urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.24.2.71JDGSPPurmj-1778Research ArticleОригинальные статьи | Original articlesOriginal articlesИзменение ядрышковой активности в условиях микросателлитной нестабильности в слизистой оболочке матки при предраке и раке эндометрияChanges in Nucleolar Activity Under Conditions of Microsatellite Instability in the Uterine Mucosa in Precancer and Endometrial Cancerhttps://orcid.org/0000-0002-9245-3749ЗатворницкаяА. В.ZatvornickayaA. V.

Александра Вадимовна Затворницкая — кандидат медицинских наук, ассистент кафедры патологической анатомии и судебной медицины имени профессора В. Л. Коваленко.

Челябинск

Alexandra V. Zatvornickaya — Candidate of Sciences (Medicine), Assistant of the Department of Pathological Anatomy and Forensic Medicine named after professor V. L. Kovalenko.

Chelyabinsk

monostyle@list.ruhttps://orcid.org/0000-0002-2008-7671КазачковЕ. Л.KazachkovE. L.

Евгений Леонидович Казачков — доктор медицинских наук, профессор, заведующий кафедрой патологической анатомии и судебной медицины имени профессора В. Л. Коваленко.

Челябинск

Evgeniy L. Kazachkov — Doctor of Sciences (Medicine), Professor, Head of the Department of Pathological Anatomy and Forensic Medicine named after professor V.L. Kovalenko.

Chelyabinsk

doctorkel@yandex.ruhttps://orcid.org/0000-0002-1175-4479КазачковаЭ. А.KazachkovaE. A.

Элла Алексеевна Казачкова — доктор медицинских наук, профессор, профессор кафедры акушерства и гинекологии.

Челябинск

Ella A. Kazachkova — Doctor of Sciences (Medicine), Professor, Professor of the Department of Obstetrics and Gynecology.

Chelyabinsk

kazachkovaea@yandex.ruЮжно‑Уральский государственный медицинский университетРоссияSouth Ural State Medical UniversityRussian Federation20250505202524271–83Copyright © Затворницкая А.В., Казачков Е.Л., Казачкова Э.А., 20252025Затворницкая А.В., Казачков Е.Л., Казачкова Э.А.Zatvornickaya A.V., Kazachkov E.L., Kazachkova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1778Актуальность

Актуальность. Анализ гистохимических характеристик пролиферативной активности эндометрия в случае микросателлитной нестабильности в образцах эндометрия у женщин с предраковыми изменениями является важным для клинической практики. Это исследование может помочь в более точной оценке риска малигнизации и выборе оптимальной стратегии наблюдения и лечения для пациенток с такой патологией.

Цель исследования — анализ состояния ядрышковых организаторов при наличии микросателлитной нестабильности в эндометриальной ткани у женщин, страдающих от предрака и рака тела матки, с сопоставлением данных.

Материалы и методы

Материалы и методы. В рамках работы проведено ретроспективное нерандомизированное исследование, осуществленное в один этап, с использованием гистологических, иммуногистохимических методов, а также статистического анализа.

Результаты

Результаты. Установлено, что активность ядрышковых организаторов усиливается при микросателлитной нестабильности, что указывает на активизацию внутриклеточного белкового синтеза. Вышеуказанное содействует увеличению пролиферативного потенциала эпителиоцитов железистого и стромального компонентов эндометрия в условиях гиперплазии и карциномы.

Заключение

Заключение. Представленные результаты могут служить в качестве дополнительного критерия при выборе тактики лечения пациенток с предраковыми изменениями и раком эндометрия.

Introduction

Introduction. The study of histochemical features of the proliferative activity of the endometrium in conditions of microsatellite instability in the endometrium in women with precancerous damage to the mucous membrane is of clinical interest for determining the prognosis of malignancy and tactics of managing patients with this pathology.

The aim of the study was to analyze the state of the nucleolar organizer system in conditions of microsatellite instability in the uterine mucosa in patients with precancer and endometrial cancer in a comparative aspect.

Materials and methods

Materials and methods. A one-stage non-randomized retrospective study was performed using histological, immunohistochemical and statistical methods.

Results

Results. An increase in the activity of nucleolar organizers was established in microsatellite instability, indicating an increase in protein-synthetic activity in cells and, as a consequence, the proliferative potential of glandular epithelial cells and endometrial stromal cells in its hyperplasia and carcinoma.

Conclusion

Conclusion. The obtained results can be used as an additional factor in determining the tactics of managing patients with precancer and endometrial cancer.

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The authors declare that there are no conflicts of interest present.