10-year results of the breast cancer screening program in Khanty-Mansiysk state region-Ugra

Abstract

The main aim of this study is to evaluate the quality of the Breast Cancer Screening Program performed in the Khanty-Mansiysk State Region - Ugra. The screening covers women over 40 years old. The screening interval is 2 years, with two-view mammography and single reading as the standard. During 2007-16 within the Program, 451139 women were screened in the region. The screening coverage rate (2015-16 round) was 41%. 9,3% of screened were referred for further assessment. The screen detection rate was 3.5 per 1000 screened. The test sensitivity for the first round was estimated as 80%. A 42% increase in newly diagnosed stage T1N0M0 breast cancer and 21% reduction in breast cancer detected with tumour size over 20 mm were observed compared to expected absolute number from the 2002-06 trend. Mammographic screening has contributed to a significant reduction in breast cancer mortality - 23,7% reduction using absolute mortality results. Continuous 10-year mammographic screening in Ugra has contributed to a significant improvement in the early disease diagnosis and, as a result, a reduction in absolute mortality rate from breast cancer were observed. In clinical terms, since the findings to date suggest a benefit of the screening, the main aim should be to improve coverage of the population with screening.