Preview

Ural Medical Journal

Advanced search

Assessing herd immunity influenza virus among residents of Yekaterinburg and Sverdlovsk oblast during epidemic periods of 2015-17

https://doi.org/10.25694/URMJ.2018.03.024

Abstract

Thе aim of this research was acomparative assessment of the herd immunity to epidemic and seasonal influenza virus strains in the epidemic periods of 2015-2016 and 2016-2017 in compliance with the results of a sampling research of the donated blood sera in Yekaterinburg and Sverdlovsk Oblast, the Russian Federation. Hemagglutination inhibition assay test was used to assess 817 samples for antibodies to A/ California/07/09(HlNlpdm09), A/HongKong/4801/14(H3N2) and В/Phuket/3073/13 influenza viruses. Index >1:40was considered a positive antibody titre. In the pre-epidemic period of 2015, the proportion of serapositive to A/California/07/09(HlNlpdm09) virus was 36.4%. In the pre-epidemic period of 2017, this proportion for A/Hong Kong/4801/14(H3N2) virus was 38,0%, in 2017 this proportion for A/California/07/09(HlNlpdm09) virus was 58,7%. The epidemic increases in the incidence caused by the corresponding current influenza virus serotypes in these years imply that prior to every epidemic season the herd immunity of the population was insufficient for the prevention of epidemics.

About the Authors

A. V. Alimov
ФБУН «Екатеринбургский НИИ вирусных инфекций» Роспотребнадзора
Russian Federation


A. Yu. Markaryan
ФБУН Екатеринбургский НИИ вирусных инфекций» Роспотребнадзора
Russian Federation


I. B. Vyalykh
ФБУН «Екатеринбургский НИИ вирусных инфекций» Роспотребнадзора
Russian Federation


I. A. Malchikov
ФБУН «Екатеринбургский НИИ вирусных инфекций» Роспотребнадзора
Russian Federation


Yu. V. Grigorieva
ФГБОУ ВО Уральский Государственный медицинский университет Минздрава России
Russian Federation


E. N. Burnatova
Институт иммунологии и физиологии
Russian Federation


I. P. Malchikova
ГБУЗ СО «ОСПК»
Russian Federation


References

1. Ильина Т.Н. Оценка эпидемиологической эффективности гриппозной инактивированной полимер-субъединичной вакцины при иммунизации школьников. Вопросы современной педиатрии. 2009; 8 (5): 48-52.

2. Методические указания «Методы определения показателей качества иммунобиологических препаратов для профилактики и диагностики гриппа» МУ 3.3.2.1758-03 утверждены 28 сентября 2003 г.

3. Методические указания «Профилактика инфекционных болезней» МУ 3.1.2943-11 утверждены 15 июля 2011 г.

4. Brugh M Jr. A simple method for recording and analyzing serological data. Avian Dis. 1978 Apr-Jun;22(2)-Р. 362-5.

5. Delangue J., Salez N., Ninove L., Kieffer A., Zandotti C., Seston M., Lina B., Nougairede A., Charrel R., Flahault A., de Lamballerie X. Serological study of the 2009 pandemic due to influenza A H1N1 in the metropolitan French population . Clin Microbiol Infect. 2012 Feb;18(2):177-83.

6. Koopmans M., de Bruin E., Godeke G.J., Friesema I., van Gageldonk R., Schipper M., Meijer A., van Binnendijk R., Rimmelzwaan G.F., de Jong M.D., Buisman A, van Beek J, van de Vijver D, Reimerink. Profiling of humoral immune responses to influenza viruses by using protein microarrayJ. Clin Microbiol Infect. 2012 Aug;18(8):797-807.

7. Metcalf C.J.E., Ferrari M., Graham A.L., Grenfell B.T. Understanding herd immunity. Trends Immunol., 2015; 36 (12): 753-755. doi: 10.1016/j.it.2015.10.004

8. World Health Organization surveillance network: manual for the laboratory diagnoses and virological surveillance of influenza. Geneva, WHO, 2011, - p.59-62.


Review

For citations:


Alimov AV, Markaryan AY, Vyalykh IB, Malchikov IA, Grigorieva YV, Burnatova EN, Malchikova IP. Assessing herd immunity influenza virus among residents of Yekaterinburg and Sverdlovsk oblast during epidemic periods of 2015-17. Ural Medical Journal. 2018;(3):115-117. (In Russ.) https://doi.org/10.25694/URMJ.2018.03.024

Views: 101


ISSN 2071-5943 (Print)
ISSN 2949-4389 (Online)