COVID-19 and placenta-associated pregnancy complications: is there any connection?
https://doi.org/10.52420/2071-5943-2022-21-4-78-84
Abstract
Introduction. Women during pregnancy may be particularly susceptible to SARS-CoV-2 infection as physiological changes affect the cardiovascular, respiratory and immune systems. Several studies suggest that pregnant women who have had COVID-19 are not only at high risk for developing a severe infection, they also have an increased incidence of placental-associated pregnancy complications. The objective of this literature review was to establish pathogenetic relationships between COVID-19 and placenta-associated pregnancy complications. Materials and methods. International and Russian scientometric databases Google Sholar, ResearchGate, Pubmed, and Elibrary were used to analyze the scientific literature. Results and discussion. Severe COVID-19 is closely associated with preeclampsia, preterm birth, and other adverse perinatal outcomes. Pregnant women with SARS-CoV-2 infection are at higher risk of: maternal death, intensive care unit hospitalization, preterm birth and stillbirth. However, in some cases, the increased incidence of preeclampsia observed in mothers with SARS-CoV-2 may be related to misdiagnosis and iatrogenic preterm birth, as preeclampsia and COVID-19 may have similar symptoms. COVID-19 vaccination is recommended during pregnancy in high-risk groups to prevent severe maternal morbidity and adverse pregnancy and childbirth outcomes. Conclusion. COVID-19 increases the risk of placental-associated pregnancy complications. In some cases, COVID-19 mimics the clinical picture of preeclampsia, so careful differential diagnosis is required to reduce the incidence of iatrogenic preterm labor. Vaccination in pregnant women is a preventive measure against COVID-19 infection and its severe forms and may indirectly reduce in the incidence of major obstetric syndromes.
About the Authors
E. V. Kudryavtseva
Ural State Medical university
Russian Federation
Russian Federation
Elena V. Kudryavtseva – Doctor of Medicine, Associate Professor
Ekaterinburg
S. V. Martirosyan
Ural State Medical university;
Clinical Perinatal Center
Russian Federation
Russian Federation
Sergej V. Martirosyan – MD
Ekaterinburg
S. U. Utamuradova
Clinical Perinatal Center
Russian Federation
Russian Federation
Sabina U. Utamuradova – obstetrician-gynecologist
Ekaterinburg
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For citations:
Kudryavtseva EV, Martirosyan SV, Utamuradova SU. COVID-19 and placenta-associated pregnancy complications: is there any connection? Ural Medical Journal. 2022;21(4):78-84. (In Russ.) https://doi.org/10.52420/2071-5943-2022-21-4-78-84
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