urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.24.1.142QPAAABurmj-1731Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsСовременные методы фармакологической коррекции диабетической полинейропатииModern Methods of Pharmacological Correction of Diabetic Polyneuropathyhttps://orcid.org/0000-0001-8380-0289ЦепелевВ. Ю.TsepelevV. Yu.

Василий Юрьевич Цепелев — кандидат медицинских наук, доцент кафедры фармакологии

Курск

Vasily Yu. Tsepelev — Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology

Kursk

cepelevvyu@kursksmu.nethttps://orcid.org/0000-0002-1002-524XМасалеваИ. О.MasalevaI. O.

Ирина Олеговна Масалева — кандидат медицинских наук, доцент кафедры неврологии и нейрохирургии

Курск

Irina O. Masaleva — Candidate of Sciences (Medicine), Associate Professor of the Department of Neurology and Neurosurgery

Kursk

masalevs@mail.ruhttps://orcid.org/0009-0006-4301-2951БолдинаН. В.BoldinaN. V.

Наталья Владимировна Болдина — кандидат медицинских наук, доцент кафедры фармакологии

Курск

Natalia V. Boldina — Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology

Kursk

natalja.bldina@rambler.ruhttps://orcid.org/0009-0003-2717-6348ПоляковаО. В.PolyakovaO. V.

Ольга Витальевна Полякова — кандидат медицинских наук, доцент кафедры фармакологии

Курск

Olga V. Polyakova — Candidate of Sciences (Medicine), Associate Professor of the Department of Pharmacology

Kursk

polyakovaov@kursksmu.nethttps://orcid.org/0000-0001-9340-3850ГуновС. В.GunovS. V.

Станислав Викторович Гунов — студент лечебного факультета

Курск

Stanislav V. Gunov — Student of the Faculty of General Medicine

Kursk

gunov99@yandex.ruКурский государственный медицинский университетРоссияKursk State Medical UniversityRussian Federation202503032025241142–158Copyright © Цепелев В.Ю., Масалева И.О., Болдина Н.В., Полякова О.В., Гунов С.В., 20252025Цепелев В.Ю., Масалева И.О., Болдина Н.В., Полякова О.В., Гунов С.В.Tsepelev V.Y., Masaleva I.O., Boldina N.V., Polyakova O.V., Gunov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1731

Введение. Типичная диабетическая сенсомоторная полинейропатия — это одно из осложнений сахарного диабета, встречающееся у 50 % пациентов с этой патологией. Диабетическая нейропатия как осложнение сахарного диабета требует дополнительной медикаментозной коррекции для улучшения качества жизни больных.Цель работы — изучить современные подходы и эффективность фармакологической коррекции диабетической полинейропатии на основании данных научной литературы за последние 10 лет.Материалы и методы. Анализ и систематизация научных публикаций, размещенных в базах данных PubMed, Scopus, Web of Science за 2014–2023 гг.Результаты и обсуждение. В работе представлена клиническая характеристика типичной диабетической полинейропатии. Особый акцент уделяется фармакологической коррекции и рассмотрению большинства классов препаратов, способных купировать болевой синдром. Тактика лечения выстраивается не только на купировании основных симптомов, но и устранении патофизиологического компонента заболевания. Однако лечение строится не только на симптоматической терапии, но и устранении патогенетических звеньев этой патологии.Заключение. Диабетическая полинейропатия — грозное осложнение у лиц, страдающих сахарным диабетом. Основная задача лечения — купирование болевого синдрома и профилактика развития осложнений. Коррекция обеспечивается обширным выбором фармакологических препаратов.

Introduction. Typical diabetic sensorimotor polyneuropathy is one of the complications of diabetes mellitus, occurring in 50 % of patients with this pathology. Diabetic neuropathy as a complication of diabetes mellitus requires additional drug correction in order to improve the quality of life.The aim of the work is to study modern approaches and the effectiveness of pharmacological correction of diabetic polyneuropathy based on scientific literature data over the past 10 years. Materials and methods. Analysis and systematization of scientific publications posted in the PubMed, Scopus, Web of Science databases for 2014–2023.Results and discussion. The work presents the clinical characteristics of typical diabetic polyneuropathy. Particular emphasis is placed on pharmacological correction and consideration of most classes of drugs that can relieve pain. Treatment tactics are built not only on relieving the main symptoms, but also on eliminating the pathophysiological component of the disease. However, treatment is based not only on symptomatic therapy, but also on the elimination of pathogenetic links of this pathology.Conclusion. Diabetic polyneuropathy is a formidable complication in people suffering from diabetes mellitus. The main goal of treatment is to relieve pain and prevent the development of complications. Correction is provided by a wide range of pharmacological drugs.

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The authors declare that there are no conflicts of interest present.