urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.52420/umj.25.3.107OIGGHVurmj-2234Research ArticleЛитературные обзоры | Literature reviewsLiterature reviewsСовременные представления о роли адипокинов в патогенезе ишемической болезни сердцаCurrent Understanding of the Role of Adipokines in the Pathogenesis of Coronary Heart Diseasehttps://orcid.org/0000-0001-6487-9083ОсиковМ. В.OsikovM. V.

Михаил Владимирович Осиков — доктор медицинских наук, профессор, профессор Российской академии наук, заведующий кафедрой патофизиологии, Южно-Уральский государственный медицинский университет; начальник отдела научной работы, Челябинская областная клиническая больница 

Челябинск 

Mikhail V. Osikov — Doctor of Sciences (Medicine), Professor, Professor of the Russian Academy of Sciences, Head of the Department of Pathophysiology, South Ural State Medical University; Head of the Research Department, Chelyabinsk Regional Clinical Hospital 

Chelyabinsk 

prof.osikov@yandex.ruhttps://orcid.org/0000-0003-1243-0211ЭфросЛ. А.EfrosL. A.

Лидия Александровна Эфрос — доктор медицинский наук, доцент, профессор кафедры госпитальной терапии 

Челябинск 

Lydia A. Efros — Doctor of Sciences (Medicine), Associate Professor, Professor of the Department of Hospital Therapy  

Chelyabinsk 

LLA1905@mail.ruhttps://orcid.org/0000-0002-0421-2751ЧерепенинС. М.CherepeninS. M.

Сергей Михайлович Черепенин — старший лаборант кафедры патофизиологии, Южно-Уральский государственный медицинский университет; заведующий отделением кардиологии № 1, Челябинская областная клиническая больница 

Челябинск 

Sergey M. Cherepenin — Senior Laboratory Technician of the Department of Pathophysiology, South Ural State Medical University; Head of the Department of Cardiology No. 1, Chelyabinsk Regional Clinical Hospital

Chelyabinsk 

doctorche74@mail.ruhttps://orcid.org/0009-0006-2724-3813ТрушинИ. В.TrushinI. V.

Илья Владимирович Трушин — старший лаборант кафедры патофизиологии, Южно-Уральский государственный медицинский университет; врач-рентгенолог рентгеновского отделения № 2, Челябинская областная клиническая больница 

Челябинск 

Ilya V. Trushin — Senior Laboratory Technician of the Department of Pathophysiology, South Ural State Medical University; Radiologist of the X‑ray Department No. 2, Chelyabinsk Regional Clinical Hospital

Chelyabinsk 

truchin_iv@mail.ruhttps://orcid.org/0000-0002-9700-3886АгеевЮ. И.AgeevYu. I.

Юрий Иванович Агеев — кандидат медицинских наук, доцент, доцент кафедры патофизиологии 

Челябинск 

Yuri I. Ageev — Candidate of Sciences (Medicine), Associate Professor, Associate Professor of the Department of Pathophysiology 

Chelyabinsk 

doctorageev@mail.ruhttps://orcid.org/0000-0003-2224-5175ФедосовА. А.FedosovA. A.

Алексей Анатольевич Федосов — кандидат медицинских наук, доцент, доцент кафедры гистологии, цитологии и эмбриологии 

Москва 

Alexey A. Fedosov — Candidate of Sciences (Medicine), Associate Professor, Associate Professor of the De‑ partment of Histology, Cytology and Embryology 

Moscow 

fedosov.76@mail.ruЮжно‑Уральский государственный медицинский университет; Челябинская областная клиническая больницаРоссияSouth Ural State Medical University; Chelyabinsk Regional Clinical HospitalRussian FederationЮжно‑Уральский государственный медицинский университетРоссияSouth Ural State Medical UniversityRussian FederationРоссийский университет дружбы народов имени Патриса ЛумумбыРоссияPatrice Lumumba Peoples’ Friendship University of RussiaRussian Federation202602072026253107–128Copyright © Осиков М.В., Эфрос Л.А., Черепенин С.М., Трушин И.В., Агеев Ю.И., Федосов А.А., 20262026Осиков М.В., Эфрос Л.А., Черепенин С.М., Трушин И.В., Агеев Ю.И., Федосов А.А.Osikov M.V., Efros L.A., Cherepenin S.M., Trushin I.V., Ageev Y.I., Fedosov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/2234Введение

Введение. Распространенность абдоминального ожирения и его ассоциация с ишемической болезнью сердца являются предпосылкой для изучения взаимосвязей на молекулярном уровне за счет секретируемых жировой тканью адипокинов.

Цель — провести критический анализ данных, представленных в доступных источниках, индексированных в базах данных (Российский индекс научного цитирования и PubMed) за период 2018–2026 гг., посвященных патогенетической взаимосвязи абдоминального ожирения и ишемической болезни сердца посредством эффектов адипокинов.

Результаты

Результаты. Широкий спектр (более 600) адипокинов может быть дифференцирован в зависимости от их участия в атерогенезе как ключевом субстрате ишемической болезни сердца на про- и антиатерогенные и адипокины с неопределенной ролью. Механизмы действия адипокинов проатерогенного влияния (лептин, хемерин, резистин, липокалин-2, IL-1β, IL-6, IL-8, IL-18, IFN-γ, TNF-α и др.) включают в себя формирование хронического воспаления с активацией синтеза провоспалительных цитокинов, С-реактивный белок, окислительного стресса, дислипидемии, опосредованных дисфункцией эндотелия, гладкомышечных клеток и внеклеточного матрикса сосудистой стенки, избыточным образованием пенистых клеток. Роль адипокинов антиатерогенного действия (адипонектин, FGF-21, програнулин и др.) реализуется за счет изменения липидного профиля плазмы, противовоспалительных, антиоксидантных свойств. Адипокины с неопределенной ролью в атерогенезе (адипсин, IL-17, оментин и др.) являются объектом пристального изучения и уточнения их роли в патогенезе ишемической болезни сердца. Представленная информация расширяет имеющиеся сведения о роли адипокинов в патогенезе ишемической болезни сердца, является предпосылкой для проведения дальнейших исследований и совершенствования диагностических, прогностических, терапевтических, профилактических синергичных стратегий у больных с ишемической болезнью сердца и абдоминальным ожирением в клинической практике, в т. ч. в контексте персонализированной биомолекулярной медицины, направленной на снижение глобального бремени атеросклероза. 

Introduction

Introduction. The prevalence of abdominal obesity and its association with coronary artery disease are prerequisites for studying the relationships at the molecular level due to adipokines secreted by adipose tissue.

Purpose is to conduct a critical analysis of the data presented in available sources indexed in the databases of the Russian Science Citation Index and PubMed for the period mainly 2018–2026, devoted to the pathogenetic relationship of abdominal obesity and coronary heart disease through the effects of adipokines.

Results

Results. A wide range (over 600) of adipokines can be differentiated depending on their involvement in atherogenesis as a key substrate of coronary heart disease into pro- and antiatherogenic and adipokines with an uncertain role. The role of antiatherogenic adipokines is realized by changing the lipid profile of plasma, anti-inflammatory, antioxidant properties. Adipokines with an uncertain role in atherogenesis are the object of close study and clarification of their role in the pathogenesis of coronary heart disease. The presented information expands the available information on the role of adipokines in the pathogenesis of coronary heart disease, and is a prerequisite for further research and improvement of diagnostic, prognostic, therapeutic, and preventive synergistic strategies in patients with coronary heart disease and abdominal obesity in clinical practice, including in the context of personalized biomolecular medicine aimed at reducing the global burden of atherosclerosis. 

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The authors declare that there are no conflicts of interest present.