The Role of Endothelial Function Indicators and the Hemostasis System in the Pathogenesis of Rosacea Development
https://doi.org/10.52420/umj.24.1.50
EDN: LXMVVI
Abstract
Introduction. Rosacea is a chronic inflammatory dermatosis primarily affecting the central facial skin. The localization of lesions on visible areas significantly worsens patients’ quality of life, leading to psychosomatic disorders. Endothelial dysfunction plays a key role in the pathophysiology of rosacea, contributing to inflammation, persistent capillary dilation, and vascular hyperreactivity.
Purpose of the work — to evaluate endothelial function and hemostatic system parameters in patients with erythematotelangiectatic rosacea (ETR) and papulopustular rosacea (PPR).
Materials and methods. 60 patients (30 (50 %) — ETR; 30 (50 %) — PPR) were examined, including 44 (73.33 %) women and 16 (26.67 %) men, with a mean age of (40.24±2.25) years and an average disease duration of (3.55±1.20) years. The control group consisted of 30 healthy individuals, including 17 (56.67 %) women and 13 (43.33 %) men, aged 26–55 years (mean age (38.10±1.26) years). Vascular wall and microcirculation assessments were performed using photoplethysmography (AngioScan‑01P). Hemostasis was analyzed with a “Thrombodynamics Analyzer T‑2” (LLC “GemaKor”) simulating physiological blood coagulation conditions.
Results. Endothelial dysfunction was identified in rosacea patients, more pronounced in PPR, manifesting as increased vascular biological age and stiffness (p < 0.050). Initial clot formation rate and clot density were significantly higher in PPR patients (p = 0.031 and p = 0.014).
Discussion. Comparative analysis of photoplethysmography and thrombodynamics data confirmed endothelial dysfunction and microcirculatory disturbances in both rosacea subtypes, more pronounced in PPR, highlighting their role in disease pathogenesis.
Conclusion. ETR and PPR are associated with structural and functional vascular abnormalities, microcirculatory disturbances, hypercoagulation, and an elevated risk of thrombosis.
About the Author
E. A. PiruginaRussian Federation
Elena A. Pirugina — Postgraduate Student of the Department of Skin and Venereal Diseases
Moscow
Competing Interests:
The author declare the absence of obvious or potential conflicts of interest.
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For citations:
Pirugina EA. The Role of Endothelial Function Indicators and the Hemostasis System in the Pathogenesis of Rosacea Development. Ural Medical Journal. 2025;24(1):50–58. (In Russ.) https://doi.org/10.52420/umj.24.1.50. EDN: LXMVVI