urmjУральский медицинский журналUral Medical Journal2949-4389Ural State Medical University10.25694/URMJ.2019.03.16urmj-504Research ArticleЭНДОКРИНОЛОГИЯИнсулин и лептин: спорные и нерешенные вопросы их взаимодействия при ожиренииInsulin and leptin: disputable and unsolved questions of their interaction in obesityБеликЕкатерина ВладимировнаBelikE. V.sionina.ev@mail.ruГруздеваОльга ВикторовнаGruzdevaO. V.noemail@neicon.ruПаличеваЕлена ИвановнаPalichevaE. I.noemail@neicon.ruФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийRussian FederationФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииRussian Federation201914042021031724Copyright © Белик Е.В., Груздева О.В., Паличева Е.И., 20212021Белик Е.В., Груздева О.В., Паличева Е.И.Belik E.V., Gruzdeva O.V., Palicheva E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.umjusmu.ru/jour/article/view/504

Лептин и его рецептор широко распространены главным образом в белой жировой ткани. Концентрация лептина в сыворотке крови коррелирует с индексом массы тела, а его уровни снижаются при голодании. Инсулин, по-видимому, увеличивает матричную рнк лептина, экспрессию белка и его высвобождение адипоцитами, причем синтезированного как предварительно, так и de novo, и снижает уровни адипонектина и его рецепторов. Согласно литературным данным, хроническая гиперинсулинемия повышает уровень лептина. В этом обзоре обобщены последние знания о влиянии инсулина на синтез и секрецию лептина; представлены клеточные механизмы, контролирующие синтез и высвобождение белой жировой тканью.

Leptin and its receptor are widely distributed mainly in white adipose tissue. Serum leptin concentration correlates with body mass index, and its levels decrease with fasting. Insulin appears to increase leptin messenger RNA, protein expression and release by adipocytes, both synthesized both in advance and de novo, and reduces the levels of adiponectin and its receptors. According to the literature, chronic hyperinsulinemia increases leptin levels. This review summarizes the latest knowledge on the effect of insulin on leptin synthesis and secretion; cellular mechanisms that control the synthesis and release of white adipose tissue are presented.

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The authors declare that there are no conflicts of interest present.