urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.24.6.63PCFKXRurmj-2034Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsФакторы, ассоциированные с развитием лекарственно‑индуцированной головной боли: литературный обзорFactors Associated with the Development of Medication Overuse Headache: A Literature Reviewhttps://orcid.org/0009-0009-6211-0428КнязеваЯ. А.KniazevaI. A.

Яна Алексеевна Князева – аспирант кафедры госпитальной терапии, институт клинической медицины

Екатеринбург

Iana A. Kniazeva – Postgraduate Student of the Department of Hospital Therapy, Institute of ClinicalMedicine

Ekaterinburg

neuro_k@mail.ruhttps://orcid.org/0000-0003-2463-7113ЛебедеваЕ. Р.LebedevaE. R.

Елена Разумовна Лебедева – доктор медицинских наук, профессор кафедры госпитальной терапии, институт клинической медицины, руководитель, невролог

Екатеринбург

Elena R. Lebedeva – Doctor of Sciences (Medicine), Professor of the Department of Hospital Therapy, Institute of Clinical Medicine, Head, Consultant Neurologist

Ekaterinburg

cosmos@k66.ruУральский государственный медицинский университетРоссияUral State Medical UniversityRussian FederationУральский государственный медицинский университет; Международный центр лечения головных болей «Европа‑Азия»РоссияUral State Medical University; International Headache Centre “Europe-Asia"Russian Federation20252312202524663–81Copyright © Князева Я.А., Лебедева Е.Р., 20252025Князева Я.А., Лебедева Е.Р.Kniazeva I.A., Lebedeva E.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/2034Введение

Введение. В большинстве стран распространенность лекарственно-индуцированной головной боли (ЛИГБ) составляет 1–2 %, однако в России она встречается значительно чаще — 7,6 %. ЛИГБ становится причиной социальной дезадаптации пациентов, снижает качество жизни и повышает экономическое бремя здравоохранения за счет частых обращений и затрат на диагностику и лечение. В связи с этим необходим анализ факторов, связанных с развитием ЛИГБ, для ее профилактики.

Цель работы — провести анализ данных о факторах, ассоциированных с развитием ЛИГБ, представленных в современной научной литературе.

Материалы и методы

Материалы и методы. Поиск информации осуществлялся в следующих базах данных: «КиберЛенинка», eLibrary.ru, PubMed, Scopus и Web of Science (на русском и английском языках). Используемые ключевые слова: «лекарственно-индуцированная головная боль»; «абузусная головная боль»; «факторы риска ЛИГБ»; medication overuse headache; medication overuse; МОН risk factors. Оценка публикаций проводилась за период с 2006 по 2025 г.

Результаты и обсуждение

Результаты и обсуждение. Известными на момент публикации факторами, ассоциированными с развитием ЛИГБ, являются: женский пол; возраст 30–50 лет; отсутствие высшего образования и низкое социально-экономическое положение; семейный статус «разведен (-а)»; наличие мигрени как исходного вида головной боли; предшествующая частота головной боли 7–14 дней в месяц; кожная аллодиния; семейный анамнез ЛИГБ и (или) злоупотребления психоактивными веществами; боли другой локализации; метаболический синдром; низкий уровень физической активности; кишечный дисбиоз; наличие зависимости; сопутствующие тревога и депрессия; когнитивные нарушения.

Заключение

Заключение. Для профилактики развития ЛИГБ необходимо учитывать факторы, ассоциированные с развитием этого заболевания, описанные в литературном обзоре.

Introduction

Introduction. In most countries, the prevalence of medication overuse headache (MOH) is 1–2 %, but in Russia, its prevalence is significantly higher — 7.6 %. MOH causes social maladaptation of patients, reduces the quality of life and increases the economic burden of healthcare due to frequent visits and the cost of diagnosis and treatment. It is necessary to analyse the factors associated with the development of MOH to prevent its development.

Objective is to provide up-to-date data on the factors associated with the development of MOH based on a literature review.

Materials and methods

Materials and methods. The information was searched in the following databases: CyberLeninka, eLibrary.ru, PubMed, Scopus, Web of Science (in Russian and English). Keywords used: medication overuse headache; medication overuse; MOH risk factors. The evaluation of publications was carried out for the period from 2006 to 2025.

Results and discussion

Results and discussion. At the time of publication, the factors known to be associated with the development of MOH included: female gender; age 30–50 years; absence of high education and low socio-economic status; marital status «divorced»; the presence of migraine; the previous headache frequency 7–14 days per month; skin allodynia; family history of MOH and (or) substance use disorder; the presence of pain of other localization; metabolic syndrome; low level of physical activity; intestinal dysbiosis; the presence of dependence; anxiety, depression or other psychiatric diseases; cognitive impairments.

Conclusion

Conclusion. In the prevention of medication-overuse headache, it is necessary to consider factors associated with its development, as described in this review.

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The authors declare that there are no conflicts of interest present.