Features of obstetric-gynecologic history of patients with different molecular-genetic subtypes of breast cancer

Abstract

Analysis was performed of obstetric and gynecologic history of 262 primary breast cancer patients referred for surgery to regional oncological center in January - December 2013 year. All patients were divided into 6 groups according to cancer molecular-biological subtype: 1) triple negative with basal phenotype, 2) triple negative without basal phenotype, 3) luminal B Her2neu+( positive), 4) luminal А, 5) luminal B Her2neu- negative, 6) non luminal Her2neu+. Results. Patients with more aggressive and prognostically worse triple negative and luminal B Her2neu positive subtypes of cancer had more abortions and miscarriages. Proportion of women with 3 and more pregnancies in group of triple negative cancer was higher compared with luminal. Amount of deliveries was also higher for patients with triple negative cancer compared to those with favourable luminal subtypes.