urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.23.3.163MTGAGOurmj-1544Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsВлияние тиреоидного статуса на особенности течения перименопаузыThe Effect of Thyroid Status on the Features of the Course of Perimenopausehttps://orcid.org/0009-0003-5480-1567ДубровинаЕ. А.DubrovinaE. A.

Елизавета Алексеевна Дубровина — ординатор кафедры акушерства и гинекологии

Оренбург

Elizaveta A. Dubrovina — Resident of the Department of Obstetrics and Gynecology

Orenburg

liza5567@yandex.ruhttps://orcid.org/0000-0003-0023-2533КшнясеваС. К.KshnyasevaS. K.

Светлана Константиновна Кшнясева — доктор медицинских наук, доцент кафедры акушерства и гинекологии, Оренбургский государственный медицинский университет, Оренбург, Россия; заведующий женской консультацией № 4, Оренбургский клинический перинатальный центр

Оренбург

Svetlana K. Kshnyaseva — Doctor of Sciences (Medicine), Associate Professor of the Department of Obstetrics and Gynecology, Orenburg State Medical University, Orenburg, Russia; Head of the Women’s Clinic No. 4

Orenburg

hypoxya@mail.ruhttps://orcid.org/0000-0003-0369-0281КонстантиноваО. Д.KonstantinovaO. D.

Ольга Дмитриевна Константинова — доктор медицинских наук, профессор, заведующий кафедрой акушерства и гинекологии

Оренбург

Olga D. Konstantinova — Doctor of Sciences (Medicine), Professor, Head of the Department of Obstetrics and Gynecology

Orenburg

const55@mail.ruhttps://orcid.org/0009-0006-3014-5966ДубровинаГ. В.DubrovinaG. V.

Галина Владимировна Дубровина — кандидат медицинских наук, заведующий стационаром дневного пребывания № 1

Оренбург

Galina V. Dubrovina — Candidate of Sciences (Medicine), Head of the Day Care Hospital No. 1

Orenburg

dubrovinagalina10@yandex.ruОренбургский государственный медицинский университетРоссияOrenburg State Medical UniversityRussian FederationОренбургский государственный медицинский университет; Оренбургский клинический перинатальный центрРоссияOrenburg State Medical University; Orenburg Clinical Perinatal CenterRussian FederationОренбургский клинический перинатальный центрРоссияOrenburg Clinical Perinatal CenterRussian Federation202412072024233163178Copyright © Дубровина Е.А., Кшнясева С.К., Константинова О.Д., Дубровина Г.В., 20242024Дубровина Е.А., Кшнясева С.К., Константинова О.Д., Дубровина Г.В.Dubrovina E.A., Kshnyaseva S.K., Konstantinova O.D., Dubrovina G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1544Введение

Введение. По статистике средняя продолжительность жизни женской популяции неуклонно растет и более ⅓ своей жизни женщина находится в перии постменопаузе. Перименопауза включает в себя период менопаузального перехода и 12 месяцев после последней самостоятельной менструации. Многие женщины подходят к периоду перименопаузы с имеющимися заболеваниями эндокринной системы, чаще всего связанными с щитовидной железой. Такая высокая распространенность этой патологии возникает вследствие природного дефицита йода практически на всей территории России. По этой причине взаимосвязь симптомов менопаузы и эндокринных заболеваний очень актуальна.

Цель работы — провести анализ данных, представленных в современной литературе, о влиянии тиреоидного статуса на особенности течения перименопаузы.

Материалы и методы

Материалы и методы. Обзор основан на данных отечественных и зарубежных исследований, полученных в результате выборочного поиска в электронных базах PubMed и eLibrary с 2016 по 2023 г.

Результаты и обсуждение

Результаты и обсуждение. Период перименопаузы сопровождается повышением частоты встречаемости заболеваний щитовидной железы. Проведенный анализ литературных данных показал наличие влияния тиреоидного статуса на особенности течения перименопаузы и состояния, сопровождающие ее (нарушение когнитивных функций, изменение метаболизма костной ткани, частота аномальных маточных кровотечений, риск сердечно-сосудистых заболеваний).

Заключение

Заключение. Учитывая взаимосвязь тиреоидного статуса с особенностями течения перименопаузы, необходимо рассмотреть возможность комплексной терапии заболеваний щитовидной железы и коррекции симптомов климактерического синдрома.

Introduction

Introduction. According to statistics, the average life expectancy of the female population is steadily increasing and more than ⅓ of a woman’s life is in the period of periand postmenopause. Many women approach the period of perimenopause with existing diseases of the endocrine system, most often associated with the thyroid gland. Such a high prevalence of this pathology occurs due to natural iodine deficiency in almost the entire territory of the Russia. Therefore, the relationship between the symptoms of menopause and endocrine diseases is very relevant.

The purpose of the work is to analyze the data presented in the modern literature on the influence of thyroid status on the features of the course of perimenopause.

Materials and methods

Materials and methods. This review is based on data from domestic and foreign studies obtained as a result of a selective search in the electronic databases PubMed and eLibrary from 2016 to 2023.

Results and discussion

Results and discussion. The period of perimenopause is accompanied by an increase in the incidence of thyroid diseases. The analysis of the literature data showed the influence of thyroid status on the features of the course of perimenopause and the conditions accompanying it (impaired cognitive functions, changes in bone metabolism, the frequency of abnormal uterine bleeding, the risk of cardiovascular diseases).

Conclusion

Conclusion. Given the relationship of thyroid status with the peculiarities of the course of perimenopause, it is necessary to consider the possibility of complex therapy of thyroid diseases and correction of symptoms of menopausal syndrome.

перименопаузаранняя постменопаузыклимактерический синдромгипотиреозгипертиреозperimenopauseearly postmenopausemenopausal syndromehypothyroidismhyperthyroidismReferencesChuchalina LU, Armashevskaya OV. Features of the health status of mature women. Modern Problems of Science and Education. 2017;(1). (In Russ.). EDN: https://elibrary.ru/xxnchl.Chuchalina LU, Armashevskaya OV. Features of the health status of mature women. Modern Problems of Science and Education. 2017;(1). (In Russ.). EDN: https://elibrary.ru/xxnchl.Artemyuk NV, Tachkova OA, Marochko TY. Modern approaches to the management of menopause. Gynecology. 2021;23(2):137–143. (In Russ.). DOI: https://doi.org/10.26442/20795696.2021.2.200691.Artemyuk NV, Tachkova OA, Marochko TY. Modern approaches to the management of menopause. Gynecology. 2021;23(2):137–143. (In Russ.). DOI: https://doi.org/10.26442/20795696.2021.2.200691.Kshnyaseva SK, Konstantinova OT, Tinkov AN. The method of hypobaric hypoxytherapy in the treatment of menopausal syndrome. Bulletin of New Medical Technologies. 2011;XVIII(2):295–297. (In Russ.). Available from: https://clck.ru/3B55s6 [accessed 20 February 2024].Kshnyaseva SK, Konstantinova OT, Tinkov AN. The method of hypobaric hypoxytherapy in the treatment of menopausal syndrome. Bulletin of New Medical Technologies. 2011;XVIII(2):295–297. (In Russ.). Available from: https://clck.ru/3B55s6 [accessed 20 February 2024].Volotskaya NI, Sulima AN, Rumyantseva Z. Menopause: Modern standards for the diagnosis and correction of disorders. Vrach. 2021;32(3):66–72. (In Russ.). DOI: https://doi.org/10.29296/25877305-2021-03-12.Volotskaya NI, Sulima AN, Rumyantseva Z. Menopause: Modern standards for the diagnosis and correction of disorders. Vrach. 2021;32(3):66–72. (In Russ.). DOI: https://doi.org/10.29296/25877305-2021-03-12.Yakushevskaya OV. Alternative correction of menopausal disorders. Medical Council. 2019;(13):131–136. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2019-13-131-136.Yakushevskaya OV. Alternative correction of menopausal disorders. Medical Council. 2019;(13):131–136. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2019-13-131-136.Berikhanov RR, Minenko IA. The functional state of the thyroid gland in patients with metabolic syndrome in menopause: The effect of non-drug therapy. In: Innovation, technology, science. Ufa: Omega Science; 2016. 148–149 p. (In Russ.). EDN: https://elibrary.ru/wiwtpx.Berikhanov RR, Minenko IA. The functional state of the thyroid gland in patients with metabolic syndrome in menopause: The effect of non-drug therapy. In: Innovation, technology, science. Ufa: Omega Science; 2016. 148–149 p. (In Russ.). EDN: https://elibrary.ru/wiwtpx.Zaidieva YAZ. Alternative therapy for menopausal disorders in menopausal women. Russian Medical Journal. 2017;(12):873–878. (In Russ.). EDN: https://elibrary.ru/zmynfp.Zaidieva YAZ. Alternative therapy for menopausal disorders in menopausal women. Russian Medical Journal. 2017;(12):873–878. (In Russ.). EDN: https://elibrary.ru/zmynfp.Lambrinoudaki I, Armeni E, Goulis D, Bretz S, Ceausu I, Durmusoglu F, et al. Menopause, wellbeing and health: A care pathway from the European Menopause and Andropause Society. Maturitas. 2022;163:1–14. DOI: https://doi.org/10.1016/j.maturitas.2022.04.008.Lambrinoudaki I, Armeni E, Goulis D, Bretz S, Ceausu I, Durmusoglu F, et al. Menopause, wellbeing and health: A care pathway from the European Menopause and Andropause Society. Maturitas. 2022;163:1–14. DOI: https://doi.org/10.1016/j.maturitas.2022.04.008.Tsvetkova TP. New approaches to the diagnosis and treatment of early symptoms of pathological manifestations of menopausal syndrome. Sciences of Europe. 2017;(12–2):119–121. (In Russ.). EDN: https://elibrary.ru/ygivtv.Tsvetkova TP. New approaches to the diagnosis and treatment of early symptoms of pathological manifestations of menopausal syndrome. Sciences of Europe. 2017;(12–2):119–121. (In Russ.). EDN: https://elibrary.ru/ygivtv.Berikhanova RR, Minenko IA. Complex non-drug correction of climacteric disorders in women with metabolic syndrome: Influence on the intestinal microbiocenosis. In: Biological features of medicinal and aromatic plants and their role in medicine. Moscow: Shcherbinskaya Printing House; 2016. P. 567–569. (In Russ.). EDN: https://elibrary.ru/wegxbd.Berikhanova RR, Minenko IA. Complex non-drug correction of climacteric disorders in women with metabolic syndrome: Influence on the intestinal microbiocenosis. In: Biological features of medicinal and aromatic plants and their role in medicine. Moscow: Shcherbinskaya Printing House; 2016. P. 567–569. (In Russ.). EDN: https://elibrary.ru/wegxbd.Madyanov IV, Madyanovа TS. Menopausal hormonal therapy in major endocrine diseases. Practical Medicine. 2019;17(4):118–122. DOI: https://doi.org/10.32000/2072-1757-2019-4-118-122.Madyanov IV, Madyanovа TS. Menopausal hormonal therapy in major endocrine diseases. Practical Medicine. 2019;17(4):118–122. DOI: https://doi.org/10.32000/2072-1757-2019-4-118-122.Miroshnikov SV, Notova SV, Kvan OV, Timasheva AB. Features of the elemental composition of nodular euthyroid formations of the thyroid gland and perinodular thyroid tissue in women with abnormal TSH levels. Trace Elements in Medicine. 2013;14(3):40–44. (In Russ.). EDN: https://elibrary.ru/rsiwjz.Miroshnikov SV, Notova SV, Kvan OV, Timasheva AB. Features of the elemental composition of nodular euthyroid formations of the thyroid gland and perinodular thyroid tissue in women with abnormal TSH levels. Trace Elements in Medicine. 2013;14(3):40–44. (In Russ.). EDN: https://elibrary.ru/rsiwjz.Dydyshko UV. The content of micronutrients (folates, iodine) and a woman’s health in the post-reproductive period. Medical News. 2022;(2):63–71. (In Russ). EDN: https://elibrary.ru/bfjeec.Dydyshko UV. The content of micronutrients (folates, iodine) and a woman’s health in the post-reproductive period. Medical News. 2022;(2):63–71. (In Russ). EDN: https://elibrary.ru/bfjeec.Kravtsova ON, Sagitova ER, Averyanov VN. The current state of morbidity of the adult population with thyroid pathology caused by iodine deficiency. Orenburg Medical Bulletin. 2021;9(2):56–60. (In Russ.). EDN: https://elibrary.ru/zpobby.Kravtsova ON, Sagitova ER, Averyanov VN. The current state of morbidity of the adult population with thyroid pathology caused by iodine deficiency. Orenburg Medical Bulletin. 2021;9(2):56–60. (In Russ.). EDN: https://elibrary.ru/zpobby.Melnichenko GA, Troshina EA, Platonova NM, Panfilova EA, Rybakova AA, Abdulkhabirova FM, et al. Iodine deficiency thyroid disease in the Russian Federation: The current state of the problem. Аnalytical review of publications and data of official state statistics (Rosstat). Consilium Medicum. 2019;21(4):14–20. (In Russ.). Available from: https://clck.ru/3B69JL [accessed 10 February 2024].Melnichenko GA, Troshina EA, Platonova NM, Panfilova EA, Rybakova AA, Abdulkhabirova FM, et al. Iodine deficiency thyroid disease in the Russian Federation: The current state of the problem. Аnalytical review of publications and data of official state statistics (Rosstat). Consilium Medicum. 2019;21(4):14–20. (In Russ.). Available from: https://clck.ru/3B69JL [accessed 10 February 2024].Zaidieva YaZ, Glazkova AV, Kruchinina EV. Thyroid disease in peri- and postmenopause period (literature review). Medical alphabet. 2019;4(33):48–53. (In Russ.). DOI: https://doi.org/10.33667/2078–5631-2019-4-33(408)-48-53.Zaidieva YaZ, Glazkova AV, Kruchinina EV. Thyroid disease in peri- and postmenopause period (literature review). Medical alphabet. 2019;4(33):48–53. (In Russ.). DOI: https://doi.org/10.33667/2078–5631-2019-4-33(408)-48-53.Sokolova MU, Varlamova TM. Menopausal syndrome and hypofunction of the thyroid gland. Gynecology. 2005;7(3):145–146. (In Russ.). Available from: https://clck.ru/3B6BmQ [accessed 20 February 2024].Sokolova MU, Varlamova TM. Menopausal syndrome and hypofunction of the thyroid gland. Gynecology. 2005;7(3):145–146. (In Russ.). Available from: https://clck.ru/3B6BmQ [accessed 20 February 2024].Kobernik MU, Sandakova EA, Elkin VD. Pathological menopause and hypothyroidism as factors of menopausal skin aging. Practical Medicine. 2013;(7):140–143. (In Russ.). EDN: https://elibrary.ru/sallop.Kobernik MU, Sandakova EA, Elkin VD. Pathological menopause and hypothyroidism as factors of menopausal skin aging. Practical Medicine. 2013;(7):140–143. (In Russ.). EDN: https://elibrary.ru/sallop.Adamyan LV, Sibirskaya YeV, Pivazyan LG, Zakaryan AA, Nosenko KM, Obosyan LB. The link between thyroid diseases and the reproductive system of women and adolescent girls: Literature review. Effective Pharmacotherapy. 2023;19(23):34–37. (In Russ.). EDN: https://elibrary.ru/ekledc.Adamyan LV, Sibirskaya YeV, Pivazyan LG, Zakaryan AA, Nosenko KM, Obosyan LB. The link between thyroid diseases and the reproductive system of women and adolescent girls: Literature review. Effective Pharmacotherapy. 2023;19(23):34–37. (In Russ.). EDN: https://elibrary.ru/ekledc.Rzakulieva LM, Hajizade AE. Features of the reproductive system in women with infertility in hyperthyroidism. Perm Medical Journal. 2021;38(1):64–71. (In Russ). DOI: https://doi.org/10.17816/pmj38164-71.Rzakulieva LM, Hajizade AE. Features of the reproductive system in women with infertility in hyperthyroidism. Perm Medical Journal. 2021;38(1):64–71. (In Russ). DOI: https://doi.org/10.17816/pmj38164-71.Baber RJ, Panay N, Fenton A; IMS Writing Group NS. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016;19(2):109–150. DOI: https://doi.org/10.3109/13697137.2015.1129166.Baber RJ, Panay N, Fenton A; IMS Writing Group NS. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016;19(2):109–150. DOI: https://doi.org/10.3109/13697137.2015.1129166.Schindler AE. Thyroid function and post menopause. Gynecological Endocrinology. 2003;17(1):79–85. DOI: https://doi.org/10.1080/gye.17.1.79.85.Schindler AE. Thyroid function and post menopause. Gynecological Endocrinology. 2003;17(1):79–85. DOI: https://doi.org/10.1080/gye.17.1.79.85.Uygur MM, Yoldemir T, Yavuz DG. Thyroid disease in the perimenopause and postmenopause period. Climacteric. 2018;21(6):542–548. (In Russ.). DOI: https://doi.org/10.1080/13697137.2018.1514004.Uygur MM, Yoldemir T, Yavuz DG. Thyroid disease in the perimenopause and postmenopause period. Climacteric. 2018;21(6):542–548. (In Russ.). DOI: https://doi.org/10.1080/13697137.2018.1514004.Capozzi А, Scambia G, Lello S. Subclinical hypothyroidism in women’s health: From pre- to post-menopause. Gynecological Endocrinology. 2022;38(5):357–367. DOI: https://doi.org/10.1080/09513590.2022.2046728.Capozzi А, Scambia G, Lello S. Subclinical hypothyroidism in women’s health: From pre- to post-menopause. Gynecological Endocrinology. 2022;38(5):357–367. DOI: https://doi.org/10.1080/09513590.2022.2046728.del Ghianda S, Tonacchera M, Vitti P. Thyroid and menopause. Climacteric. 2014;17(3):225–234. DOI: https://doi.org/10.3109/13697137.2013.838554.del Ghianda S, Tonacchera M, Vitti P. Thyroid and menopause. Climacteric. 2014;17(3):225–234. DOI: https://doi.org/10.3109/13697137.2013.838554.Tremollieres F, Brincat M, Erel CT, Gambacciani M, Lambrinoudaki I, Moen MH, et al. EMAS position statement: Managing menopausal women with a personal or family history of VTE. Maturitas. 2011;69(2): 195–198. (In Russ.). DOI: https://doi.org/10.1016/j.maturitas.2011.03.011.Tremollieres F, Brincat M, Erel CT, Gambacciani M, Lambrinoudaki I, Moen MH, et al. EMAS position statement: Managing menopausal women with a personal or family history of VTE. Maturitas. 2011;69(2): 195–198. (In Russ.). DOI: https://doi.org/10.1016/j.maturitas.2011.03.011.Yureneva SV, Ermakova EI. Evaluation of the effectiveness of alternative treatments for menopausal symptoms in postmenopausal women. Medical Council. 2017;(2):76–80. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2017-2-76-80.Yureneva SV, Ermakova EI. Evaluation of the effectiveness of alternative treatments for menopausal symptoms in postmenopausal women. Medical Council. 2017;(2):76–80. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2017-2-76-80.Pizova NV, Pizov NA, Pizov AV. Perimenopausal period and mood disorders. Medical Council. 2021;(4): 230–239. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2021-4-230-239.Pizova NV, Pizov NA, Pizov AV. Perimenopausal period and mood disorders. Medical Council. 2021;(4): 230–239. (In Russ.). DOI: https://doi.org/10.21518/2079-701X-2021-4-230-239.Goyal G, Goyal LD, Singla H, Sheenam, Arora K, Kaur H. Subclinical hypothyroidism and associated cardiovascular risk factor in perimenopausal females. Journal of Mid-life Health. 2020;11(1):6–11. (In Russ.). DOI: https://doi.org/10.4103/jmh.JMH_38_19.Goyal G, Goyal LD, Singla H, Sheenam, Arora K, Kaur H. Subclinical hypothyroidism and associated cardiovascular risk factor in perimenopausal females. Journal of Mid-life Health. 2020;11(1):6–11. (In Russ.). DOI: https://doi.org/10.4103/jmh.JMH_38_19.Esedova TM, Esedova AE, Nasrullaeva NKh, Gadzhieva MM, Gurova LV, Ferzilaeva RA. Parameters of lipid metabolism during perimenopause and thyroid pathology. Klinicheskaya Laboratornaya Diagnostika. 2000;(6):10–13. (In Russ.). PMID: https://pubmed.ncbi.nlm.nih.gov/10900853.Esedova TM, Esedova AE, Nasrullaeva NKh, Gadzhieva MM, Gurova LV, Ferzilaeva RA. Parameters of lipid metabolism during perimenopause and thyroid pathology. Klinicheskaya Laboratornaya Diagnostika. 2000;(6):10–13. (In Russ.). PMID: https://pubmed.ncbi.nlm.nih.gov/10900853.Müller P, Leow MK, Dietrich JW. Minor perturbations of thyroid homeostasis and major cardiovascular endpoints — Physiological mechanisms and clinical evidence. Frontiers in Cardiovascular Medicine. 2022;9(8):942971. DOI: https://doi.org/10.3389/fcvm.2022.942971.Müller P, Leow MK, Dietrich JW. Minor perturbations of thyroid homeostasis and major cardiovascular endpoints — Physiological mechanisms and clinical evidence. Frontiers in Cardiovascular Medicine. 2022;9(8):942971. DOI: https://doi.org/10.3389/fcvm.2022.942971.Gerasimenko NF, Oganov RG, Mychka VB. A woman’s heart. Cardiovascular Therapy and Prevention. 2011;10(1):5–8. (In Russ.). EDN: https://elibrary.ru/mjqelz.Gerasimenko NF, Oganov RG, Mychka VB. A woman’s heart. Cardiovascular Therapy and Prevention. 2011;10(1):5–8. (In Russ.). EDN: https://elibrary.ru/mjqelz.Frank-Raue K, Raue F. Thyroid dysfunction in periand postmenopausal women-cumulative risks. Deutsches Ärzteblatt International. 2023;120(18):311–316. DOI: https://doi.org/10.3238/arztebl.m2023.0069.Frank-Raue K, Raue F. Thyroid dysfunction in periand postmenopausal women-cumulative risks. Deutsches Ärzteblatt International. 2023;120(18):311–316. DOI: https://doi.org/10.3238/arztebl.m2023.0069.Sahu HD, Varma AV, Karmarkar S, Malukani K, Khanuja A, Kesharwani P. Endometrial histopathology in abnormal uterine bleeding and its relation with thyroid profile and endometrial thickness. Cureus. 2023;15(4):е37931. DOI: https://doi.org/10.7759/cureus.37931.Sahu HD, Varma AV, Karmarkar S, Malukani K, Khanuja A, Kesharwani P. Endometrial histopathology in abnormal uterine bleeding and its relation with thyroid profile and endometrial thickness. Cureus. 2023;15(4):е37931. DOI: https://doi.org/10.7759/cureus.37931.Subbotina KV. Effectiveness of treatment of recurrent endometrial hyperplastic processes in women of reproductive age during perimenopause. Abstracts III The All-Russian scientific and practical conference for obstetricians and gynecologists “Otto Readings”. Moscow: StatusPraesens; 2021. P. 70–71. (In Russ.). EDN: https://elibrary.ru/ptmclq.Subbotina KV. Effectiveness of treatment of recurrent endometrial hyperplastic processes in women of reproductive age during perimenopause. Abstracts III The All-Russian scientific and practical conference for obstetricians and gynecologists “Otto Readings”. Moscow: StatusPraesens; 2021. P. 70–71. (In Russ.). EDN: https://elibrary.ru/ptmclq.Byna P, Siddula S, Kolli S, Shaik MV. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding. International Journal of Research in Medical Sciences. 2015;3(11):3250–3253. DOI: https://doi.org/10.18203/2320-6012.ijrms20151171.Byna P, Siddula S, Kolli S, Shaik MV. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding. International Journal of Research in Medical Sciences. 2015;3(11):3250–3253. DOI: https://doi.org/10.18203/2320-6012.ijrms20151171.Askarova Z. The frequency of somatic diseases in women with hyperplastic diseases of the uterus and mammary glands during perimenopause. Eurasian Journal of Medical and Natural Sciences. 2023;3(2):180–185. (In Russ.). Available from: https://clck.ru/3B6Hi5 [accessed 25 February 2024].Askarova Z. The frequency of somatic diseases in women with hyperplastic diseases of the uterus and mammary glands during perimenopause. Eurasian Journal of Medical and Natural Sciences. 2023;3(2):180–185. (In Russ.). Available from: https://clck.ru/3B6Hi5 [accessed 25 February 2024].Yadav M, Kose V, Bhalerao A. Frequency of thyroid disorder in pre- and postmenopausal women and its association with menopausal symptoms. Cureus. 2023;15(6):e40900. DOI: https://doi.org/10.7759/cureus.40900.Yadav M, Kose V, Bhalerao A. Frequency of thyroid disorder in pre- and postmenopausal women and its association with menopausal symptoms. Cureus. 2023;15(6):e40900. DOI: https://doi.org/10.7759/cureus.40900.Shaikh S, Fawad N, Sajjad A, Sadia S. Hypothyroidism screening in menopausal women. Pak J Med Health Sci. 2017;11(1):14–17. Available from: https://clck.ru/3B6Kdo [accessed 1 February 2024].Shaikh S, Fawad N, Sajjad A, Sadia S. Hypothyroidism screening in menopausal women. Pak J Med Health Sci. 2017;11(1):14–17. Available from: https://clck.ru/3B6Kdo [accessed 1 February 2024].Gromova VA, Vorokhobina NV, Malygina OF, Kuznetsova AV. Efficiency of the low-dose forms estrogen-gestagen drug treatmentto women with compensated hypotheriosis and euthyroidism. Herald of North-Western State Medical University named after I.I. Mechnikov. 2015;7(1):40–45. (In Russ.). DOI: https://doi.org/10.17816/mechnikov20157140-45.Gromova VA, Vorokhobina NV, Malygina OF, Kuznetsova AV. Efficiency of the low-dose forms estrogen-gestagen drug treatmentto women with compensated hypotheriosis and euthyroidism. Herald of North-Western State Medical University named after I.I. Mechnikov. 2015;7(1):40–45. (In Russ.). DOI: https://doi.org/10.17816/mechnikov20157140-45.Uehara M, Wada-Hiraike O, Hirano M, Koga K, Yoshimura N, Tanaka S, et al. Relationship between bone mineral density and ovarian function and thyroid function in perimenopausal women with endometriosis: A prospective study. BMC Women’s Health. 2022;22(1):134. DOI: https://doi.org/10.1186/s12905-022-01711-3.Uehara M, Wada-Hiraike O, Hirano M, Koga K, Yoshimura N, Tanaka S, et al. Relationship between bone mineral density and ovarian function and thyroid function in perimenopausal women with endometriosis: A prospective study. BMC Women’s Health. 2022;22(1):134. DOI: https://doi.org/10.1186/s12905-022-01711-3.Sebtain A, Qasim M, Bahadur A, Ali A, Samin KA, Ahmed M. Subclinical hypothyroidism in perimenopausal abnormal uterine bleeding patients. Cureus, 2022;14(2):e21839. DOI: https://doi.org/10.7759/cureus.21839.Sebtain A, Qasim M, Bahadur A, Ali A, Samin KA, Ahmed M. Subclinical hypothyroidism in perimenopausal abnormal uterine bleeding patients. Cureus, 2022;14(2):e21839. DOI: https://doi.org/10.7759/cureus.21839.Slopien R, Owecki M, Slopien A, Bala G, Meczekalski B. Climacteric symptoms are related to thyroid status in euthyroid menopausal women. Journal of Endocrinological Investigation. 2020;43(1):75–80. DOI: https://doi.org/10.1007/s40618-019-01078-7.Slopien R, Owecki M, Slopien A, Bala G, Meczekalski B. Climacteric symptoms are related to thyroid status in euthyroid menopausal women. Journal of Endocrinological Investigation. 2020;43(1):75–80. DOI: https://doi.org/10.1007/s40618-019-01078-7.Kim Y, Chang Y, Cho IY, Kwon R, Lim GY, Jee JH, et al. The prevalence of thyroid dysfunction in Korean women undergoing routine health screening: A cross-sectional study. Thyroid. 2022;32(7):819–827. DOI: https://doi.org/10.1089/thy.2021.0544.Kim Y, Chang Y, Cho IY, Kwon R, Lim GY, Jee JH, et al. The prevalence of thyroid dysfunction in Korean women undergoing routine health screening: A cross-sectional study. Thyroid. 2022;32(7):819–827. DOI: https://doi.org/10.1089/thy.2021.0544.Van Rijn LE, Pop VJ, Williams GR. Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women. European Journal of Endocrinology. 2014;170(3):461–468. DOI: https://doi.org/10.1530/EJE-13-0769.Van Rijn LE, Pop VJ, Williams GR. Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women. European Journal of Endocrinology. 2014;170(3):461–468. DOI: https://doi.org/10.1530/EJE-13-0769.Usha SMR, Bindu CM, Chandrika N. Thyroid dysfunction: An alternate plausibility in perimenopausal women. Journal of Mid-life Health. 2022;13(4):300–303. DOI: https://doi.org/10.4103/jmh.jmh_67_22.Usha SMR, Bindu CM, Chandrika N. Thyroid dysfunction: An alternate plausibility in perimenopausal women. Journal of Mid-life Health. 2022;13(4):300–303. DOI: https://doi.org/10.4103/jmh.jmh_67_22.Panda S, Das A. Analyzing thyroid dysfunction in the climacteric. Journal of Mid-life Health. 2018;9(3): 113–116. DOI: https://doi.org/10.4103/jmh.JMH_21_18.Panda S, Das A. Analyzing thyroid dysfunction in the climacteric. Journal of Mid-life Health. 2018;9(3): 113–116. DOI: https://doi.org/10.4103/jmh.JMH_21_18.Chandrashekhar GS. Comparison of thyroid profile in premenopausal and postmenopausal women: A case control study. International Journal of Medical Research & Review. 2018;6(7):367–371. DOI: https://doi.org/10.17511/ijmrr.2018.i07.05.Chandrashekhar GS. Comparison of thyroid profile in premenopausal and postmenopausal women: A case control study. International Journal of Medical Research & Review. 2018;6(7):367–371. DOI: https://doi.org/10.17511/ijmrr.2018.i07.05.Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133. DOI: https://doi.org/10.1089/thy.2015.0020.Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133. DOI: https://doi.org/10.1089/thy.2015.0020.Dhaker D, Deshmukh A. Thyroid profile in perimenopausal women: A study to rule out hypothyroidism in the subclinical stage and its relationship to cholesterol levels. National Journal of Physiology, Pharmacy and Pharmacology. 2022;12(3):371–374. DOI: https://doi.org/10.5455/njppp.2022.12.02062202111022022.Dhaker D, Deshmukh A. Thyroid profile in perimenopausal women: A study to rule out hypothyroidism in the subclinical stage and its relationship to cholesterol levels. National Journal of Physiology, Pharmacy and Pharmacology. 2022;12(3):371–374. DOI: https://doi.org/10.5455/njppp.2022.12.02062202111022022.Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. The Journal of Clinical Endocrinology & Metabolism. 2010;95(1):186–193. DOI: https://doi.org/10.1210/jc.2009-1625.Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. The Journal of Clinical Endocrinology & Metabolism. 2010;95(1):186–193. DOI: https://doi.org/10.1210/jc.2009-1625.Bordoloi G, Jahan W. A study of thyroid function in premenopausal and postmenopausal women of Dibrugarh town, Assam, India. International Journal of Research in Medical Sciences. 2018;6(9):3015–3019. DOI: https://doi.org/10.18203/2320-6012.ijrms20183636.Bordoloi G, Jahan W. A study of thyroid function in premenopausal and postmenopausal women of Dibrugarh town, Assam, India. International Journal of Research in Medical Sciences. 2018;6(9):3015–3019. DOI: https://doi.org/10.18203/2320-6012.ijrms20183636.Abusuev SA, Khashaeva TX, Esedova AE. Features of perimenopause in endemic goiter in women with hypothyroidism. Problems of Endocrinology. 2000;46(1):12–16. (In Russ.). EDN: https://elibrary.ru/vkqddk.Abusuev SA, Khashaeva TX, Esedova AE. Features of perimenopause in endemic goiter in women with hypothyroidism. Problems of Endocrinology. 2000;46(1):12–16. (In Russ.). EDN: https://elibrary.ru/vkqddk.Yurasova EA, Shmatkova AS, Bogachenko AS, Tolmachev AV, Postnikov AA, Shveeva MS, et al. Premature ovarian failure. A modern view of the problem. In: New technologies in obstetrics and gynecology. Khabarovsk: Far-East State Medical University; 2021. P. 140–157. EDN: https://elibrary.ru/bmcqrw.Yurasova EA, Shmatkova AS, Bogachenko AS, Tolmachev AV, Postnikov AA, Shveeva MS, et al. Premature ovarian failure. A modern view of the problem. In: New technologies in obstetrics and gynecology. Khabarovsk: Far-East State Medical University; 2021. P. 140–157. EDN: https://elibrary.ru/bmcqrw.Dubrovina SO, Kirevnina LV. Thyroid gland in peri- and postmenopausal women: Physiology and diseases. Clinical Review for General Practice. 2021;(1):44–49. (In Russ.). DOI: https://doi.org/10.47407/kr2021.2.1.00031.Dubrovina SO, Kirevnina LV. Thyroid gland in peri- and postmenopausal women: Physiology and diseases. Clinical Review for General Practice. 2021;(1):44–49. (In Russ.). DOI: https://doi.org/10.47407/kr2021.2.1.00031.

The authors declare that there are no conflicts of interest present.