Роль генного полиморфизма коморбидной патологии в формировании осложнений при травмах костей нижних конечностей
https://doi.org/10.52420/umj.24.6.103
EDN: FEROTO
Аннотация
Причины и виды осложнений в травматологии и ортопедии после консервативного и хирургического лечения при наличии коморбидной патологии всегда привлекают к себе внимание специалистов. Таким образом, поставлена цель – проанализировать и систематизировать данные современной литературы о влиянии полиморфизма генов и сопутствующей патологии на развитие осложнений при лечении травм костей нижних конечностей. В ходе обзора определено, что осложнения в травматологии обусловлены как методами лечения, так и наличием у пациентов коморбидных состояний. Установлено, что полиморфизм определенных генов может оказывать влияние на процесс заживления переломов и общее течение посттравматического периода. В работе выделены гены, ассоциированные с нарушениями соединительной ткани, в т. ч. Коллагенопатиями и ревматическими заболеваниями, такие как HLA-DR4, HLA-DRB1, COL1A1 и COL1A2. Также рассмотрены генетические маркеры, связанные с риском развития сахарного диабета 1-го типа (SOD2, GAD1), артериальной гипертензии (GRK, PLCG2), нарушений метаболизма витамина D (VDR, GC, CYP27B1) и тромбоэмболических осложнений (FGB). Несмотря на выявление множества генов, потенциально влияющих на возникновение осложнений, мы пришли к выводу, что в настоящее время убедительные доказательства существования закономерной генетической предрасположенности отсутствуют, что требует дальнейших глубоких исследований в этом направлении.
Ключевые слова
Об авторах
В. В. Савгачев
Ярославский государственный медицинский университет
Россия
Конфликт интересов:
Россия
Виталий Владимирович Савгачев – кандидат медицинских наук, доцент кафедры травматологии и ортопедии
Ярославль
Конфликт интересов:
Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.
Л. Б. Шубин
Ярославский государственный медицинский университет
Россия
Конфликт интересов:
Россия
Леонид Борисович Шубин – кандидат медицинских наук, доцент кафедры общественного здоровья и здравоохранения
Ярославль
Конфликт интересов:
Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.
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Рецензия
Для цитирования:
Савгачев ВВ, Шубин ЛБ. Роль генного полиморфизма коморбидной патологии в формировании осложнений при травмах костей нижних конечностей. Уральский медицинский журнал. 2025;24(6):103–119. https://doi.org/10.52420/umj.24.6.103. EDN: FEROTO
For citation:
Savgachev VV, Shubin LB. The Role of Gene Polymorphism of Comorbid Pathology in the Formation of Complications in Lower Limb Bone Injury. Ural Medical Journal. 2025;24(6):103–119. (In Russ.) https://doi.org/10.52420/umj.24.6.103. EDN: FEROTO
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