Dentistry Status Features of Patients with Non-alcoholic Fatty Liver Disease
T. N. Kaisina,
S. N. Gromova,
E. P. Kolevatykh,
A. V. Elikov,
E. A. Leushina,
N. E. Kushkova,
O. A. Maltseva,
M. A. Titov,
D. D. Turdieva,
M. S. Cheremiskina https://doi.org/10.52420/umj.24.2.7
EDN: AFEOAS
Abstract
Relevance. Changes in the oral cavity have a close relationship with pathological processes in the liver. In the scientific articles is practically no information on the description of oral cavity in non-alcoholic fatty liver disease (NAFLD) patients.
Goal — to determine the dental status of patients with NAFLD and to identify the leading mechanisms of development of oral pathology to formulate directions of dental care.
Materials and methods. Аn assessment of the dental status of patients with NAFLD in the Clinical Hospital “RZD-Medicine” (Kirov, Russia) included an objective examination, hygienic and periodontal indices, biochemical parameters of oral fluid and microbiological examination.
Results. It was revealed high prevalence of dental caries and tooth loss: the number of extracted teeth is 2 times higher than in individuals without NAFLD; 100 % patients had lesions of the oral mucosa and inflammatory periodontal diseases. A decrease in the antioxidant activity of saliva and a predominance of periodontogenic microorganisms in the oral microbiota were noted.
Discussion. Possible linking mechanisms between dentistry pathology and NAFLD include dietary patterns, changes in the gastrointestinal microbiome, and the predominance of proinflammatory reactions in the immune response.
Conclusion. Patients with NAFLD are characterized by multiple combined lesions of hard tissues of teeth, oral mucosa, and periodontium. Unfavorable changes in the biochemical composition of oral fluid and oral microflora contribute to the development and progression of pathological processes. All patients with NAFLD need complex treatment of oral cavity pathology, including oral hygiene, treatment of dental and oral mucosa lesions, periodontal diseases, prosthetics.
About the Authors
T. N. Kaisina
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Tatyana N. Kaisina — Candidate of Sciences (Medicine), Associate Professor of the Department of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
S. N. Gromova
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Svetlana N. Gromova — Candidate of Sciences (Medicine), Associate Professor, Head of the Department of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
E. P. Kolevatykh
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ekaterina P. Kolevatykh — Candidate of Sciences (Medicine), Associate Professor, Head of the Department of Microbiology and Virusology.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
A. V. Elikov
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anton V. Elikov — Candidate of Sciences (Medicine), Associate Professor of the Department of Chemistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
E. A. Leushina
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena A. Leushina — Senior Lecturer of the Department of Internal Medicine.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
N. E. Kushkova
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nadezhda E. Kushkova — Candidate of Sciences (Medicine), Associate Professor of the Department of Pathophysiology.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
O. A. Maltseva
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga A. Maltseva — Candidate of Sciences (Medicine), Associate Professor of the Department of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
M. A. Titov
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Mikhail A. Titov — Specialist’s Degree Student of the Faculty of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
D. D. Turdieva
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Dinara D. Turdieva — Specialist’s Degree Student of the Faculty of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
M. S. Cheremiskina
Kirov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Maria S. Cheremiskina — Specialist’s Degree Student of the Faculty of Dentistry.
Kirov
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest
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For citations:
Kaisina TN, Gromova SN, Kolevatykh EP, Elikov AV, Leushina EA, Kushkova NE, Maltseva OA, Titov MA, Turdieva DD, Cheremiskina MS. Dentistry Status Features of Patients with Non-alcoholic Fatty Liver Disease. Ural Medical Journal. 2025;24(2):7–20. (In Russ.) https://doi.org/10.52420/umj.24.2.7. EDN: AFEOAS
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