Treatment of purulent pyelonephritis in combination with diabetes mellitus

Abstract

Before the clinical researches, the experimental researches to study the influence of enterosgel, polisorb MP and activated carbon on absorbation of microogranisms from test-culture were conducted. The observations invitro showed that sorbent enerosgel and activated carbon in relation to the absorption of E. Coli revealed that this sorbents adsorb E.Coli actively and polisorb MP adsorbs even faster. Study of the absorption of sugar by enerosgel, polisorb MP and activated carbon from 5% sugar solution showed that enterosgel took more than a half of glucose from the original solution during 3 hours, activated carbon and polisorb MP don’t have this level of absorption. The comparative analysis of general and biochemical blood analysis and urine of patients, who have puru-lent pyelonephritis in combination with diabetes mellitus, was conducted. The main group of 26 people, who received enterosgel in the amount of 22 grams for half an hour before meals, to relieve endotoxemia and reduction of glucose in blood, and 26 people from control group, who received traditional treatment. After all experimental researches we decided that enterosgel can be prescribed in complex treatment of se-vere forms of purulent pyelonephritis in combination with diabetes mellitus. The analysis of conducted treatment testifies that complex treatment of purulent pyelonephritis in combina-tion with diabetes mellitus by injection of enterosgel leads to the reduction of direct toxic influence on tub-ular on glomerular apparatus of kidneys with improvement of renal blood circulation due to normalization of rheological parameter of blood. The evidence is the improvement of endotoxemia and homeostasis. In this regard, it is necessary to emphasize that enterosgel normalizes glucose in blood, directly participate in regulation of sugar in blood that stimulate the reduction of diabetes complications. The data of sugar dy-namics, the improvement of glomerular function and the normalization of immunity indicators testifies this.