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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urmj</journal-id><journal-title-group><journal-title xml:lang="ru">Уральский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Ural Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-4389</issn><publisher><publisher-name>Ural State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25694/URMJ.2018.12.16</article-id><article-id custom-type="elpub" pub-id-type="custom">urmj-371</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПСИХИАТРИЯ</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности и безопасности применения рисперидона у детей</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the efficacy and safety of risperidone in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малинина</surname><given-names>Елена Викторовна</given-names></name><name name-style="western" xml:lang="en"><surname>Malinina</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">malinina.e@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Забозлаева</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zabozlaeva</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чижова</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chizhova</surname><given-names>T. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пилявская</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pilyavskaya</surname><given-names>O. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колмогорова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolmogorova</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО ЮУГМУ Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГБУЗ ОКСПНБ № 1, г. Челябинск</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>14</day><month>04</month><year>2021</year></pub-date><volume>0</volume><issue>12</issue><fpage>27</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Малинина Е.В., Забозлаева И.В., Чижова Т.Н., Пилявская О.И., Колмогорова В.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Малинина Е.В., Забозлаева И.В., Чижова Т.Н., Пилявская О.И., Колмогорова В.В.</copyright-holder><copyright-holder xml:lang="en">Malinina E.V., Zabozlaeva I.V., Chizhova T.N., Pilyavskaya O.I., Kolmogorova V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.umjusmu.ru/jour/article/view/371">https://www.umjusmu.ru/jour/article/view/371</self-uri><abstract><p>В современной детской психиатрической практике все чаще используются атипичные нейролептики, в частности рисперидон, в связи с хорошей переносимостью и эффективностью. При изучении пациентов с расстройствами шизофренического спектра в возрасте от 5 до15 лет, которые получали рисперидон, наблюдалась эффективность в лечении негативной симптоматики в 91,6% (n=11). В то же время были обнаружены побочные нейроэндокринные эффекты. так, отмечалось статистически достоверное повышение пролактина, показатели которого вышли за пределы допустимой нормы уже через 1 месяц лечения и глюкозы крови, но ее уровень не превысил допустимую норму. также у всех пациентов отмечалось увеличение массы тела и роста.</p></abstract><trans-abstract xml:lang="en"><p>In modern children's psychiatric practice, atypical antipsychotics, in particular risperidone, are increasingly being used, in connection with good tolerability and efficacy. In the study of patients with schizophrenic disorders at the age of 5 to 15 years who received risperidone, efficacy in the treatment of negative symptoms in 91.6% (n = 11) was observed. At the same time, adverse neuroendocrine effects were found. So, a statistically significant increase in prolactin was noted, the indices of which went beyond the permissible norm after 1 month of treatment and blood glucose, but its level did not exceed the permissible norm. Also, all patients had an increase in body weight and height.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>расстройства шизофренического спектра</kwd><kwd>рисперидон</kwd><kwd>побочные нейроэндокринные эффекты</kwd><kwd>пролактин</kwd><kwd>disorders of the schizophrenic spectrum</kwd><kwd>risperidone</kwd><kwd>side neuroendocrine effects</kwd><kwd>prolactin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алешкина Г.А. 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