Over the past decades, there has been an increase in the incidence of multiple pregnancies, which is associated with an increase in the age of parturient women, the widespread use of assisted reproductive technologies, the prolonged intake of hormonal oral contraceptives, and stimulants of ovulation. The cardiovascular system in pregnant women with multiple births undergoes major changes, which leads to a significant transformation of hemodynamic parameters. All changes in the work of the CCC of a pregnant woman are due to the formation of an additional utero-placental circle of blood circulation. Changes in the work of the cardiovascular system are associated with both hemodynamic and mechanical factors. Restructuring of the circulatory system during pregnancy consists in an increase in BCC against a background of increased capacity of the vascular bed and cardiac output, when cardiac output increases significantly. These changes provide a higher level of performance for various maternal systems, corresponding to the increasing energy and metabolic needs of the fetus.