urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.25.1.53CMLBCSurmj-2089Research ArticleОригинальные статьи | Original articlesOriginal articlesЭффективность воздействия йодстевиозида на уровень цитокинов в сыворотке крови при йододефицитном гипотиреозеEffect of Iodostevioside on Serum Cytokine Levels in Iodine-Deficient Hypothyroidismhttps://orcid.org/0009-0004-2354-7057ШаймардановА. Т.ShajmardanovA. T.

Анвар Тимурович Шаймарданов — аспирант кафедры патологической физиологии 

Уфа 

Anvar T. Shajmardanov — Postgraduate Student of the Department of Pathological Physiology 

Ufa 

shaym.2016@mail.ruБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian Federation20262702202625153–63Copyright © Шаймарданов А.Т., 20262026Шаймарданов А.Т.Shajmardanov A.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/2089

Цель исследования — оценить влияние нового йодгликозидного комплекса (йодстевиозида) на уровень про- и противовоспалительных цитокинов в сыворотке крови крыс с экспериментальным йододефицитным гипотиреозом.

Материалы и методы

Материалы и методы. В сыворотке крови трех групп (опытной, контрольной и основной) крыс с йододефицитным гипотиреозом, индуцированным тиамазолом, и интактных животных исследовались тиреоидный статус и соотношение про- и противовоспалительных цитокинов. Интактные и опытные животные выводились из эксперимента на 22-е сутки. Оставшиеся животные еще 30 дней содержались в условиях вивария: контрольная группа на обычном рационе; основная дополнительно получала новый йодгликозидный комплекс на основе стевиозида.

Результаты

Результаты. Тиамазол вызывал у крыс развитие гипотиреоза со статистически значимым снижением в сыворотке крови содержания тиреоидных гормонов и повышением тиротропина в 2 раза. Уровень провоспалительных цитокинов у гипотиреозных животных достоверно увеличивался; интерлейкина 4 — не изменялся; интерлейкина 10 — снижался, приводя к превалированию провоспалительных цитокинов. В течение 30 дней восстановительного периода в контрольной группе крыс отмечалась положительная динамика исследованных показателей. Введение животным основной группы на протяжении 30 дней реабилитации йодстевиозида привело к нормализации содержания тиреоидных гормонов, а также восстановлению баланса цитокинов. Соотношение суммы провоспалительных цитокинов к противовоспалительным (цитокиновый баланс) у интактных крыс соответствовало 2,261; опытных — 3,229; контрольных — 2,982; основной группы — 2,266. 

This study aimed to evaluate the effect of a new iodoglycoside complex — iodostevioside — on the level of proand anti-inflammatory cytokines in the blood serum of rats with experimental iodine deficiency hypothyroidism.

Materials and methods. Thyroid status and the ratio of pro- and anti-inflammatory cytokines were studied in the blood serum of three groups (experimental, control and main) of rats with iodine-deficiency hypothyroidism induced by thiamazole and intact ones. Intact and experimental animals were sacrificed on day 22. The remaining animals were kept in a vivarium for another 30 days: the control group received a standard diet, while the experimental group additionally received a new iodoglycoside complex based on stevioside.

Results indicated that thiamazole induced hypothyroidism in rats, with a statistically significant decrease in serum thyroid hormone levels and a twofold increase in thyrotropin. Levels of proinflammatory cytokines in hypothyroid animals increased statistically significantly; interleukin 4 remained unchanged; interleukin 10 decreased, leading to a predominance of proinflammatory cytokines. During the 30-day recovery period, positive dynamics in the studied parameters were observed in the control group of rats. Administration of iodine stevioside to the animals in the main group during the 30-day rehabilitation period led to normalization of thyroid hormone levels and restoration of cytokine balance. The ratio of the sum of proinflammatory cytokines to anti-inflammatory ones (cytokine balance) in intact rats was 2.261; in experimental rats — 3.229; in control rats — 2.982; in rats of the main group — 2.266. 

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The authors declare that there are no conflicts of interest present.