urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.23.4.77LZNOXIurmj-1573Research ArticleОригинальные статьи | Original articlesOriginal articlesЗлокачественные новообразования молочной железы, ассоциированные с беременностьюPregnancy-Associated Breast Cancerhttps://orcid.org/0009-0000-7966-8529КиселеваК. Е.KiselyovaK. E.

Ксения Евгеньевна Киселева — онколог

Екатеринбург

Ksenia E. Kiseleva — Oncologist

Ekaterinburg

ksenkw@yandex.ruhttps://orcid.org/0000-0002-0342-4007ПеткауВ. В.PetkauV. V.

Владислав Владимирович Петкау — кандидат медицинских наук, заместитель главного врача по лекарственной терапии, доцент кафедры онкологии и лучевой диагностики

Екатеринбург

Vladislav V. Petkau — Candidate of Sciences (Medicine), Deputy Chief Physician for Drug Therapy, Associate Professor of the Department of Oncology and Radiation Diagnostics

Ekaterinburg

vpetkau@yandex.ruhttps://orcid.org/0000-0002-9935-4372АнкудиновН. О.AnkudinovN. O.

Николай Олегович Анкудинов — руководитель акушерского дистанционного консультативного центра, акушер-гинеколог высшей категории

Екатеринбург

Nikolay O. Ankudinov — Head of the Remote Obstetric Consultative Center

Ekaterinburg

79221588789@ya.ruhttps://orcid.org/0009-0001-4610-2120ДорофеевА. В.DorofeevA. V.

Александр Владимирович Дорофеев — доктор медицинских наук, заместитель главного врача по хирургии, доцент кафедры онкологии и лучевой диагностики

Екатеринбург

Alexander V. Dorofeev — Doctor of Sciences (Medicine), Deputy Chief Physician for Surgery, Associate Professor of the Department of Oncology and Radiation Diagnostics

Ekaterinburg

avdonco@gmail.comhttps://orcid.org/0000-0003-0038-887XЕфремовС. А.EfremovS. A.

Сергей Александрович Ефремов — директор

Екатеринбург

Sergey A. Efremov — Director

Ekaterinburg

s.efremov@oncor.proСвердловский областной онкологический диспансерРоссияSverdlovsk Regional Oncological CenterRussian FederationСвердловский областной онкологический диспансер; Уральский государственный медицинский университетРоссияSverdlovsk Regional Oncological Center; Ural State Medical UniversityRussian FederationЕкатеринбургский клинический перинатальный центрРоссияEkaterinburg Clinical Perinatal CenterRussian FederationООО «Бизнескомпьютер»РоссияBusinessComputer LLCRussian Federation202403092024234Специальный выпуск «Онкология»77–85Copyright © Киселева К.Е., Петкау В.В., Анкудинов Н.О., Дорофеев А.В., Ефремов С.А., 20242024Киселева К.Е., Петкау В.В., Анкудинов Н.О., Дорофеев А.В., Ефремов С.А.Kiselyova K.E., Petkau V.V., Ankudinov N.O., Dorofeev A.V., Efremov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1573Введение

Введение. В настоящее время отмечается увеличение заболеваемости раком молочной железы во время беременности, что, вероятно, связано с тенденцией к увеличению возраста родящих. Уровень заболеваемости злокачественными новообразованиями (ЗН) молочной железы, ассоциированными с беременностью, колеблется от 17,5 до 39,9 на 100 000 родов.

Цель исследования — выявить отличительные характеристики, оценить безрецидивную и общую выживаемость (ОВ) в группе пациенток с ЗН молочной железы, ассоциированными с беременностью.

Материалы и методы

Материалы и методы. Проанализированы результаты лечения 68 пациенток с диагнозом ЗН молочной железы, выявленным во время беременности либо в течение 12 месяцев после родов. В качестве группы сравнения проанализированы результаты лечения 165 пациенток с ЗН молочной железы в возрасте от 20 до 45 лет.

Результаты

Результаты. При сравнении гистологических типов опухолей в группе ЗН, ассоциированных с беременностью, статистически значимые различия наблюдались в группе тройных негативных подтипов. Однако при этом отсутствовали различия в отдаленной выживаемости между группами.

Выводы

Выводы. Наиболее часто встречающимся гистологическим подтипом при ЗН молочной железы, ассоциированных с беременностью, является тройной негативный, люминальные же подтипы встречаются реже, чем в популяции. Наблюдается тенденция к выявлению ЗН у беременных на более поздних стадиях. Влияние беременности на ОВ в настоящее время не до конца изучено, требуются дополнительные исследования о беременности как неблагоприятном факторе прогноза.

Introduction

Introduction. Currently, there is an increase in the incidence of breast cancer during pregnancy, which is likely due to the trend toward increasing age at childbirth. The incidence rate of pregnancy-associated breast cancer ranges from 17.5 to 39.9 per 100,000 births.

The purpose of our study is to identify distinctive characteristics, evaluate disease-free survival (RFS) and overall survival (OS) in a group of patients with pregnancy-associated breast cancer.

Materials and methods

Materials and methods. The results of treatment of 68 patients diagnosed with breast cancer detected during pregnancy or within 12 months after childbirth were analyzed. As a comparison group, the results of treatment of 165 patients aged from 20 to 45 years were analyzed.

Results

Results. When comparing the histological types of tumors in the group of pregnancy-associated malignancies, statistically significant differences were observed in the group of triple negative subtypes. However, there were no differences in long-term survival between groups.

Conclusions

Conclusions. The most common histological subtype in breast cancer associated with pregnancy is triple negative, while luminal subtypes are less common than in the general population. There is a tendency to detect cancer in pregnant women at later stages. The effect of pregnancy on OS is currently not fully understood and additional research is required on pregnancy as an unfavorable prognostic factor.

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The authors declare that there are no conflicts of interest present.