Mechanisms of Formation and Progression of Endothelial Dysfunction in Women with Preeclampsia: The Role of Hypertension and Postoperative Pain

Introduction. An increase in the level of placental factors in pregnant women with preeclampsia is the cause of hypertension and endothelial dysfunction. These phenomena often progress in the early postoperative period of cesarean section. Severe complications and an increased risk of developing diseases of the cardiovascular system are possible.

The aim — to analyze the available literature on the study of the effect of postoperative pain on the progression of endothelial dysfunction and hypertension in women with preeclampsia after cesarean section.

Materials and methods. A search was conducted for publications from the PubMed/MEDLINE and eLibrary.ru databases over the past 5 years

Results and discussion. In pregnant women with preeclampsia and patients with postoperative pain syndrome, the mechanisms of vascular endothelial damage and the development of hypertension are the same: inflammation, oxidative stress, changes in the response of immune cells, activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. The progression of endothelial dysfunction and hypertension in the early postoperative period of cesarean section in women with preeclampsia may depend on the pain syndrome.

Conclusion. Pain syndrome activates inflammation, oxidative stress and changes in the response of immune cells in the early postoperative period of cesarean section. This may be the cause of the progression of endothelial dysfunction and hypertension in women with preeclampsia. Regional analgesia can reduce these phenomena.

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