Введение

urmj

Уральский медицинский журнал

Ural Medical Journal

2949-4389

Ural State Medical University

10.52420/umj.24.5.116

YHXYLD

urmj-1975

Research Article

Литературные обзоры | Literature reviews

Literature reviews

Урсодезоксихолевая кислота — многофункциональное средство в гастроэнтерологии

Ursodeoxycholic Acid is a Multifunctional Agent in Gastroenterology

https://orcid.org/0009-0003-0062-1181

Ковалёва

Н. Б.

Kovaleva

N. B.

Ковалёва Нина Борисовна — кандидат медицинских наук, доцент кафедры поликлинической терапии, институт клинической медицины.

Екатеринбург

Nina B. Kovaleva — Candidate of Sciences (Medicine), Associate Professor of the Department of Polyclinic Therapy, Institute of Clinical Medicine, Ural State Medical University.

Ekaterinburg

kovaleva-nb.nina@yandex.ru

Уральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation

2025

02112025

245

116–132

2025

Ковалёва Н.Б.

Kovaleva N.B.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.umjusmu.ru/jour/article/view/1975

Введение

Введение. Синтезированная в 1950-е гг. урсодезоксихолевая кислота (УДХК) является высокоэффективным лекарственным средством гепатопротекции. Диапазон присущих ей плейотропных свойств хорошо изучен — это литолитический, гипохолестатический, иммуномодулирующий, антиапоптический и другие эффекты.

Цель работы — обсуждение фармакологических эффектов УДХК и результатов ее клинического применения при наиболее распространенных заболеваниях печени и желчного пузыря.

Материалы и методы

Материалы и методы. Для составления обзора использованы российские и зарубежные публикации, которые отбирались по принципу наилучшего соответствия целям работы и ключевым словам в электронных базах PubMed и eLibrary.ru, а также печатных источниках за период с 1981 г. по 2025 г.

Результаты и обсуждение

Результаты и обсуждение. Мультитаргетное профилактическое и лечебное влияния УДХК включает в себя гепатопротективный эффект при гепатитах вирусной и алкогольной этиологии, улучшение клинико-лабораторных показателей при холестазе, снижение уровня холестерина при неалкогольной жировой болезни печени, литолитическое действие при билиарном сладже и желчнокаменной болезни, а также потенциальную способность к онкопревенции печени и всего пищеварительного тракта.

Заключение

Заключение. УДХК обладает целым спектром положительных эффектов при гепатобилиарной патологии и некоторых других заболеваниях. Многокомпонентное действие наряду с высоким профилем безопасности позволяют широко использовать препарат в лечебной практике коморбидных пациентов гастроэнтерологического профиля.

Introduction

Introduction. Synthesized in the 1950s, ursodeoxycholic acid (UDCA) is a highly effective hepatoprotective drug. UDCA is well known for its pleiotropic properties with litholytic, hypocholestatic, immunomodulatory, antiapoptotic and other effects.

The purpose of the work is to discuss the pharmacological effects of UDCA and its clinical use in the most common liver and gallbladder diseases.

Materials and methods

Materials and methods. This is a narrative review of the most relevant national and foreign publications focused on UDCA. The literature search was performed in PubMed, eLibrary.ru and printed sources from 1981 to 2025.

Results and discussion

Results and discussion. Multitarget prophylactic and therapeutic action of UDCA includes hepatoprotective effect in viral and alcoholic hepatitis, improvement of clinical and laboratory parameters in cholestasis, a decrease in cholesterol levels in non-alcoholic fatty liver disease, a litholytic effect in biliary sludge and cholelithiasis, and a potential ability to prevent cancer of the liver and the entire digestive tract.

Conclusion

Conclusion. UDCA has a broad spectrum of the beneficial effects in hepatobiliary and concomitant cardiometabolic pathology. Multitarget action together with high safety profile allow the drug to be widely used in the treatment of comorbid gastroenterological patients.

урсодезоксихолевая кислотагепатопротекцияхолестазнеалкогольная жировая болезнь печениалкогольная жировая болезнь печени

ursodeoxycholic acidhepatoprotectioncholestasisnonalcoholic fatty liver diseasealcoholic fatty liver disease

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The authors declare that there are no conflicts of interest present.