The Use of Photodynamic Therapy with the Photosensitizer Radachlorin at the Stage of Surgical Treatment in the Complex Therapy of Patients with Nephroblastoma
https://doi.org/10.52420/umj.25.3.7
EDN: DMHWIH
Abstract
Introduction. Malignant neoplasms in children belong to the category of socially significant pathology. Tumor progression results from local recurrence, the substrate of which is the presence of residual tumor tissue in the resection area, which requires a high level of surgical ablastics. Application of additional intervention on residual tumor tissue by means of new surgical technologies results in an increased radicalism of surgical treatment of patients with retroperitoneal tumors.
The purpose of the study is to evaluate the effectiveness of the developed technique of intraoperative photodynamic therapy (PDT) at the stage of surgical treatment of children with nephroblastoma.
Materials and methods. The study group included 66 patients with nephroblastoma, 35 boys and 31 girls. Patients in the control group (n = 35) underwent surgical treatment in combination with chemotherapy and radiation therapy according to the SIOP protocol. Patients in the main group (n = 31) received the SIOP protocol therapy in combination with PDT. A combination of surgical treatment with intraoperative PDT was used to increase the radicality of surgical intervention and reduce the local recurrence rate.
Results. In the group of patients who received PDT in addition to the surgical treatment, the death rate during the 5-year follow-up period was lower, and the survival rate, respectively, was higher — 90.3 % versus 71.4 % (p = 0.050).
Conclusion. The proposed technique of intraoperative PDT within the complex treatment of retroperitoneal tumors results in better outcomes, significantly increasing survival rate in patients with retroperitoneal tumors.
About the Authors
N. M. Rostovtsev
Chelyabinsk Regional Children’s Clinical Hospital; South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nikolay M. Rostovtsev — Candidate of Sciences (Medicine), Deputy Chief Physician for Surgery, Chelyabinsk Regional Children’s Clinical Hospital; Associate Professor of the Department of General and Pediatric Surgery, South Ural State Medical University
Chelyabinsk
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
V. G. Polyakov
N. N. Blokhin National Medical Research Center of Oncology
Russian Federation
Competing Interests:
Russian Federation
Vladimir G. Polyakov — Doctor of Sciences (Medicine), Professor, Full Member (Academician) of the Rus‑ sian Academy of Sciences, Advisor to the Director of the Research Institute of Children’s Oncology and Hematology
Moscow
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
N. E. Kuzmina
Chelyabinsk Regional Children’s Clinical Hospital; South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Natalya E. Kuzmina — Candidate of Sciences (Medicine), Radiologist, Chelyabinsk Regional Children’s Clinical Hospital; Assistant of the Department of Oncology, Radiation Diagnostics and Radiation Therapy, South Ural State Medical University
Chelyabinsk
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
E. A. Neizvestnykh
Chelyabinsk Regional Children’s Clinical Hospital; South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena A. Neizvestnykh — Candidate of Sciences (Medicine), Associate Professor of the Department of Gen‑ eral and Pediatric Surgery
Chelyabinsk
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
A. V. Kuzmina
South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anastasiya V. Kuzmina — Specialist’s Degree Student of the Faculty of Dentistry
Chelyabinsk
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
M. A. Minko
South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Maksim A. Minko — Specialist’s Degree Student of the Faculty of Dentistry
Chelyabinsk
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest.
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Review
For citations:
Rostovtsev NM, Polyakov VG, Kuzmina NE, Neizvestnykh EA, Kuzmina AV, Minko MA. The Use of Photodynamic Therapy with the Photosensitizer Radachlorin at the Stage of Surgical Treatment in the Complex Therapy of Patients with Nephroblastoma. Ural Medical Journal. 2026;25(3):7–22. (In Russ.) https://doi.org/10.52420/umj.25.3.7. EDN: DMHWIH
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