Макрофаги печени как ключевые регуляторы тканевого гомеостаза в органе
https://doi.org/10.52420/2071-5943-2023-22-6-85-93
Аннотация
Введение. В работе обосновывается представление о макрофагах как о ключевых регуляторах тканевого гомеостаза в печени, действующих посредством врождённых и адаптивных иммунных реакций, инициируемых экзогенными и/или эндогенными сигналами о повреждении или клеточном стрессе. С одной стороны, сигналы из окружающей среды определяют поляризацию и продукцию макрофагов, а, с другой, сами макрофаги воздействуют на тканевое микроокружение и функции отдельных клеток и ткани в целом.
Цель работы. На основании анализа современных данных показать, что пластичность и гетерогенность макрофагов определяет их функциональную активность как регуляторов гомеостаза в печени в норме и при повреждении.
Материалы и методы. Поиск литературы, посвящённой изучению и анализу роли макрофагов в поддержании тканевого гомеостаза в печени, проводился в базе данных биомедицинских исследований Pubmed по ключевым словам «макрофаги печени», «клетки Купфера», «поляризация макрофагов», «тканевой гомеостаз», «регенерация печени» и их сочетаниям, с глубиной поиска 10 лет. Для написания обзора было отобрано 67 статей, соответствующих вышеуказанным критериям. В случае, если материалы аналогичного содержания присутствовали в нескольких публикациях, то предпочтение отдавалось наиболее свежему источнику. Большая часть отобранных для написания обзора статей (40 из 67) опубликована в 2017-2023 годах.
Результаты и обсуждение. В статье отражены структурно-функциональные характеристики различных популяций макрофагов печени, отличающиеся по фенотипу и происхождению и функциям, что определяет их роль в гомеостазе.
Заключение. Макрофаги являются ключевыми регуляторами гомеостаза в печени за счёт их способности воспринимать множество эндогенных и экзогенных сигналов в тканях и быстро реагировать на них в направлении стабилизации тканевого микроокружения.
Ключевые слова
При поддержке: Работа выполнена в рамках государственного задания ИИФ УрО РАН (регистрационный номер темы 122020900136-4)
Об авторах
К. В. Соколова
Институт иммунологии и физиологии Уральского отделения РАН
Россия
Россия
Ксения Викторовна Соколова, кандидат биологических наук, старший научный сотрудник
лаборатория морфологии и биохимии
Екатеринбург
И. Г. Данилова
Институт иммунологии и физиологии Уральского отделения РАН
Россия
Россия
Ирина Георгиевна Данилова, доктор биологических наук, главный научный сотрудник, заведующая лабораторией
лаборатория морфологии и биохимии
Екатеринбург
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Рецензия
Для цитирования:
Соколова КВ, Данилова ИГ. Макрофаги печени как ключевые регуляторы тканевого гомеостаза в органе. Уральский медицинский журнал. 2023;22(6):85-93. https://doi.org/10.52420/2071-5943-2023-22-6-85-93
For citation:
Sokolova KV, Danilova IG. Liver macrophages as the key regulators of tissue homeostasis in organ. Ural Medical Journal. 2023;22(6):85-93. (In Russ.) https://doi.org/10.52420/2071-5943-2023-22-6-85-93
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