Comparison of the Efficacy of Platelet-Rich Plasma and Hyaluronic Acid in the Treatment of Degenerative Knee Diseases Over 12 Months of Therapy According to the Results of the Visual Analogue Pain Scale
https://doi.org/10.52420/umj.24.2.109
EDN: MPODUS
Abstract
Introduction. The primary local treatments for knee osteoarthritis (OAKS) include hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. The visual analogue pain scale (VAS) is often used to assess their effectiveness. Ongoing debate persists regarding which method provides the most sustained efficacy in reducing pain and improving joint function, complicating therapeutic decisions.
Aim — to evaluate the efficacy of OACS treatment, as measured by VAS, 12 months after the initiation of intra-articular PRP injection compared to HA injection.
Materials and methods. We included only English-language articles with full text available that presented treatment outcomes as VAS in patients treated for OACS with HA or PRP over a 12-month period.
Results. A total of 196 articles were initially selected, with 170 remaining after removing duplicates, and 4 meeting inclusion criteria. Meta-analysis of VAS at 12 months post-therapy indicated a Hedges’ g effect size of 0.26, without statistical significance. Study heterogeneity was high (I 2 = 93.48 %). Publication bias tests found no significant bias, and Trim and Fill analysis identified no missing studies needing adjustment.
Conclusion. The study revealed no significant difference between PRP and HA in treating knee osteoarthritis over 12 months. The absence of publication bias supports the reliability of these findings.
About the Authors
A. A. Shtanova
Federal Bureau of Medical and Social Expertise
Russian Federation
Competing Interests:
Russian Federation
Aleksandra A. Shtanova — Resident.
Moscow
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest.
D. A. Stepina
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Daria A. Stepina — Specialist’s Degree Student of the Institute of Surgery.
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest.
N. I. Sivkova
Ural Federal University named after the first President of Russia B.N. Yeltsin
Russian Federation
Competing Interests:
Russian Federation
Nadezhda I. Sivkova — Candidate of Sciences (Sociology), Associate Professor of the Department of Political Studies, Ural Institute of Humanities.
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest.
A. V. Zhilyakov
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Andrey V. Zhilyakov — Doctor of Sciences (Medicine), Associate Professor of the Department of Traumatology and Orthopedics, Institute of Surgery.
Ekaterinburg
Competing Interests:
editorial board member
E. A. Volokitina
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena A. Volokitina — Doctor of Sciences (Medicine), Professor, Head of the Department of Traumatology and Orthopedics.
Ekaterinburg
Competing Interests:
editorial council member of Ural Medical Journal, and they did not participate in reviewing the material or making a decision about its publication
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Shtanova AA, Stepina DA, Sivkova NI, Zhilyakov AV, Volokitina EA. Comparison of the Efficacy of Platelet-Rich Plasma and Hyaluronic Acid in the Treatment of Degenerative Knee Diseases Over 12 Months of Therapy According to the Results of the Visual Analogue Pain Scale. Ural Medical Journal. 2025;24(2):109–128. (In Russ.) https://doi.org/10.52420/umj.24.2.109. EDN: MPODUS
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