urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.23.3.179QSCYUHurmj-1545Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsВозможности прогнозирования манифестации HELLP‑синдромаPossibilities of Predicting the Manifestation of HELLP Syndromehttps://orcid.org/0000-0002-6113-8498ШифманЕ. М.ShifmanE. M.

Ефим Муневич Шифман — доктор медицинских наук, профессор кафедры анестезиологии и реаниматологии факультета усовершенствования врачей

Москва

Efim M. Shifman — Doctor of Sciences (Medicine), Professor of the Department of Anesthesiology and Intensive Care of the Faculty of Advanced Medical Education

Moscow

eshifman@mail.ruhttps://orcid.org/0000-0001-7220-0421ПылаеваН. Ю.PylaevaN. Yu.

Наталья Юрьевна Пылаева — кандидат медицинских наук, доцент кафедры общей хирургии, анестезиологии-реаниматологии и скорой медицинской помощи факультета подготовки медицинских кадров высшей квалификации и дополнительного профессионального образования Ордена Трудового Красного Знамени Медицинского института имени С. И. Георгиевского

Симферополь

Natalia Yu. Pylaeva — Candidate of Sciences (Medicine), Associate Professor of the Department of General Surgery, Anesthesiology-Resuscitation and Emergency Medicine of the Faculty of Training of Highly Qualified Personnel and Additional Professional Education of the Order of the Red Banner of Labour Medical Institute named after S. I. Georgievsky

Simferopol

natalja.pylaewa@yandex.ruhttps://orcid.org/0009-0003-6305-054XГуляевВ. В.GulyaevV. V.

Владимир Викторович Гуляев — студент стоматологического факультета Ордена Трудового Красного Знамени Медицинского института имени С. И. Георгиевского

Симферополь

Vladimir V. Gulyaev — Student of the Faculty of Dentistry of the Order of the Red Banner of Labour Medical Institute named after S. I. Georgievsky

Simferopol

gulyaevVV@mail.ruhttps://orcid.org/0000-0002-7768-4514КуликовА. В.KulikovA. V.

Александр Вениаминович Куликов — доктор медицинских наук, профессор, заведующий кафедрой анестезиологии, реаниматологии, токсикологии

Екатеринбург

Alexander V. Kulikov — Doctor of Sciences (Medicine), Professor, Head of the Department of Anesthesiology, Resuscitation, Toxicology

Ekaterinburg

kulikov1905@yandex.ruhttps://orcid.org/0000-0002-0263-3851ПылаевА. В.PylaevA. V.

Анатолий Викторович Пылаев — кандидат медицинских наук, доцент кафедры общей хирургии, анестезиологии-реаниматологии и скорой медицинской помощи факультета подготовки медицинских кадров высшей квалификации и дополнительного профессионального образования Ордена Трудового Красного Знамени Медицинского института имени С. И. Георгиевского

Симферополь

Anatoly V. Pylaev — Candidate of Sciences (Medicine), Associate Professor of the Department of General Surgery, Anesthesiology-Resuscitation and Emergency Medicine of the Faculty of Training of Highly Qualified Personnel and Additional Professional Education of the Order of the Red Banner of Labour Medical Institute named after S. I. Georgievsky

Simferopol

pylaev.an@yandex.ruhttps://orcid.org/0000-0002-1293-4201КазининаЕ. Н.KazininaE. N.

Елена Николаевна Казинина — кандидат медицинских наук, доцент кафедры стоматологии и ортодонтии факультета подготовки медицинских кадров высшей квалификации и дополнительного профессионального образования Ордена Трудового Красного Знамени Медицинского института имени С. И. Георгиевского

Симферополь

Elena N. Kazinina — Candidate of Sciences (Medicine), Associate Professor of the Department of Dentistry and Orthodontics of the Faculty of Training of Highly Qualified Personnel and Additional Professional Education of the Order of the Red Banner of Labour Medical Institute named after S. I. Georgievsky

Simferopol

kazinina@mail.ruhttps://orcid.org/0000-0003-0590-2233ПрочанЕ. Н.ProchanE. N.

Елена Николаевна Прочан — кандидат медицинских наук, доцент кафедры акушерства и гинекологии № 2 Ордена Трудового Красного Знамени Медицинского института имени С. И. Георгиевского

Симферополь

Elena N. Prochan — Candidate of Sciences (Medicine), Associate Professor of the Department of Obstetrics and Gynaecology No. 2 of the Order of the Red Banner of Labour Medical Institute named after S. I. Georgievsky

Simferopol

prochan@mail.ruМосковский областной научно-исследовательский клинический институт имени М. Ф. ВладимирскогоРоссияMoscow Regional Research Clinical InstituteRussian FederationКрымский федеральный университет имени В. И. ВернадскогоРоссияV. I. Vernadsky Crimean Federal UniversityRussian FederationУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation202412072024233179197Copyright © Шифман Е.М., Пылаева Н.Ю., Гуляев В.В., Куликов А.В., Пылаев А.В., Казинина Е.Н., Прочан Е.Н., 20242024Шифман Е.М., Пылаева Н.Ю., Гуляев В.В., Куликов А.В., Пылаев А.В., Казинина Е.Н., Прочан Е.Н.Shifman E.M., Pylaeva N.Y., Gulyaev V.V., Kulikov A.V., Pylaev A.V., Kazinina E.N., Prochan E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1545Введение

Введение. Несмотря на использование современных принципов лечения тяжелой преэклампсии, показатели летальности для матери и новорожденного при развитии такого жизнеугрожающего осложнения, как HELLP-синдром, остаются высокими. Внедрение в повседневную врачебную практику точных моделей ранней диагностики и прогнозирования вероятности манифестации и тяжести течения HELLP-синдрома позволит повысить безопасность родоразрешения беременных с тяжелой преэклампсией.

Цель исследования — определить современное состояние вопроса и систематизировать текущие данные о методах прогнозирования вероятности манифестации HELLP-синдрома.

Материалы и методы

Материалы и методы. Проведен качественный анализ клинических испытаний и обзоров, посвященных прогнозированию развития HELLP-синдрома, с использованием базы данных PubMed и поисковой системы Google Scholar. Поиск выполнялся на русском и английском языках по ключевым словам «предикторы», или «предикция», или «прогнозирование», и «HELLP-синдром». Дата последнего поискового запроса: 22 марта 2024 г.

Результаты

Результаты. Проанализированы анамнестические данные и исходные характеристики пациенток с HELLP-синдромом.

Обсуждение

Обсуждение. В аналитический обзор вошли публикации, посвященные изучению влияния предикторных возможностей потенциальных биохимических маркеров, клинико-анамнестических признаков и данных инструментального обследования на вероятность развития HELLP-синдрома.

Выводы

Выводы. Адекватное прогнозирование манифестации HELLP-синдрома возможно на основе комплексного анализа всех выявленных факторов, позволяющего определить эффективные прогностические модели в целях улучшения исходов для матери и плода у беременных с тяжелой преэклампсией.

Introduction

Introduction. Despite the use of modern principles of treatment of severe preeclampsia, mortality rates for mother and newborn in the development of life-threatening complication of preeclampsia, such as HELLP syndrome, remains high. The introduction of accurate models of early diagnosis and prediction of the probability of manifestation and severity of the HELLP syndrome into everyday medical practice will improve the safety of delivery of pregnant women with severe preeclampsia.

The aim of the study is to determine the current state of the issue and systematize current data on methods of predicting the probability of HELLP syndrome manifestation.

Materials and methods

Materials and methods. An analytical review of the literature. A qualitative analysis of clinical trials and reviews on prediction of HELLP syndrome was conducted using the following data sources: PubMed and Google Scholar. The search was carried out in Russian and English, using the keywords “predictors”, or “prediction”, and “HELLP syndrome”. The date of the last search query is 22 March 2024.

Results

Results. Anamnestic data and initial characteristics of patients with HELLP syndrome were analyzed.

Discussion

Discussion. The analytical review included publications devoted to the study of the influence of predictive capabilities of potential biochemical markers, clinical and anamnestic signs and instrumental examination data on the probability of HELLP syndrome development.

Conclusion

Conclusion. Adequate prediction of the manifestation of HELLP syndrome is possible on the basis of a comprehensive analysis of all identified factors, allowing the identification of effective prognostic models to improve maternal and fetal outcomes in pregnant women with severe preeclampsia.

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The authors declare that there are no conflicts of interest present.