urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.24.2.109MPODUSurmj-1782Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsСравнение эффективности использования обогащенной тромбоцитами плазмы и гиалуроновой кислоты в лечении дегенеративных заболеваний коленных суставов за 12 месяцев терапии по результатам визуально-аналоговой шкалы болиComparison of the Efficacy of Platelet-Rich Plasma and Hyaluronic Acid in the Treatment of Degenerative Knee Diseases Over 12 Months of Therapy According to the Results of the Visual Analogue Pain Scalehttps://orcid.org/0000-0002-8104-0017ШтановаА. А.ShtanovaA. A.

Александра Александровна Штанова — ординатор.

Москва

Aleksandra A. Shtanova — Resident.

Moscow

alekshtanova@gmail.comhttps://orcid.org/0000-0001-5365-7792СтепинаД. А.StepinaD. A.

Дарья Артёмовна Степина — студент института хирургии.

Екатеринбург

Daria A. Stepina — Specialist’s Degree Student of the Institute of Surgery.

Ekaterinburg

d.stepina37@gmail.comhttps://orcid.org/0000-0002-6331-0124СивковаН. И.SivkovaN. I.

Надежда Ивановна Сивкова — кандидат социологических наук, доцент кафедры политических наук, Уральский гуманитарный институт.

Екатеринбург

Nadezhda I. Sivkova — Candidate of Sciences (Sociology), Associate Professor of the Department of Political Studies, Ural Institute of Humanities.

Ekaterinburg

letica@mail.ruhttps://orcid.org/0000-0003-1261-3712ЖиляковА. В.ZhilyakovA. V.

Андрей Викторович Жиляков — доктор медицинских наук, доцент кафедры травматологии и ортопедии, институт хирургии.

Екатеринбург

Andrey V. Zhilyakov — Doctor of Sciences (Medicine), Associate Professor of the Department of Traumatology and Orthopedics, Institute of Surgery.

Ekaterinburg

doctor-zhilyakov@rambler.ruhttps://orcid.org/0000-0001-5994-8558ВолокитинаЕ. А.VolokitinaE. A.

Елена Александровна Волокитина — доктор медицинских наук, профессор, заведующий кафедрой травматологии и ортопедии, институт хирургии.

Екатеринбург

Elena A. Volokitina — Doctor of Sciences (Medicine), Professor, Head of the Department of Traumatology and Orthopedics.

Ekaterinburg

volokitina_elena@rambler.ruФедеральное бюро медико‑социальной экспертизыРоссияFederal Bureau of Medical and Social ExpertiseRussian FederationУральский государственный медицинский университетРоссияUral State Medical UniversityRussian FederationУральский федеральный университет имени первого Президента России Б.Н. ЕльцинаРоссияUral Federal University named after the first President of Russia B.N. YeltsinRussian Federation202505052025242109–128Copyright © Штанова А.А., Степина Д.А., Сивкова Н.И., Жиляков А.В., Волокитина Е.А., 20252025Штанова А.А., Степина Д.А., Сивкова Н.И., Жиляков А.В., Волокитина Е.А.Shtanova A.A., Stepina D.A., Sivkova N.I., Zhilyakov A.V., Volokitina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/1782Введение

Введение. Основными методами местного лечения остеоартрита коленного сустава (ОАКС) являются инъекции гиалуроновой кислоты (ГК) и обогащенной тромбоцитами плазмой (ОТП). Для объективизации эффективности этих методов часто используют визуально-аналоговую шкалу боли (ВАШ). До сих пор продолжаются дискуссии относительно того, какой из методов обладает наибольшей и продолжительной эффективностью в снижении болевого синдрома и улучшении функции сустава, что затрудняет осознанный выбор терапии.

Цель — определить эффективность лечения ОАКС, представленную через ВАШ, через 12 месяцев от начала внутрисуставного введения ОТП в сравнении с инъекциями ГК.

Материалы и методы

Материалы и методы. В работу включены только статьи на английском языке (с доступом к полным текстам) с описанием результатов лечения, представленных в виде ВАШ, пациентов, которые проходили лечение по поводу ОАКС с помощью ГК или ОТП в течение 12 месяцев.

Результаты

Результаты. Первоначально отобрано 196 статей по теме, после удаления дубликатов осталось 170 статей, из которых только 4 подошли под критерии включения. На основе метаанализа значений ВАШ через 12 месяцев после начала терапии определен размер эффекта Hedges’ g — 0,26 (без статистической значимости). Гетерогенность между исследованиями была очень высокой (I2 = 93,48 %). В ходе тестов на публикационное смещение существенная предвзятость публикаций не выявлена. Согласно анализу Trim and Fill отсутствующие исследования, требующие коррекции из-за публикационного смещения, не найдены. В метаанализе продемонстрирован разнонаправленный эффект при использовании ОТП в лечении дегенеративных заболеваний коленных суставов, при этом вес каждого исследования различался, что могло повлиять на общий результат.

Вывод

Вывод. Не выявлено значимых различий в результатах лечения ОАКС с применением ОТП и ГК через 12 месяцев.

Introduction

Introduction. The primary local treatments for knee osteoarthritis (OAKS) include hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. The visual analogue pain scale (VAS) is often used to assess their effectiveness. Ongoing debate persists regarding which method provides the most sustained efficacy in reducing pain and improving joint function, complicating therapeutic decisions.

Aim — to evaluate the efficacy of OACS treatment, as measured by VAS, 12 months after the initiation of intra-articular PRP injection compared to HA injection.

Materials and methods

Materials and methods. We included only English-language articles with full text available that presented treatment outcomes as VAS in patients treated for OACS with HA or PRP over a 12-month period.

Results

Results. A total of 196 articles were initially selected, with 170 remaining after removing duplicates, and 4 meeting inclusion criteria. Meta-analysis of VAS at 12 months post-therapy indicated a Hedges’ g effect size of 0.26, without statistical significance. Study heterogeneity was high (I 2 = 93.48 %). Publication bias tests found no significant bias, and Trim and Fill analysis identified no missing studies needing adjustment.

Conclusion

Conclusion. The study revealed no significant difference between PRP and HA in treating knee osteoarthritis over 12 months. The absence of publication bias supports the reliability of these findings.

гиалуроновая кислотабогатая тромбоцитами плазмаинъекции внутрисуставныеостеоартритколенный суставизмерение болирезультаты леченияметаанализhyaluronic acidplatelet-rich plasmainjections intra-articularosteoarthritiskneepain measurementtreatment outcomemeta-analysisReferencesHerrero-Beaumont G, Roman-Blas JA, Bruyère O, Cooper C, Kanis J, Maggi S, et al. Clinical settings in knee osteoarthritis: Pathophysiology guides treatment. Maturitas. 2016;96:547. DOI: https://doi.org/10.1016/j.maturitas.2016.11.013.Herrero-Beaumont G, Roman-Blas JA, Bruyère O, Cooper C, Kanis J, Maggi S, et al. Clinical settings in knee osteoarthritis: Pathophysiology guides treatment. Maturitas. 2016;96:547. DOI: https://doi.org/10.1016/j.maturitas.2016.11.013.Gherghel R, Iordan DA, Mocanu MD, Onu A, Onu I. Osteoarthritis is not a disease, but rather an accumulation of predisposing factors: A systematic review. Balneo and Physical Medicine Research Journal. 2021; 12(3):218–26. DOI: https://doi.org/10.12680/balneo.2021.441.Gherghel R, Iordan DA, Mocanu MD, Onu A, Onu I. Osteoarthritis is not a disease, but rather an accumulation of predisposing factors: A systematic review. Balneo and Physical Medicine Research Journal. 2021; 12(3):218–26. DOI: https://doi.org/10.12680/balneo.2021.441.Khairov TE, Gainullin VV. Efficacy, tolerability and safety of treatment with Artradol and Artracam in patients with stage I–II osteoarthritis large joints of the lower extremities. Ural Medical Journal. 2017;(3):120–122. (In Russ.). EDN: https://elibrary.ru/YLQCDD.Khairov TE, Gainullin VV. Efficacy, tolerability and safety of treatment with Artradol and Artracam in patients with stage I–II osteoarthritis large joints of the lower extremities. Ural Medical Journal. 2017;(3):120–122. (In Russ.). EDN: https://elibrary.ru/YLQCDD.O’Connell B, Wragg NM, Wilson SL. The use of PRP injections in the management of knee osteoarthritis. Cell and Tissue Research. 2019;376(2):143–152. DOI: https://doi.org/10.1007/s00441-019-02996-x.O’Connell B, Wragg NM, Wilson SL. The use of PRP injections in the management of knee osteoarthritis. Cell and Tissue Research. 2019;376(2):143–152. DOI: https://doi.org/10.1007/s00441-019-02996-x.Szwedowski D, Szczepanek J, Paczesny Ł, Zabrzyński J, Gagat M, Mobasheri A, et al. The effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis. International Journal of Molecular Sciences. 2021;22(11):5492. DOI: https://doi.org/10.3390/ijms22115492.Szwedowski D, Szczepanek J, Paczesny Ł, Zabrzyński J, Gagat M, Mobasheri A, et al. The effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis. International Journal of Molecular Sciences. 2021;22(11):5492. DOI: https://doi.org/10.3390/ijms22115492.Delgado D, Garate A, Vincent H, Bilbao AM, Patel R, Fiz N, et al. Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis. Journal of Clinical Orthopaedics and Trauma. 2019; 10(1):36–41. DOI: https://doi.org/10.1016/j.jcot.2018.09.017.Delgado D, Garate A, Vincent H, Bilbao AM, Patel R, Fiz N, et al. Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis. Journal of Clinical Orthopaedics and Trauma. 2019; 10(1):36–41. DOI: https://doi.org/10.1016/j.jcot.2018.09.017.Zeng N, Yan ZP, Chen XY, Ni GX. Infrapatellar fat pad and knee osteoarthritis. Aging and Disease. 2020; 11(5):1317–1328. DOI: https://doi.org/10.14336/AD.2019.1116.Zeng N, Yan ZP, Chen XY, Ni GX. Infrapatellar fat pad and knee osteoarthritis. Aging and Disease. 2020; 11(5):1317–1328. DOI: https://doi.org/10.14336/AD.2019.1116.Ko S. Disentanglement of latent factors of radiographic knee images for knee osteoarthritis severity classification. Journal of Student Research. 2023;11(3). DOI: https://doi.org/10.47611/jsr.v11i3.1653.Ko S. Disentanglement of latent factors of radiographic knee images for knee osteoarthritis severity classification. Journal of Student Research. 2023;11(3). DOI: https://doi.org/10.47611/jsr.v11i3.1653.Scanzello CR. Role of low-grade inflammation in osteoarthritis. Current Opinion in Rheumatology. 2017; 29(1):79–85. DOI: https://doi.org/10.1097/BOR.0000000000000353.Scanzello CR. Role of low-grade inflammation in osteoarthritis. Current Opinion in Rheumatology. 2017; 29(1):79–85. DOI: https://doi.org/10.1097/BOR.0000000000000353.Aso K, Shahtaheri SM, Hill R, Wilson D, McWilliams DF, Walsh DA. Associations of symptomatic knee osteoarthritis with histopathologic features in subchondral bone. Arthritis and Rheumatology. 2019;71(6): 916–924. DOI: https://doi.org/10.1002/art.40820.Aso K, Shahtaheri SM, Hill R, Wilson D, McWilliams DF, Walsh DA. Associations of symptomatic knee osteoarthritis with histopathologic features in subchondral bone. Arthritis and Rheumatology. 2019;71(6): 916–924. DOI: https://doi.org/10.1002/art.40820.Sakata R, McNary SM, Miyatake K, Lee CA, Van den Bogaerde J, Marder RA, et al. Stimulation of the superficial zone protein and lubrication in the articular cartilage by human platelet-rich plasma. The American Journal of Sports Medicine. 2015;43(6):1467–1473. DOI: https://doi.org/10.1177/0363546515575023.Sakata R, McNary SM, Miyatake K, Lee CA, Van den Bogaerde J, Marder RA, et al. Stimulation of the superficial zone protein and lubrication in the articular cartilage by human platelet-rich plasma. The American Journal of Sports Medicine. 2015;43(6):1467–1473. DOI: https://doi.org/10.1177/0363546515575023.Eymard F, Ornetti P, Maillet J, Noel É, Adam P, Legré-Boyer V, et al. Intra-articular injections of platelet-rich plasma in symptomatic knee osteoarthritis: A consensus statement from French-speaking experts. Knee Surgery, Sports Traumatology, Arthroscopy. 2021;29(10):3195–3210. DOI: https://doi.org/10.1007/s00167-02006102-5.Eymard F, Ornetti P, Maillet J, Noel É, Adam P, Legré-Boyer V, et al. Intra-articular injections of platelet-rich plasma in symptomatic knee osteoarthritis: A consensus statement from French-speaking experts. Knee Surgery, Sports Traumatology, Arthroscopy. 2021;29(10):3195–3210. DOI: https://doi.org/10.1007/s00167-02006102-5.Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: Platelet-rich plasma, hyaluronic acid or ozone options. Knee Surgery, Sports Traumatology, Arthroscopy. 2017;25(2):485–492. DOI: https://doi.org/10.1007/s00167-016-4110-5.Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: Platelet-rich plasma, hyaluronic acid or ozone options. Knee Surgery, Sports Traumatology, Arthroscopy. 2017;25(2):485–492. DOI: https://doi.org/10.1007/s00167-016-4110-5.Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: A randomized controlled trial. The American Journal of Sports Medicine. 2015;43(7):1575–1582. DOI: https://doi.org/10.1177/0363546515582027.Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: A randomized controlled trial. The American Journal of Sports Medicine. 2015;43(7):1575–1582. DOI: https://doi.org/10.1177/0363546515582027.Papalia R, Zampogna B, Russo F, Vasta S, Tirindelli MC, Nobile C. et al. Comparing hybrid hyaluronic acid with PRP in end career athletes with degenerative cartilage lesions of the knee. Journal of Biological Regulators and Homeostatic Agents. 2016;30(4 Suppl 1):17–23. PMID: https://pubmed.gov/28002896.Papalia R, Zampogna B, Russo F, Vasta S, Tirindelli MC, Nobile C. et al. Comparing hybrid hyaluronic acid with PRP in end career athletes with degenerative cartilage lesions of the knee. Journal of Biological Regulators and Homeostatic Agents. 2016;30(4 Suppl 1):17–23. PMID: https://pubmed.gov/28002896.Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid et al.viscosupplementation as treatments for cartilage pathology: From early degeneration to osteoarthritis. Arthroscopy. 2011;27(11):1490–1501. DOI: https://doi.org/10.1016/j.arthro.2011.05.011.Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid et al.viscosupplementation as treatments for cartilage pathology: From early degeneration to osteoarthritis. Arthroscopy. 2011;27(11):1490–1501. DOI: https://doi.org/10.1016/j.arthro.2011.05.011.Su K, Bai Y, Wang J, Zhang H, Liu H, Ma S. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clinical Rheumatology. 2018;37(5):1341–1350. DOI: https://doi.org/10.1007/s10067-018-3985-6.Su K, Bai Y, Wang J, Zhang H, Liu H, Ma S. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clinical Rheumatology. 2018;37(5):1341–1350. DOI: https://doi.org/10.1007/s10067-018-3985-6.Huang HY, Hsu CW, Lin GC, Lin HS, Chou YJ, Liou IH, et al. Comparing efficacy of a single intraarticular injection of platelet-rich plasma (PRP) combined with different hyaluronans for knee osteoarthritis: A randomized-controlled clinical trial. BMC Musculoskeletal Disorders. 2022;23(1):954. DOI: https://doi.org/10.1186/s12891-022-05906-5.Huang HY, Hsu CW, Lin GC, Lin HS, Chou YJ, Liou IH, et al. Comparing efficacy of a single intraarticular injection of platelet-rich plasma (PRP) combined with different hyaluronans for knee osteoarthritis: A randomized-controlled clinical trial. BMC Musculoskeletal Disorders. 2022;23(1):954. DOI: https://doi.org/10.1186/s12891-022-05906-5.Jalali Jivan S, Monzavi SM, Zargaran B, Hamidi Alamdari D, Tavakol Afshari J, Etemad-Rezaie A, et al. Comparative analysis of the effectiveness of intra-articular injection of platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: Results of an open-label trial. Archives of Bone and Joint Surgery. 2021;9(5):487–495. DOI: https://doi.org/10.22038/abjs.2021.52003.2569.Jalali Jivan S, Monzavi SM, Zargaran B, Hamidi Alamdari D, Tavakol Afshari J, Etemad-Rezaie A, et al. Comparative analysis of the effectiveness of intra-articular injection of platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: Results of an open-label trial. Archives of Bone and Joint Surgery. 2021;9(5):487–495. DOI: https://doi.org/10.22038/abjs.2021.52003.2569.Nouri F, Babaee M, Peydayesh P, Esmaily H, Raeissadat SA. Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: A randomized clinical trial. BMC Musculoskeletal Disorders. 2022;23:856. DOI: https://doi.org/10.1186/s12891-022-05787-8.Nouri F, Babaee M, Peydayesh P, Esmaily H, Raeissadat SA. Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: A randomized clinical trial. BMC Musculoskeletal Disorders. 2022;23:856. DOI: https://doi.org/10.1186/s12891-022-05787-8.Chen L, Jin S, Yao Y, He S, He J. Comparison of clinical efficiency between intra-articular injection of platelet-rich plasma and hyaluronic acid for osteoarthritis: A meta-analysis of randomized controlled trials. Therapeutic Advances in Musculoskeletal Disease. 2023;15:1759–1769. DOI: https://doi.org/10.1177/1759720X231157043.Chen L, Jin S, Yao Y, He S, He J. Comparison of clinical efficiency between intra-articular injection of platelet-rich plasma and hyaluronic acid for osteoarthritis: A meta-analysis of randomized controlled trials. Therapeutic Advances in Musculoskeletal Disease. 2023;15:1759–1769. DOI: https://doi.org/10.1177/1759720X231157043.Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A. PRP injections for the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Cartilage. 2021;13(1 Suppl):364–375. DOI: https://doi.org/10.1177/1947603520931170.Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A. PRP injections for the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Cartilage. 2021;13(1 Suppl):364–375. DOI: https://doi.org/10.1177/1947603520931170.Tang JZ, Nie MJ, Zhao JZ, Zhang GC, Zhang Q, Wang B. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Journal of Orthopaedic Surgery and Research. 2020; 15(1):403. DOI: https://doi.org/10.1186/s13018-020-01919-9.Tang JZ, Nie MJ, Zhao JZ, Zhang GC, Zhang Q, Wang B. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Journal of Orthopaedic Surgery and Research. 2020; 15(1):403. DOI: https://doi.org/10.1186/s13018-020-01919-9.Belk JW, Lim JJ, Keeter C, McCulloch PC, Houck DA, McCarty EC. Patients with knee osteoarthritis who receive platelet-rich plasma or bone marrow aspirate concentrate injections have better outcomes than patients who receive hyaluronic acid: Systematic review and meta-analysis. Arthroscopy. 2023;39(7):1714–1734. DOI: https://doi.org/10.1016/j.arthro.2023.03.001.Belk JW, Lim JJ, Keeter C, McCulloch PC, Houck DA, McCarty EC. Patients with knee osteoarthritis who receive platelet-rich plasma or bone marrow aspirate concentrate injections have better outcomes than patients who receive hyaluronic acid: Systematic review and meta-analysis. Arthroscopy. 2023;39(7):1714–1734. DOI: https://doi.org/10.1016/j.arthro.2023.03.001.Qiao X, Yan L, Feng Y, Li X, Zhang K, Lv Z, et al. Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: A systematic review and network meta-analysis. BMC Musculoskeletal Disorders. 2023;24(1):926. DOI: https://doi.org/10.1186/s12891-023-06925-6.Qiao X, Yan L, Feng Y, Li X, Zhang K, Lv Z, et al. Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: A systematic review and network meta-analysis. BMC Musculoskeletal Disorders. 2023;24(1):926. DOI: https://doi.org/10.1186/s12891-023-06925-6.Migliorini F, Driessen A, Quack V, Sippel N, Cooper B, Mansy YE, et al. Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: A Bayesian network meta-analysis. Archives of Orthopaedic and Trauma Surgery. 2021;141(9):1473–1490. DOI: https://doi.org/10.1007/s00402-020-03551-y.Migliorini F, Driessen A, Quack V, Sippel N, Cooper B, Mansy YE, et al. Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: A Bayesian network meta-analysis. Archives of Orthopaedic and Trauma Surgery. 2021;141(9):1473–1490. DOI: https://doi.org/10.1007/s00402-020-03551-y.Zhao J, Huang H, Liang G, Zeng LF, Yang W, Liu J. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: A systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2020;21(1):224. DOI: https://doi.org/10.1186/s12891-020-03262-w.Zhao J, Huang H, Liang G, Zeng LF, Yang W, Liu J. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: A systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2020;21(1):224. DOI: https://doi.org/10.1186/s12891-020-03262-w.Anil U, Markus DH, Hurley ET, Manjunath AK, Alaia MJ, Campbell KA, et al. The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials. The Knee. 2021;32:173–182. DOI: https://doi.org/10.1016/j.knee.2021.08.008.Anil U, Markus DH, Hurley ET, Manjunath AK, Alaia MJ, Campbell KA, et al. The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials. The Knee. 2021;32:173–182. DOI: https://doi.org/10.1016/j.knee.2021.08.008.Costa LAV, Lenza M, Irrgang JJ, Fu FH, Ferretti M. How does platelet-rich plasma compare clinically to other therapies in the treatment of knee osteoarthritis? A systematic review and meta-analysis. The American Journal of Sports Medicine. 2023;51(13):1074–1086. DOI: https://doi.org/10.1177/03635465221140917.Costa LAV, Lenza M, Irrgang JJ, Fu FH, Ferretti M. How does platelet-rich plasma compare clinically to other therapies in the treatment of knee osteoarthritis? A systematic review and meta-analysis. The American Journal of Sports Medicine. 2023;51(13):1074–1086. DOI: https://doi.org/10.1177/03635465221140917.Xue Y, Wang X, Wang X, Huang L, Yao A, Xue Y. A comparative study of the efficacy of intra-articular injection of different drugs in the treatment of mild to moderate knee osteoarthritis: A network meta-analysis. Medicine. 2023;102(12):e33339. DOI: https://doi.org/10.1097/MD.0000000000033339.Xue Y, Wang X, Wang X, Huang L, Yao A, Xue Y. A comparative study of the efficacy of intra-articular injection of different drugs in the treatment of mild to moderate knee osteoarthritis: A network meta-analysis. Medicine. 2023;102(12):e33339. DOI: https://doi.org/10.1097/MD.0000000000033339.Singh H, Knapik DM, Polce EM, Eikani CK, Bjornstad AH, Gursoy S, et al. Relative efficacy of intra-articular injections in the treatment of knee osteoarthritis: A systematic review and network meta-analysis. The American Journal of Sports Medicine. 2022;50(11):3140–3148. DOI: https://doi.org/10.1177/03635465211029659.Singh H, Knapik DM, Polce EM, Eikani CK, Bjornstad AH, Gursoy S, et al. Relative efficacy of intra-articular injections in the treatment of knee osteoarthritis: A systematic review and network meta-analysis. The American Journal of Sports Medicine. 2022;50(11):3140–3148. DOI: https://doi.org/10.1177/03635465211029659.McLarnon M, Heron N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: Systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2021;22(1):550. DOI: https://doi.org/10.1186/s12891-021-04308-3.McLarnon M, Heron N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: Systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2021;22(1):550. DOI: https://doi.org/10.1186/s12891-021-04308-3.Jawanda H, Khan ZA, Warrier AA, Acuña AJ, Allahabadi S, Kaplan DJ, et al. Platelet-rich plasma, bone marrow aspirate concentrate, and hyaluronic acid injections outperform corticosteroids in pain and function scores at a minimum of 6 months as intra-articular injections for knee osteoarthritis: A systematic review and network meta-analysis. Arthroscopy. 2024;40(5):1623–1636.e1. DOI: https://doi.org/10.1016/j.arthro.2024.01.037.Jawanda H, Khan ZA, Warrier AA, Acuña AJ, Allahabadi S, Kaplan DJ, et al. Platelet-rich plasma, bone marrow aspirate concentrate, and hyaluronic acid injections outperform corticosteroids in pain and function scores at a minimum of 6 months as intra-articular injections for knee osteoarthritis: A systematic review and network meta-analysis. Arthroscopy. 2024;40(5):1623–1636.e1. DOI: https://doi.org/10.1016/j.arthro.2024.01.037.Zhao J, Liang G, Han Y, Yang W, Xu N, Luo M, et al. Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: A meta-analysis of randomised controlled trials. BMJ Open. 2022;12(11): e061008. DOI: https://doi.org/10.1136/bmjopen-2022-061008.Zhao J, Liang G, Han Y, Yang W, Xu N, Luo M, et al. Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: A meta-analysis of randomised controlled trials. BMJ Open. 2022;12(11): e061008. DOI: https://doi.org/10.1136/bmjopen-2022-061008.Abbas A, Du JT, Dhotar HS. The effect of leukocyte concentration on platelet-rich plasma injections for knee osteoarthritis: A network meta-analysis. The Journal of Bone and Joint Surgery. American Volume. 2022; 104(6):559–570. DOI: https://doi.org/10.2106/JBJS.20.02258.Abbas A, Du JT, Dhotar HS. The effect of leukocyte concentration on platelet-rich plasma injections for knee osteoarthritis: A network meta-analysis. The Journal of Bone and Joint Surgery. American Volume. 2022; 104(6):559–570. DOI: https://doi.org/10.2106/JBJS.20.02258.Kim JH, Park YB, Ha CW. Are leukocyte-poor or multiple injections of platelet-rich plasma more effective than hyaluronic acid for knee osteoarthritis? A systematic review and meta-analysis of randomized controlled trials. Archives of Orthopaedic and Trauma Surgery. 2023;143(7):3879–3897. DOI: https://doi.org/10.1007/s00402-022-04637-5.Kim JH, Park YB, Ha CW. Are leukocyte-poor or multiple injections of platelet-rich plasma more effective than hyaluronic acid for knee osteoarthritis? A systematic review and meta-analysis of randomized controlled trials. Archives of Orthopaedic and Trauma Surgery. 2023;143(7):3879–3897. DOI: https://doi.org/10.1007/s00402-022-04637-5.Tao X, Aw AAL, Leeu JJ, Bin Abd Razak HR. Three doses of platelet-rich plasma therapy are more effective than one dose of platelet-rich plasma in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Arthroscopy. 2023;39(12):2568–2576.e2. DOI: https://doi.org/10.1016/j.arthro.2023.05.018.Tao X, Aw AAL, Leeu JJ, Bin Abd Razak HR. Three doses of platelet-rich plasma therapy are more effective than one dose of platelet-rich plasma in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Arthroscopy. 2023;39(12):2568–2576.e2. DOI: https://doi.org/10.1016/j.arthro.2023.05.018.Oeding JF, Varady NH, Fearington FW, Pareek A, Strickland SM, Nwachukwu BU, et al. Platelet-rich plasma versus alternative injections for osteoarthritis of the knee: A systematic review and statistical fragility index-based meta-analysis of randomized controlled trials. The American Journal of Sports Medicine. 2024; 52(12):3147–3160. DOI: https://doi.org/10.1177/03635465231224463.Oeding JF, Varady NH, Fearington FW, Pareek A, Strickland SM, Nwachukwu BU, et al. Platelet-rich plasma versus alternative injections for osteoarthritis of the knee: A systematic review and statistical fragility index-based meta-analysis of randomized controlled trials. The American Journal of Sports Medicine. 2024; 52(12):3147–3160. DOI: https://doi.org/10.1177/03635465231224463.Ta CN, Vasudevan R, Mitchell BC, Keller RA, Kent WT. The influence of industry affiliation on randomized controlled trials of platelet-rich plasma for knee osteoarthritis. The American Journal of Sports Medicine. 2023;51(13):3583–3590. DOI: https://doi.org/10.1177/03635465221140917.Ta CN, Vasudevan R, Mitchell BC, Keller RA, Kent WT. The influence of industry affiliation on randomized controlled trials of platelet-rich plasma for knee osteoarthritis. The American Journal of Sports Medicine. 2023;51(13):3583–3590. DOI: https://doi.org/10.1177/03635465221140917.Zhang Q, Liu T, Gu Y, Gao Y, Ni J. Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone for knee osteoarthritis: A systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research. 2022;17(1):499. DOI: https://doi.org/10.1186/s13018-02203398-6.Zhang Q, Liu T, Gu Y, Gao Y, Ni J. Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone for knee osteoarthritis: A systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research. 2022;17(1):499. DOI: https://doi.org/10.1186/s13018-02203398-6.Simental-Mendía M, Ortega-Mata D, Tamez-Mata Y, Olivo CAA, Vilchez-Cavazos F. Comparison of the clinical effectiveness of activated and non-activated platelet-rich plasma in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Clinical Rheumatology. 2023;42(5):1397–1408. DOI: https://doi.org/10.1007/s10067-022-06463-x.Simental-Mendía M, Ortega-Mata D, Tamez-Mata Y, Olivo CAA, Vilchez-Cavazos F. Comparison of the clinical effectiveness of activated and non-activated platelet-rich plasma in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Clinical Rheumatology. 2023;42(5):1397–1408. DOI: https://doi.org/10.1007/s10067-022-06463-x.Wu Q, Luo X, Xiong Y, Liu G, Wang J, Chen X, et al. Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection. Journal of Orthopaedic Surgery. 2020; 28(1):2309499019887660. DOI: https://doi.org/10.1177/2309499019887660.Wu Q, Luo X, Xiong Y, Liu G, Wang J, Chen X, et al. Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection. Journal of Orthopaedic Surgery. 2020; 28(1):2309499019887660. DOI: https://doi.org/10.1177/2309499019887660.Vilchez-Cavazos F, Blázquez-Saldaña J, Gamboa-Alonso AA, Peña-Martínez VM, Acosta-Olivo CA, Sánchez-García A, et al. The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials. Archives of Orthopaedic and Trauma Surgery. 2023;143 (3):1393–1408. DOI: https://doi.org/10.1007/s00402-02104304-1.Vilchez-Cavazos F, Blázquez-Saldaña J, Gamboa-Alonso AA, Peña-Martínez VM, Acosta-Olivo CA, Sánchez-García A, et al. The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials. Archives of Orthopaedic and Trauma Surgery. 2023;143 (3):1393–1408. DOI: https://doi.org/10.1007/s00402-02104304-1.Yang B, Ma J. Meta-analysis of the efficacy and safety of arthroscopic surgery associated with platelet-rich plasma infusion when treating knee osteoarthritis. International Journal of Rheumatic Diseases. 2023; 26(11):2248–2257. DOI: https://doi.org/10.1111/1756-185X.14921.Yang B, Ma J. Meta-analysis of the efficacy and safety of arthroscopic surgery associated with platelet-rich plasma infusion when treating knee osteoarthritis. International Journal of Rheumatic Diseases. 2023; 26(11):2248–2257. DOI: https://doi.org/10.1111/1756-185X.14921.Sax OC, Chen Z, Mont MA, Delanois RE. The efficacy of platelet-rich plasma for the treatment of knee osteoarthritis symptoms and structural changes: A systematic review and meta-analysis. The Journal of Arthroplasty. 2022;37(11):2282–2290.e2. DOI: https://doi.org/10.1016/j.arth.2022.05.014.Sax OC, Chen Z, Mont MA, Delanois RE. The efficacy of platelet-rich plasma for the treatment of knee osteoarthritis symptoms and structural changes: A systematic review and meta-analysis. The Journal of Arthroplasty. 2022;37(11):2282–2290.e2. DOI: https://doi.org/10.1016/j.arth.2022.05.014.Hong M, Cheng C, Sun X, Yan Y, Zhang Q, Wang W, et al. Efficacy and safety of intra-articular platelet-rich plasma in osteoarthritis knee: A systematic review and meta-analysis. BioMed Research International. 2021:2191926. DOI: https://doi.org/10.1155/2021/2191926.Hong M, Cheng C, Sun X, Yan Y, Zhang Q, Wang W, et al. Efficacy and safety of intra-articular platelet-rich plasma in osteoarthritis knee: A systematic review and meta-analysis. BioMed Research International. 2021:2191926. DOI: https://doi.org/10.1155/2021/2191926.Chen Z, Wang C, You D, Zhao S, Zhu Z, Xu M. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Medicine. 2020;99(11):e19388. DOI: https://doi.org/10.1097/MD.0000000000019388.Chen Z, Wang C, You D, Zhao S, Zhu Z, Xu M. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Medicine. 2020;99(11):e19388. DOI: https://doi.org/10.1097/MD.0000000000019388.Dong Y, Zhang B, Yang Q, Zhu J, Sun X. The effects of platelet-rich plasma injection in knee and hip osteoarthritis: A meta-analysis of randomized controlled trials. Clinical Rheumatology. 2021;40 (1):263–277. DOI: https://doi.org/10.1007/s10067-020-05185-2.Dong Y, Zhang B, Yang Q, Zhu J, Sun X. The effects of platelet-rich plasma injection in knee and hip osteoarthritis: A meta-analysis of randomized controlled trials. Clinical Rheumatology. 2021;40 (1):263–277. DOI: https://doi.org/10.1007/s10067-020-05185-2.Gao J, Ma Y, Tang J, Zhang J, Zuo J. Efficacy and safety of platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: A systematic review and meta-analysis. Archives of Orthopaedic and Trauma Surgery. 2024;144(9):3947–3967. DOI: https://doi.org/10.1007/s00402-024-05442-y.Gao J, Ma Y, Tang J, Zhang J, Zuo J. Efficacy and safety of platelet-rich plasma and hyaluronic acid combination therapy for knee osteoarthritis: A systematic review and meta-analysis. Archives of Orthopaedic and Trauma Surgery. 2024;144(9):3947–3967. DOI: https://doi.org/10.1007/s00402-024-05442-y.Laohajaroensombat S, Prusmetikul S, Rattanasiri S, Thakkinstian A, Woratanarat P. Platelet-rich plasma injection for the treatment of ankle osteoarthritis: A systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research. 2023;18(1):373. DOI: https://doi.org/10.1186/s13018-023-03828-z.Laohajaroensombat S, Prusmetikul S, Rattanasiri S, Thakkinstian A, Woratanarat P. Platelet-rich plasma injection for the treatment of ankle osteoarthritis: A systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research. 2023;18(1):373. DOI: https://doi.org/10.1186/s13018-023-03828-z.Cao Y, Luo J, Han S, Li Z, Fan T, Zeng M, et al. A model-based quantitative analysis of efficacy and associated factors of platelet-rich plasma treatment for osteoarthritis. International Journal of Surgery. 2023; 109(6):1742–1752. DOI: https://doi.org/10.1097/JS9.0000000000000337.Cao Y, Luo J, Han S, Li Z, Fan T, Zeng M, et al. A model-based quantitative analysis of efficacy and associated factors of platelet-rich plasma treatment for osteoarthritis. International Journal of Surgery. 2023; 109(6):1742–1752. DOI: https://doi.org/10.1097/JS9.0000000000000337.Gong H, Li K, Xie R, Du G, Li L, Wang S, et al. Clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized double-blind controlled trials. Medicine. 2021;100(12): e25168. DOI: https://doi.org/10.1097/MD.0000000000025168.Gong H, Li K, Xie R, Du G, Li L, Wang S, et al. Clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized double-blind controlled trials. Medicine. 2021;100(12): e25168. DOI: https://doi.org/10.1097/MD.0000000000025168.Zhao D, Pan JK, Yang WY, Han YH, Zeng LF, Liang GH, et al. Intra-articular injections of platelet-rich plasma, adipose mesenchymal stem cells, and bone marrow mesenchymal stem cells associated with better outcomes than hyaluronic acid and saline in knee osteoarthritis: A systematic review and network meta-analysis. Arthroscopy. 2021;37(7):2298–2310.e10. DOI: https://doi.org/10.1016/j.arthro.2021.02.045.Zhao D, Pan JK, Yang WY, Han YH, Zeng LF, Liang GH, et al. Intra-articular injections of platelet-rich plasma, adipose mesenchymal stem cells, and bone marrow mesenchymal stem cells associated with better outcomes than hyaluronic acid and saline in knee osteoarthritis: A systematic review and network meta-analysis. Arthroscopy. 2021;37(7):2298–2310.e10. DOI: https://doi.org/10.1016/j.arthro.2021.02.045.Hohmann E, Tetsworth K, Glatt V. Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. European Journal of Orthopaedic Surgery & Traumatology. 2020;30(6):955–967. DOI: https://doi.org/10.1007/s00590-02002623-4.Hohmann E, Tetsworth K, Glatt V. Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. European Journal of Orthopaedic Surgery & Traumatology. 2020;30(6):955–967. DOI: https://doi.org/10.1007/s00590-02002623-4.Tan J, Chen H, Zhao L, Huang W. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis of 26 randomized controlled trials. Arthroscopy. 2021;37(1):309–325. DOI: https://doi.org/10.1016/j.arthro.2020.07.011.Tan J, Chen H, Zhao L, Huang W. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis of 26 randomized controlled trials. Arthroscopy. 2021;37(1):309–325. DOI: https://doi.org/10.1016/j.arthro.2020.07.011.Lim A, Zhu JB, Khanduja V. The use of intra-articular platelet-rich plasma as a therapeutic intervention for hip osteoarthritis: A systematic review and meta-analysis. The American Journal of Sports Medicine. 2023; 51(9):2487–2497. DOI: https://doi.org/10.1177/03635465221095563.Lim A, Zhu JB, Khanduja V. The use of intra-articular platelet-rich plasma as a therapeutic intervention for hip osteoarthritis: A systematic review and meta-analysis. The American Journal of Sports Medicine. 2023; 51(9):2487–2497. DOI: https://doi.org/10.1177/03635465221095563.Karasavvidis T, Totlis T, Gilat R, Cole BJ. Platelet-rich plasma combined with hyaluronic acid improves pain and function compared with hyaluronic acid alone in knee osteoarthritis: A systematic review and meta-analysis. Arthroscopy. 2021;37(4):1277–1287.e1. DOI: https://doi.org/10.1016/j.arthro.2020.11.052.Karasavvidis T, Totlis T, Gilat R, Cole BJ. Platelet-rich plasma combined with hyaluronic acid improves pain and function compared with hyaluronic acid alone in knee osteoarthritis: A systematic review and meta-analysis. Arthroscopy. 2021;37(4):1277–1287.e1. DOI: https://doi.org/10.1016/j.arthro.2020.11.052.Ding SL, Ji LF, Zhang MZ, Xiong W, Sun CY, Han ZY, et al. Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: A systematic review and meta-analysis. International Orthopaedics. 2023;47(8):1963–1974. DOI: https://doi.org/10.1007/s00264-023-05773-2.Ding SL, Ji LF, Zhang MZ, Xiong W, Sun CY, Han ZY, et al. Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: A systematic review and meta-analysis. International Orthopaedics. 2023;47(8):1963–1974. DOI: https://doi.org/10.1007/s00264-023-05773-2.Chou SH, Shih CL. Efficacy of different platelet-rich plasma injections in the treatment of mild-moderate knee osteoarthritis: A systematic review and meta-analysis. International Journal of Clinical Practice. 2021; 75(6): e14068. DOI: https://doi.org/10.1111/ijcp.14068.Chou SH, Shih CL. Efficacy of different platelet-rich plasma injections in the treatment of mild-moderate knee osteoarthritis: A systematic review and meta-analysis. International Journal of Clinical Practice. 2021; 75(6): e14068. DOI: https://doi.org/10.1111/ijcp.14068.Donovan RL, Edwards TA, Judge A, Blom AW, Kunutsor SK, Whitehouse MR. Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: A systematic review and meta-analysis in comparison to other injectables. Osteoarthritis and Cartilage. 2022;30(12):1658–1669. DOI: https://doi.org/10.1016/j.joca.2022.07.011.Donovan RL, Edwards TA, Judge A, Blom AW, Kunutsor SK, Whitehouse MR. Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: A systematic review and meta-analysis in comparison to other injectables. Osteoarthritis and Cartilage. 2022;30(12):1658–1669. DOI: https://doi.org/10.1016/j.joca.2022.07.011.Luo P, Xiong Z, Sun W, Shi L, Gao F, Li Z. How to choose platelet-rich plasma or hyaluronic acid for the treatment of knee osteoarthritis in overweight or obese patients: A meta-analysis. Pain Research & Management. 2020;7587936. DOI: https://doi.org/10.1155/2020/7587936.Luo P, Xiong Z, Sun W, Shi L, Gao F, Li Z. How to choose platelet-rich plasma or hyaluronic acid for the treatment of knee osteoarthritis in overweight or obese patients: A meta-analysis. Pain Research & Management. 2020;7587936. DOI: https://doi.org/10.1155/2020/7587936.Zeng W, Wang G, Liao X, Pei C. Efficacy of intra-articular injection of platelet-rich plasma combined with mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis. International Journal of Clinical Practice. 2022:2192474. DOI: https://doi.org/10.1155/2022/2192474.Zeng W, Wang G, Liao X, Pei C. Efficacy of intra-articular injection of platelet-rich plasma combined with mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis. International Journal of Clinical Practice. 2022:2192474. DOI: https://doi.org/10.1155/2022/2192474.Boffa A, Previtali D, Di Laura Frattura G, Vannini F, Candrian C, Filardo G. Evidence on ankle injections for osteochondral lesions and osteoarthritis: A systematic review and meta-analysis. International Orthopaedics. 2021;45 (2):509–523. DOI: https://doi.org/10.1007/s00264-020-04689-5.Boffa A, Previtali D, Di Laura Frattura G, Vannini F, Candrian C, Filardo G. Evidence on ankle injections for osteochondral lesions and osteoarthritis: A systematic review and meta-analysis. International Orthopaedics. 2021;45 (2):509–523. DOI: https://doi.org/10.1007/s00264-020-04689-5.Medina-Porqueres I, Ortega-Castillo M, Muriel-Garcia A. Effectiveness of platelet-rich plasma in the management of hip osteoarthritis: A systematic review and meta-analysis. Clinical Rheumatology. 2021; 40(1):53–64. DOI: https://doi.org/10.1007/s10067-020-05241-x.Medina-Porqueres I, Ortega-Castillo M, Muriel-Garcia A. Effectiveness of platelet-rich plasma in the management of hip osteoarthritis: A systematic review and meta-analysis. Clinical Rheumatology. 2021; 40(1):53–64. DOI: https://doi.org/10.1007/s10067-020-05241-x.Belk JW, Houck DA, Littlefield CP, Kraeutler MJ, Potyk AG, Mei-Dan O, et al. Platelet-rich plasma versus hyaluronic acid for hip osteoarthritis yields similarly beneficial short-term clinical outcomes: A systematic review and meta-analysis of level I and II randomized controlled trials. Arthroscopy. 2022;38(6):2035–2046. DOI: https://doi.org/10.1016/j.arthro.2021.11.005.Belk JW, Houck DA, Littlefield CP, Kraeutler MJ, Potyk AG, Mei-Dan O, et al. Platelet-rich plasma versus hyaluronic acid for hip osteoarthritis yields similarly beneficial short-term clinical outcomes: A systematic review and meta-analysis of level I and II randomized controlled trials. Arthroscopy. 2022;38(6):2035–2046. DOI: https://doi.org/10.1016/j.arthro.2021.11.005.Tjandra KC, Novriansyah R, Sudiasa INS, Ar A, Rahmawati NAD, Dilogo IH. Modified mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches. PLoS One. 2024; 19(3): e0295876. DOI: https://doi.org/10.1371/journal.pone.0295876.Tjandra KC, Novriansyah R, Sudiasa INS, Ar A, Rahmawati NAD, Dilogo IH. Modified mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches. PLoS One. 2024; 19(3): e0295876. DOI: https://doi.org/10.1371/journal.pone.0295876.Ren H, Zhang S, Wang X, Li Z, Guo W. Role of platelet-rich plasma in the treatment of osteoarthritis: A meta-analysis. Journal of International Medical Research. 2020;48(10):0300060520964661. DOI: https://doi.org/10.1177/0300060520964661.Ren H, Zhang S, Wang X, Li Z, Guo W. Role of platelet-rich plasma in the treatment of osteoarthritis: A meta-analysis. Journal of International Medical Research. 2020;48(10):0300060520964661. DOI: https://doi.org/10.1177/0300060520964661.Phillips M, Vannabouathong C, Devji T, Patel R, Gomes Z, Patel A, et al. Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: A network meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy. 2020;28(9):3031–3039. DOI: https://doi.org/10.1007/s00167019-05763-1.Phillips M, Vannabouathong C, Devji T, Patel R, Gomes Z, Patel A, et al. Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: A network meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy. 2020;28(9):3031–3039. DOI: https://doi.org/10.1007/s00167019-05763-1.

The authors declare that there are no conflicts of interest present.