urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.23.6.45HEGGAZurmj-1641Research ArticleОригинальные статьи | Original articlesOriginal articlesОценка полиморбидности пациентов с COVID-19 и полиморфизмами C807T гена ITGA2 и T1565C гена ITGB3Assessment of Multimorbidity in Patients with COVID-19 and Polymorphisms C807T of the ITGA2 Gene and T1565C of the ITGB3 Genehttps://orcid.org/0000-0002-2623-2657КадниковЛ. И.KadnikovL. I.

Леонид Игоревич Кадников — аспирант кафедры фармакологии и клинической фармакологии

Екатеринбург

Leonid I. Kadnikov — Postgraduate Student of the Department of Pharmacology and Clinical Pharmacology

Ekaterinburg

kadn-leonid@mail.ruhttps://orcid.org/0000-0001-7826-9657ИзможероваН. В.IzmozherovaN. V.

Надежда Владимировна Изможерова — доктор медицинских наук, доцент, заведующий кафедрой фармакологии и клинической фармакологии, директор, институт клинической фармакологии и фармации

Екатеринбург

Nadezhda V. Izmozherova — Doctor of Sciences (Medicine), Associate Professor, Head of the Department of Pharmacology and Clinical Pharmacology, Director, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

nadezhda_izm@mail.ruhttps://orcid.org/0000-0001-6216-2468ПоповА. А.PopovA. A.

Артём Анатольевич Попов — доктор медицинских наук, доцент, заведующий кафедрой госпитальной терапии

Екатеринбург

Artem A. Popov — Doctor of Sciences (Medicine), Associate Professor, Head of the Department of Hospital Therapy

Ekaterinburg

art_popov@mail.ruhttps://orcid.org/0000-0002-9957-2505АнтроповаИ. П.AntropovaI. P.

Ирина Петровна Антропова — доктор биологических наук, ведущий научный сотрудник центральной научно-исследовательской лаборатории

Екатеринбург

Irina P. Antropova — Doctor of Sciences (Biology), Leading Researcher of the Central Research Laboratory

Ekaterinburg

aip.hemolab@mail.ruhttps://orcid.org/0000-0003-2797-1926КудрявцеваЕ. В.KudryavtsevaE. V.

Елена Владимировна Кудрявцева — доктор медицинских наук, доцент, заведующий центральной научно-исследовательской лабораторией

Екатеринбург

Elena V. Kudryavtseva — Doctor of Sciences (Medicine), Associate Professor, Head of the Central Research Laboratory

Ekaterinburg

elenavladpopova@yandex.ruУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation20241112202423645–57Copyright © Кадников Л.И., Изможерова Н.В., Попов А.А., Антропова И.П., Кудрявцева Е.В., 20242024Кадников Л.И., Изможерова Н.В., Попов А.А., Антропова И.П., Кудрявцева Е.В.Kadnikov L.I., Izmozherova N.V., Popov A.A., Antropova I.P., Kudryavtseva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1641Введение

Введение. Полиморфизм C807T гена ITGA2 и T1565C гена ITGB3 оказывает влияние на развитие многих сердечно-сосудистых заболеваний и может утяжелять состояние пациентов с COVID-19.

Цель работы — определить структуру полиморбидности у пациентов с коронавирусной инфекцией и полиморфизмами C807T гена ITGA2 и T1565C гена ITGB3.

Материалы и методы

Материалы и методы. Проведено исследование «случай — контроль»: группа 1 — 25 пациентов с COVID-19; группа 2 — 25 пациентов с COVID-19 и острым коронарным синдромом (ОКС). Группы соизмеримы по возрасту, объему поражения легких, индексу массы тела, длительности пребывания в стационаре. Генетическое исследование выполнено с помощью детектирующего амплификатора DTprime (ДТ-96).

Результаты

Результаты. Хроническая сердечная недостаточность в группе 1 встречалась у 6 пациентов с вариантом CC гена ITGA2 C807T, 8 — с CT и TT; группе 2 — 12 и 7 соответственно (p = 0,036). Острый инфаркт миокарда в анамнезе в группе 1 имел 1 пациент с вариантом CC гена ITGA2 C807T, 0 — с CT и TT; группе 2 — 2 и 9 соответственно (p < 0,001). Ожирение наблюдалось в группе 1 у 8 пациентов с вариантом CC гена ITGA2 C807T, 1 — с CT и TT; группе 2 — 7 и 3 соответственно (p = 0,006). Полиморфизм ITGB3 T1565C не оказывал влияния на полиморбидность.

Обсуждение

Обсуждение. Отмечено существование тесной связи между полиморфизмом C807T гена ITGA2 и развитием повторного, после перенесенного инфаркта миокарда, поражения сердечной мышцы и хронической сердечной недостаточности на фоне системного воспалительного процесса, гиперактивации тромбоцитарного звена гемостаза и фиброза. Влияние ITGA2 C807T на ожирение требует дальнейшего изучения.

Заключение

Заключение. Полученные данные свидетельствуют о существенном влиянии полиморфизма C807T гена ITGA2 и отсутствии влияния полиморфизма T1565C гена ITGB3 на полиморбидность пациентов с COVID-19.

Introduction

Introduction. ITGA2 gene C807T and ITGB3 gene T1565C polymorphisms influence the development of cardiovascular conditions and may worsen the condition of patients with COVID-19.

The aim of this study was to evaluate the multimorbidity in COVID-19 patients with ITGA2 gene C807T and ITGB3 gene T1565C polymorphisms.

Materials and methods

Materials and methods. The case-control study was conducted: group 1 included 25 patients with COVID-19; group 2 — 25 patients with COVID-19 and acute coronary syndrome. The groups were adjusted by age, volume of lung lesions, body mass index, terms of hospital stay. The genetic study was performed on a DTprime (DT-96) detection amplifier.

Results

Results. In Group 1, chronic heart failure occurred in 6 CC patients of ITGA2 gene, 8 — with T allele; in Group 2 — 12 and 7 patients, respectively (p = 0.036). Previous acute myocardial infarction occurred in 1 CC patient, no persons with T allele; in Group 2 — 2 and 9 cases, respectively (p < 0.001). In Group 1, obesity occurred in 8 CC patients, 1 — with T allele; in Group 2 — 7 and 3 cases, respectively (p = 0.006). The ITGB3 gene polymorphism had no effect on the multimorbidity.

Discussion

Discussion. There is a close connection between the ITGA2 (C807T) polymorphism and the development of recurrent myocardial infarction and chronic heart failure against the background of the existing systemic inflammatory process, platelet hyperactivation and fibrosis.

Conclusion

Conclusion. The data obtained indicate a significant influence of ITGA2 (C807T) gene polymorphism and the absence of an influence of ITGB3 (T1565C) gene polymorphism on the multimorbidity of patients with COVID-19.

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The authors declare that there are no conflicts of interest present.