Effect of Iodostevioside on Serum Cytokine Levels in Iodine-Deficient Hypothyroidism
https://doi.org/10.52420/umj.25.1.53
EDN: CMLBCS
Abstract
This study aimed to evaluate the effect of a new iodoglycoside complex — iodostevioside — on the level of proand anti-inflammatory cytokines in the blood serum of rats with experimental iodine deficiency hypothyroidism.
Materials and methods. Thyroid status and the ratio of pro- and anti-inflammatory cytokines were studied in the blood serum of three groups (experimental, control and main) of rats with iodine-deficiency hypothyroidism induced by thiamazole and intact ones. Intact and experimental animals were sacrificed on day 22. The remaining animals were kept in a vivarium for another 30 days: the control group received a standard diet, while the experimental group additionally received a new iodoglycoside complex based on stevioside.
Results indicated that thiamazole induced hypothyroidism in rats, with a statistically significant decrease in serum thyroid hormone levels and a twofold increase in thyrotropin. Levels of proinflammatory cytokines in hypothyroid animals increased statistically significantly; interleukin 4 remained unchanged; interleukin 10 decreased, leading to a predominance of proinflammatory cytokines. During the 30-day recovery period, positive dynamics in the studied parameters were observed in the control group of rats. Administration of iodine stevioside to the animals in the main group during the 30-day rehabilitation period led to normalization of thyroid hormone levels and restoration of cytokine balance. The ratio of the sum of proinflammatory cytokines to anti-inflammatory ones (cytokine balance) in intact rats was 2.261; in experimental rats — 3.229; in control rats — 2.982; in rats of the main group — 2.266.
About the Author
A. T. Shajmardanov
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anvar T. Shajmardanov — Postgraduate Student of the Department of Pathological Physiology
Ufa
Competing Interests:
The author declares the absence of obvious or potential conflict of interest.
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For citations:
Shajmardanov AT. Effect of Iodostevioside on Serum Cytokine Levels in Iodine-Deficient Hypothyroidism. Ural Medical Journal. 2026;25(1):53–63. (In Russ.) https://doi.org/10.52420/umj.25.1.53. EDN: CMLBCS
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