМ. В.DanilovaM. V.

Марина Валерьевна Данилова, аспирант кафедры акушерства и гинекологии

Челябинск

Marina V. Danilova, Postgraduate Student of the Department of Obstetrics and Gynecology

Chelyabinsk

danilova-mv@bk.ruhttps://orcid.org/0000-0002-9644-0216УсольцеваЕ. Н.UsoltsevaE. N.

Елена Николаевна Усольцева, доктор медицинских наук, доцент кафедры акушерства и гинекологии

Челябинск

Elena N. Usoltseva, Doctor of Science (Medicine), Associate Professor of the Department of Obstetrics and Gynecology

Chelyabinsk

elena-usoltseva@yandex.ruЮжно-Уральский государственный медицинский университетРоссияSouth Ural State Medical UniversityRussian Federation202327102023225131139Copyright © Данилова М.В., Усольцева Е.Н., 20232023Данилова М.В., Усольцева Е.Н.Danilova M.V., Usoltseva E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1338Введение

Введение. Метаболический синдром представляет собой комплекс нарушений, включающих абдоминальное ожирение, нарушение толерантности к глюкозе, дислипидемию и артериальную гипертензию. Антиоксидантные и противовоспалительные свойства гормона эпифиза мелатонина имеют большое значение для сохранения гомеостаза организма. Потенциально мелатонин может быть безопасным и эффективным средством в комплексном лечении женщин с менопаузальным метаболическим синдромом.

Цель работы – определить перспективы применения гормона эпифиза мелатонина в комплексном лечении менопаузального метаболического синдрома на основании анализа научных публикаций.

Материал и методы

Материал и методы. В обзор включены данные исследований о влиянии мелатонина (МТ) на компоненты метаболического синдрома у женщин в перии постменопаузе. Поиск источников проведен за период 2016–2023 гг. в международных базах данных Medline, Scopus, Web of Science и российской научной электронной библиотеке eLibrary по поисковым словам и словосочетаниям: melatonin, menopause, perimenopause, metabolic syndrome, obesity, insulin resistance, dyslipidemia, arterial hypertension, мелатонин, менопауза, перименопауза, метаболический синдром, ожирение, инсулинорезистентность, дислипидемия, артериальная гипертензия.

Результаты и обсуждение

Результаты и обсуждение. Проведенный анализ литературных данных показал ряд преимуществ влияния препаратов экзогенного МТ на отдельные компоненты метаболического синдрома, но некоторые результаты были противоречивыми. Обнаружены научные доказательства влияния МТ на антропометрические показатели, маркеры гомеостаза глюкозы, гемодинамические показатели и признаки воспалительного ответа организма, а также разнонаправленного влияния на липидный профиль.

Заключение

Заключение. Учитывая многофункциональность и безопасность препаратов экзогенного МТ, следует рассмотреть возможность его применения в комплексной терапии менопаузального метаболического синдрома.

Introduction Metabolic syndrome is a complex of disorders including abdominal obesity, impaired glucose tolerance, dyslipidemia, and arterial hypertension. Antioxidant and anti-inflammatory properties of the pineal hormone melatonin are of great importance for preserving body homeostasis, and potentially melatonin can be a a safe and effective agent in the complex treatment of menopausal women with metabolic syndrome.

The aim of the study is to determine the prospects of using the epiphysis hormone melatonin in the complex treatment of menopausal metabolic syndrome based on the analysis of scientific publications.

Material and methods The review includes data from studies on the effect of melatonin (MT) on the components of metabolic syndrome in periand postmenopausal women. Sources were searched for the period 2016–2023 in the international databases Medline, Scopus, Web of Science and the Russian scientific electronic library eLibrary by search words and phrases: melatonin, menopause, perimenopause, metabolic syndrome, obesity, insulin resistance, dyslipidemia, arterial hypertension.

Results and Discussion The analysis of the literature data showed a number of advantages of the effect of exogenous MT preparations on individual components of metabolic syndrome, but some results were contradictory. Scientific evidence of MT influence on anthropometric indices, markers of glucose homeostasis, hemodynamic parameters and signs of body's inflammatory response, as well as multidirectional effects on lipid profile was found.

Conclusion Given the multifunctionality and safety of exogenous MT preparations, its use in the complex therapy of menopausal metabolic syndrome should be considered.

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The authors declare that there are no conflicts of interest present.