urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.25.2.7CFPDZIurmj-2153Research ArticleОригинальные статьи | Original articlesOriginal articlesСодержание и свойства соединений магния в некоторых биологически активных добавкахContent and Properties of Magnesium Compounds in Some Dietary Supplementshttps://orcid.org/0000-0002-9464-6560КуприяноваИ. Н.KupriyanovaI. N.

Инесса Николаевна Куприянова — кандидат медицинских наук, доцент кафедры факультетской терапии, аллергологии и иммунологии, институт клинической медицины

Екатеринбург

Inessa N. Kupriyanova — Candidate of Sciences (Medicine), Associate Professor of the Department of Faculty Therapy, Allergology, and Immunology, Institute of Clinical Medicine

Ekaterinburg

237380@mail.ruhttps://orcid.org/0000-0002-0198-3016БелоконоваН. А.BelokonovaN. A.

Надежда Анатольевна Белоконова — доктор технических наук, кандидат химических наук, профессор, заведующий кафедрой общей химии, институт клинической фармакологии и фармации

Екатеринбург

Nadezhda A. Belokonova — Doctor of Sciences (Enginery), Candidate of Sciences (Chemistry), Professor, Head of the Department of General Chemistry, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

89221503087@mail.ruhttps://orcid.org/0000-0002-8271-7253МедведеваО. М.MedvedevaO. M.

Ольга Михайловна Медведева — кандидат химических наук, доцент кафедры общей химии, институт клинической фармакологии и фармации

Екатеринбург

Olga M. Medvedeva  — Candidate of Sciences (Chemistry), Associate Professor of the Department of Gen‑ eral Chemistry, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

olgapeter48@gmail.comhttps://orcid.org/0000-0002-1317-3109МельниковаО. А.MelnikovaO. A.

Ольга Александровна Мельникова — доктор фармацевтических наук, профессор, профессор кафе‑ дры фармации, институт клинической фармакологии и фармации

Екатеринбург

Olga A. Melnikova — Doctor of Sciences (Pharmaceutics), Professor, Professor of the Department of Pharmacy, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

newfarmacia@mail.ruhttps://orcid.org/0000-0002-1363-5262ТихомироваЕ. И.TikhomirovaE. I.

Елена Игоревна Тихомирова — кандидат химических наук, доцент кафедры общей химии, институт клинической фармакологии и фармации

Екатеринбург

Elena I. Tikhomirova — Candidate of Sciences (Chemistry), Associate Professor of the Department of Gener‑ al Chemistry, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

helen_2504@mail.ruhttps://orcid.org/0009-0002-4164-2934КасаткинаИ. Г.KasatkinaI. G.

Ирина Геннадьевна Касаткина — ассистент кафедры общей химии, институт клинической фармакологии и фармации

Екатеринбург

Irina G. Kasatkina — Assistant of the Department of General Chemistry, Institute of Clinical Pharmacology and Pharmacy

Ekaterinburg

irina_kasatkina_79@mail.ruУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation2026260420262527–19Copyright © Куприянова И.Н., Белоконова Н.А., Медведева О.М., Мельникова О.А., Тихомирова Е.И., Касаткина И.Г., 20262026Куприянова И.Н., Белоконова Н.А., Медведева О.М., Мельникова О.А., Тихомирова Е.И., Касаткина И.Г.Kupriyanova I.N., Belokonova N.A., Medvedeva O.M., Melnikova O.A., Tikhomirova E.I., Kasatkina I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/2153Введение

Введение. Актуальной проблемой здравоохранения является дефицит магния. Для его профилактики рекомендовано применение биологически активных добавок (БАД), содержащих комплексные соединения магния.

Цель — изучить химический состав БАД, оценить содержание магния с учетом растворимости при разных значениях водородного показателя (pH) и липофильность соединений магния для прогнозирования их биодоступности.

Материалы и методы

Материалы и методы. Исследовано 5 образцов БАД солей магния. Применены методы потенциометрии и трилонометрии при растворении в воде и разбавленной соляной кислоте; измерено перераспределение соединений магния в органический растворитель (липофильность).

Результаты

Результаты. Исследуемые образцы показали лучшую растворимость магния в кислой среде, чем воде, что соответствует физиологическим условиям желудочного сока. Содержание магния в одной таблетке или капсуле было меньше указанного на упаковке за исключением образца 5. Изучение липофильных свойств комплексных соединений и солей магния по распределению в бутанол показало, что в кислой среде образуется от 5 % до 58 % биодоступных липофильных соединений. Содержание в составе образца 4 аморфного оксида кремния в качестве антислеживающего агента повышает величину рН водного раствора до 9,9, что имеет практическую целесообразность для назначения этих БАД пациентам с различными рН-зависимыми патологиями.

Заключение

Заключение. Полученные лабораторным путем показатели (растворимость, уровень рН и липофильность) позволяют предсказать потенциальную биодоступность солей магния из БАД при приеме внутрь пациентами.

Introduction

Introduction. Magnesium deficiency is a pressing public health problem. To prevent it, the use of biologically active supplements containing magnesium complexes is recommended.

Objective is to study the chemical composition of dietary supplements, evaluate the magnesium content taking into account the solubility at different pH values and the lipophilicity of magnesium compounds to predict their bioavailability.

Materials and methods

Materials and methods. Five types of magnesium dietary supplements were studied. Bioavailability was assessed by potentiometry and trilometry when dissolved in water and dilute hydrochloric acid, and the lipophilicity was additionally assessed.

Results

Results. The samples showed significantly better solubility of magnesium in an acidic environment than in water. The Mg content in one tablet or capsule was less than indicated on the package, with the exception of sample 5. The study of the lipophilic properties of complex compounds and salts of Mg by distribution in butanol showed that from 5 % to 58 % of lipophilic compounds are formed in an acidic environment. The content of amorphous silicon dioxide in sample 4 as an anti-caking agent increases the pH of the aqueous solution to 9.9, which has practical relevance for prescribing these dietary supplements to patients with various pH-dependent pathologies.

Conclusion

Conclusion. Laboratory-obtained parameters (solubility, pH level and lipophilicity) allow us to predict the potential bioavailability of magnesium salts from dietary supplements when taken orally by patients.

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The authors declare that there are no conflicts of interest present.