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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urmj</journal-id><journal-title-group><journal-title xml:lang="ru">Уральский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Ural Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-4389</issn><publisher><publisher-name>Ural State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52420/umj.23.3.79</article-id><article-id custom-type="edn" pub-id-type="custom">VULGFW</article-id><article-id custom-type="elpub" pub-id-type="custom">urmj-1537</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинические случаи | Clinical cases</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical cases</subject></subj-group></article-categories><title-group><article-title>Трудности дифференциальной диагностики язвенной болезни и злокачественных новообразований желудка</article-title><trans-title-group xml:lang="en"><trans-title>Difficulties of Differential Diagnosis of Peptic Ulcer and Stomach Cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6176-4026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Александровна Степина — кандидат медицинских наук, доцент кафедры госпитальной терапии и кардиологии</p><p>Пермь</p></bio><bio xml:lang="en"><p>Ekaterina A. Stepina — Candidate of Sciences (Medicine), Associate Professor of the Department of Hospital Therapy and Cardiology</p><p>Perm</p></bio><email xlink:type="simple">kati.aleksa@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчинникова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovchinnikova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Викторовна Овчинникова — студент лечебного факультета</p><p>Пермь</p></bio><bio xml:lang="en"><p>Natalja V. Ovchinnikova  — Specialist’s Degree Student of the Faculty of General Medicine</p><p>Perm</p></bio><email xlink:type="simple">natashaovchinnikova01@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Четина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chetina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Александровна Четина — студент лечебного факультета</p><p>Пермь</p></bio><bio xml:lang="en"><p>Anastasia A. Chetina — Specialist’s  Degree  Student  of  the  Faculty  of  General  Medicine</p><p>Perm</p></bio><email xlink:type="simple">levushkach@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4860-0112</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хлынова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khlynova</surname><given-names>О. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Витальевна Хлынова — доктор медицинских наук, профессор, член-корреспондент Российской академии наук, заведующий кафедрой госпитальной терапии и кардиологии</p><p>Пермь</p></bio><bio xml:lang="en"><p>Olga V. Khlynova — Doctor of Sciences (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Hospital Therapy and Cardiology</p><p>Perm</p></bio><email xlink:type="simple">olgakhlynova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пермский государственный медицинский университет имени академика Е. А. Вагнера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician E. A. Wagner Perm State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>12</day><month>07</month><year>2024</year></pub-date><volume>23</volume><issue>3</issue><fpage>79</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степина Е.А., Овчинникова Н.В., Четина А.А., Хлынова О.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Степина Е.А., Овчинникова Н.В., Четина А.А., Хлынова О.В.</copyright-holder><copyright-holder xml:lang="en">Stepina E.A., Ovchinnikova N.V., Chetina A.A., Khlynova О.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.umjusmu.ru/jour/article/view/1537">https://www.umjusmu.ru/jour/article/view/1537</self-uri><abstract><sec><title>Введение</title><p>Введение. Рак желудка представляет собой серьезную проблему современной медицины и является одним из самых распространенных злокачественных заболеваний в мире, находясь на четвертом месте среди причин смертности от онкологических заболеваний. Большинство пациентов обращается за медицинской помощью на поздних стадиях заболевания, как следствие, летальность в течение первого года после установления диагноза составляет около 50 %.</p></sec><sec><title>Описание</title><p>Описание. Представлен случай клинического наблюдения пациента с диагностированной перстневидноклеточной карциномой желудка. В ходе описания выделены ключевые аспекты, требующие внимания при определении факторов риска, тактики обследования и ведения пациента с подозрением на злокачественное заболевание желудка.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Клиницисту важно помнить, что инфильтративно-язвенные формы рака характеризуются стертой клинической картиной и нередко замаскированы под сопутствующей патологией. Дополнительную сложность представляет проведение дифференциальной диагностики инфильтративной формы рака желудка и язвенной болезни. Только комплексное обследование, включающее в себя клинические, лабораторные, инструментальные исследования, в т. ч. проведение морфологической оценки биоптатов из краев язвы, имеет решающее значение в своевременном установлении диагноза злокачественного заболевания желудка.</p></sec><sec><title>Выводы</title><p>Выводы. Обнаружение заболевания на начальных стадиях позволяет не только значительно повысить шансы пациента на полное излечение, но и проводить терапию с помощью максимально щадящих методов. Проведение дифференциальной диагностики между язвенной болезнью и инфильтративным раком желудка представляет особую сложность. Только комплексное клиническое, лабораторное и инструментальное обследования пациентов способствует раннему установлению верного диагноза и, как следствие, своевременному проведенному хирургическому лечению.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Stomach cancer is a serious problem of modern medicine and is one of the most common malignant diseases in the world, being in fourth place among the causes of death from cancer. Most patients seek medical help in the late stages of the disease and, as a result, mortality during the first year after diagnosis is about 50 %.</p></sec><sec><title>Description</title><p>Description. A case of clinical observation of a patient with diagnosed ring-cell carcinoma of the stomach is presented. In the course of the description, key aspects that require attention in determining risk factors, examination tactics and management of a patient with suspected malignant gastric disease are highlighted.</p></sec><sec><title>Conclusions</title><p>Conclusions. Detection of the disease in the early stages allows not only to significantly increase the patient’s chances of a complete cure, but also to carry out therapy using the most gentle methods. The differential diagnosis of peptic ulcer disease and infiltrative gastric cancer is particularly difficult. Comprehensive clinical, laboratory and instrumental examination of patients contributes to the early establishment of a correct diagnosis and, as a result, timely surgical treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>язвенная болезнь</kwd><kwd>перстневидноклеточная карцинома</kwd><kwd>факторы риска</kwd><kwd>дифференциальная диагностика</kwd><kwd>тактика ведения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>peptic ulcer disease</kwd><kwd>ring-cell carcinoma</kwd><kwd>risk factors</kwd><kwd>differential diagnosis</kwd><kwd>management tactics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA: A Cancer Journal for Clinicians. 2021;71(1):7–33. DOI: https://doi.org/10.3322/caac.21654. Erratum in: CA: A Cancer Journal for Clinicians. 2021;71(4):359. 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