Features of the structure of the cervix pathology in pregnant women

Abstract

The aim of study was to determine the frequency and structure of cervical pathology and its relationship with the vaginal microbiota in 113 pregnant women in period from 22 to 36 weeks. Microscopy of vaginal smears, cytological examination of the cervical epithelium, determination of the microbial mass of vaginal secretion using test system "Femoflor-17" and detection of human papillomavirus DNA (HPV) in real time was conducted. Statistical processing was performed with calculation of median, mean, standard deviation, confidence interval and Pearson correlation. HPV type 16 was found in 23.8%+4.2% (95% CI: 16.8-30.8%), other high-oncogenic types of HPV in 39.8%+5% (95% CI: 30.8-48.8%) of patients, while HPV type 18 was absent in all examined women. In 48 (55%) women the titer of microbial flora exceeded 104. Atopobium vaginae was detected in 43.7%+3.2% (95% CI: 39.7-47.7%) of pregnant women. According to the results of сytology, the inflammatory was found 27: 56,2%%+2,3% (95% DI: 51.9-60.4%) of pregnant women. Inclusion cytological smears type ASCUS was in 11: 9,7%+2,9% (95% CI: 4.7-14.7%) of women, which correlated with the detection of a combination of anaerobic and aerobic flora (r=0.76).