Preview

Уральский медицинский журнал

Расширенный поиск

Преэклампсия: медико-социальные риски и экономические последствия. Системный взгляд на акушерскую проблему XXI века

https://doi.org/10.52420/umj.24.6.82

EDN: HDYOVF

Аннотация

Преэклампсия – не просто акушерское осложнение, а системный кардиометаболический стресс-тест, раскрывающий скрытые риски для здоровья матери и ребенка на десятилетия вперед. Признанная одной из ведущих причин материнской и перинатальной смертности преэклампсия выходит далеко за рамки гестационного периода: она является мощным предиктором будущих заболеваний у женщины, а также фактором риска нарушений развития, метаболического синдрома и артериальной гипертензии у потомства. В настоящей работе представлен комплексный анализ факторов риска и патогенеза, клинических проявлений, современных подходов к профилактике и лечению, а также социально-экономического бремени преэклампсии для системы здравоохранения и общества. Особое внимание уделено формированию междисциплинарной модели ведения таких пациенток, включая принципы пожизненного диспансерного наблюдения. Преэклампсия требует переосмысления: от эпизодического акушерского вмешательства к стратегии долгосрочной охраны здоровья двух поколений. Это диктует необходимость тесного взаимодействия акушеров-гинекологов, кардиологов, неврологов, эндокринологов и терапевтов для формирования единой жизненной стратегии охраны здоровья женщины. Ее последствия носят системный и пролонгированный характер, что делает ее одной из ключевых проблем не только акушерства, но и здравоохранения в целом.

Об авторах

Е. С. Таскина
Читинская государственная медицинская академия; Забайкальский краевой перинатальный центр
Россия

Елизавета Сергеевна Таскина – кандидат медицинских наук, доцент кафедры офтальмологии; офтальмолог

Чита


Конфликт интересов:

Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.



В. А. Мудров
Читинская государственная медицинская академия; Забайкальский краевой перинатальный центр
Россия

Виктор Андреевич Мудров – доктор медицинских наук, доцент, профессор кафедры акушерства и гинекологии педиатрического факультета и факультета дополнительного профессионального образования; акушер-гинеколог

Чита


Конфликт интересов:

Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.



И. В. Кибалина
Читинская государственная медицинская академия
Россия

Ирина Владимировна Кибалина – доктор медицинских наук, доцент, директор научно-исследовательского института молекулярной медицины, заведующий кафедрой нормальной физиологии имени профессора Б. И. Кузника

Чита


Конфликт интересов:

Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.



Е. Н. Агафонова
Забайкальский краевой перинатальный центр
Россия

Елена Николаевна Агафонова – главный врач

Чита


Конфликт интересов:

Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.



О. А. Старицына
Забайкальский краевой перинатальный центр
Россия

Ольга Анатольевна Старицына – заведующий отделением патологии беременных

Чита


Конфликт интересов:

Авторы заявляют об отсутствии явных и потенциальных конфликтов интересов.



Список литературы

1. Martini C, Saeed Z, Simeone P, Palma S, Ricci M, Arata A, et al. Preeclampsia: Insights into pathophysiological mechanisms and preventive strategies. American Journal of Preventive Cardiology. 2025;23:101054. DOI: https://doi.org/10.1016/j.ajpc.2025.101054.

2. Chiang YT, Seow KM, Chen KH. The pathophysiological, genetic, and hormonal changes in preeclampsia: A systematic review of the molecular mechanisms. International Journal of Molecular Sciences. 2024; 25(8):4532. DOI: https://doi.org/10.3390/ijms25084532.

3. Traub A, Sharma A, Gongora MC. Hypertensive disorders of pregnancy: A literature review — pathophysiology, current management, future perspectives, and healthcare disparities. US Cardiology. 2024;18:e03. DOI: https://doi.org/10.15420/usc.2023.01.

4. Shkurenko YuV, Ibatov AD, Alieva UE. Medical and social aspects of preeclampsia. Clinical Medicine (Russian Journal). 2024;102(1):12–18. (In Russ.). DOI: https://doi.org/10.30629/0023-2149-2024-102-1-12-18.

5. Serenko KA. Clinical and economic analysis of preeclampsia prevention Current problems of health care and medical statistics. 2024;(1):1025–1047. (In Russ.). DOI: https://doi.org/10.24412/2312-2935-2024-1-1025-1047.

6. Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: Prevalence, risk factors, predictors and prognosis. Hypertension Research. 2017;40(3):213–220. DOI: https://doi.org/10.1038/hr.2016.126.

7. Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. International Journal of Gynecology & Obstetrics. 2019;146(3):390–391. DOI: https://doi.org/10.1002/ijgo.12892.

8. Zhao Y, Wang Y, Tong F, Gao Q, Li B. Epidemiology of maternal hypertensive disorders. Hypertension. 2025;82(5):e88–e101. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.124.23765.

9. Stupac VS, Petrov IV, Sokolovskaya TA, Samoylova AA, Vinogradov DA, Vinogradova VS, et al. Epidemiological monitoring of morbidity in pregnant women in the Russian Federation: Trends and medical and organizational prerequisites for adjusting prevention programs at the population level. Russian Journal of Human Reproduction. 2025;31(2):7–16. (In Russ.). DOI: https://doi.org/10.17116/repro2025310217.

10. Golubev NA, Ogryzko EV, Zalevskaya OV, Kapustina MV. Morbidity and pathological conditions of pregnant women in the Russian Federation. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(3):11–19. (In Russ.). DOI: https://doi.org/10.17116/rosakush20212103111.

11. Sidorova IS, Nikitina NA, Filippov OS, Guseva EV, Ageev MB, Kokin AA. Resolved and unresolved issues of preeclampsia based on the results of the analysis of maternal mortality over the past 10 years. Obstetrics and Gynecology. 2021;(4):64–74. (In Russ.). DOI: https://doi.org/10.18565/aig.2021.4.64-74.

12. Babazhanova SD, Lyubchich AS, Jabbarova YK. Risk factors of maternal death in preeclampsia. Fundamental and Clinical Medicine. 2021;6(1):27–31. (In Russ.). DOI: https://doi.org/10.23946/2500-0764-2021-6-1-27-31.

13. Kornacki J, Olejniczak O, Sibiak R, Gutaj P, Wender-Ozegowska E. Pathophysiology of pre-eclampsia-two theories of the development of the disease. International Journal of Molecular Sciences. 2023;25(1):307. DOI: https://doi.org/10.3390/ijms25010307.

14. Ren Z, Gao Y, Gao Y, Liang G, Chen Q, Jiang S, et al. Distinct placental molecular processes associated with early-onset and late-onset preeclampsia. Theranostics. 2021;11(10):5028–5044. DOI: https://doi.org/10.7150/thno.56141.

15. Bune GT. Pregnancy-induced hypertensive disorders predictors among pregnant and delivery mothers receiving care in public health institutions in Sidama, Ethiopia: A multicenter case control study. BMC Pregnancy Childbirth. 2024;24(1):683. DOI: https://doi.org/10.1186/s12884-024-06886-1.

16. Bartsch E, Medcalf KE, Park AL, Ray JG; High Risk of Pre-eclampsia Identification Group. Clinical risk factors for pre-eclampsia determined in early pregnancy: Systematic review and meta-analysis of large cohort studies. BMJ. 2016;353:i1753. DOI: https://doi.org/10.1136/bmj.i1753.

17. Poornima IG, Indaram M, Ross JD, Agarwala A, Wild RA. Hyperlipidemia and risk for preclampsia. Journal of Clinical Lipidology. 2022;16(3):253–260. DOI: https://doi.org/10.1016/j.jacl.2022.02.005.

18. Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, et al. Polygenic prediction of preeclampsia and gestational hypertension. Nature Medicine. 2023;29(6):1540–1549. DOI: https://doi.org/10.1038/s41591-023-02374-9.

19. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, et al. Gene-centric analysis of preeclampsia identifies maternal association at PLEKHG1. Hypertension. 2018;72(2):408–416. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.117.10688.

20. Tyrmi JS, Kaartokallio T, Lokki AI, Jaaskelainen T, Kortelainen E, Ruotsalainen S, et al. Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy. JAMA Cardiology. 2023;8(7):674–683. DOI: https://doi.org/10.1001/jamacardio.2023.1312.

21. McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, Shooter S, Hjartardottir S, et al. Variants in the fetal genome near FLT‑1 are associated with risk of preeclampsia. Nature Genetics. 2017;49(8):1255–1260. DOI: https://doi.org/10.1038/ng.3895.

22. Pankiewicz K, Szczerba E, Maciejewski T, Fijałkowska A. Non-obstetric complications in preeclampsia. Przeglad Menopauzalny = Menopause Review. 2019;18(2):99–109. DOI: https://doi.org/10.5114/pm.2019.85785.

23. Jones-Muhammad M, Warrington JP. Cerebral blood flow regulation in pregnancy, hypertension, and hypertensive disorders of pregnancy. Brain Sciences. 2019;9(9):224. DOI: https://doi.org/10.3390/brainsci9090224.

24. Orabona R, Sciatti E, Prefumo F, Vizzardi E, Bonadei I, Valcamonico A, et al. Pre-eclampsia and heart failure: A close relationship. Ultrasound in Obstetrics and Gynecology. 2018;52(3):297–301. DOI: https://doi.org/10.1002/uog.18987.

25. Vaught AJ, Kovell LC, Szymanski LM, Mayer SA, Seifert SM, Vaidya D, et al. Acute cardiac effects of severe pre-eclampsia. Journal of the American College of Cardiology. 2018;72(1):1–11. DOI: https://doi.org/10.1016/j.jacc.2018.04.048.

26. Miller EC, Vollbracht S. Neurology of preeclampsia and related disorders: An update in neuro-obstetrics. Current Pain and Headache Reports. 2021;25(6):40. DOI: https://doi.org/10.1007/s11916-021-00958‑z.

27. Yu E, Green JM, Aberle LS, Mandelbaum RS, Brueggmann D, Ouzounian JG, et al. Posterior reversible encephalopathy syndrome following eclampsia: Assessment of clinical and pregnancy characteristics. American Journal of Obstetrics and Gynecology. 2024;231(1):e19–e25. DOI: https://doi.org/10.1016/j.ajog.2024.02.298.

28. Fishel Bartal M, Sibai BM. Eclampsia in the 21st century. American Journal of Obstetrics and Gynecology. 2022;226(2 Suppl):S1237–S1253. DOI: https://doi.org/10.1016/j.ajog.2020.09.037.

29. Lee S, Kim Y, Navi BB, Abdelkhaleq R, Salazar-Marioni S, Blackburn SL, et al. Risk of intracranial hemorrhage associated with pregnancy in women with cerebral arteriovenous malformations. Journal of NeuroInterventional Surgery. 2021;13(8):707–710. DOI: https://doi.org/10.1136/neurintsurg‑2020-016838.

30. Meeks JR, Bambhroliya AB, Alex KM, Sheth SA, Savitz SI, Miller EC, et al. Association of primary intracerebral hemorrhage with pregnancy and the postpartum period. JAMA Network Open. 2020;3(4):e202769. DOI: https://doi.org/10.1001/jamanetworkopen.2020.2769.

31. Wu P, Jordan KP, Chew-Graham CA, Coutinho T, Lundberg GP, Park KE, et al. Temporal trends in pregnancy-associated stroke and its outcomes among women with hypertensive disorders of pregnancy. Journal of the American Heart Association. 2020;9(15):e016182. DOI: https://doi.org/10.1161/JAHA.120.016182.

32. Moghaddas SH, Zununi VS, Ardalan M. Preeclampsia: A close look at renal dysfunction. Biomedicine & Pharmacotherapy. 2019;109:408–416. DOI: https://doi.org/10.1016/j.biopha.2018.10.082.

33. Kumari P, Trivedi K, Banerjee S, Sharma A, Sinha T, Boipai P, et al. Study on incidence of pregnancy-related acute kidney injury and its associated risk factors and outcomes: In preponderant tribal state of India. Annals of African Medicine. 2025;24(2):304–309. DOI: https://doi.org/10.4103/aam.aam_200_24.

34. Sundaram S, Giri S. Liver diseases in the parturient. Indian Journal of Critical Care Medicine. 2021;25(Suppl 3): S248–S254. DOI: https://doi.org/10.5005/jp-journals‑10071–24027.

35. Varlas VN, Bohilțea R, Gheorghe G, Bostan G, Angelescu GA, Penes ON, et al. State of the art in hepatic dysfunction in pregnancy. Healthcare. 2021;9(11):1481. DOI: https://doi.org/10.3390/healthcare9111481.

36. Lisonkova S, Razaz N, Sabr Y, Muraca GM, Boutin A, Mayer C, et al. Maternal risk factors and adverse birth outcomes associated with HELLP syndrome: A population-based study. An International Journal of Obstetrics and Gynaecology. 2020;127(10):1189–1198. DOI: https://doi.org/10.1111/1471-0528.16225.

37. Suresh I, Tr V, Hp N. Predictors of fetal and maternal outcome in the crucible of hepatic dysfunction during pregnancy. Gastroenterology Research. 2017;10(1):21–27. DOI: https://doi.org/10.14740/gr787w.

38. Dubey S, Rani J. Hepatic rupture in preeclampsia and HELLP syndrome: A catastrophic presentation. Taiwanese Journal of Obstetrics and Gynecology. 2020;59(5):643–651. DOI: https://doi.org/10.1016/j.tjog.2020.07.003.

39. Friis T, Bergman L, Hesselman S, Lindstrom L, Junus K, Cluver C, et al. Gestational hypertension, preeclampsia, and eclampsia and future neurological disorders. JAMA Neurology. 2025;82(2):142–151. DOI: https://doi.org/10.1001/jamaneurol.2024.4426.

40. Barrett PM, McCarthy FP, Kublickiene K, Cormican S, Judge C, Evans M, et al. Adverse pregnancy outcomes and long-term maternal kidney disease: A systematic review and meta-analysis. JAMA Network Open. 2020;3(2):e1920964. DOI: https://doi.org/10.1001/jamanetworkopen.2019.20964.

41. Carey C, Mulcahy E, McCarthy FP, Jennings E, Kublickiene K, Khashan A, et al. Hypertensive disorders of pregnancy and the risk of maternal dementia: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2024;231(2):196–210. DOI: https://doi.org/10.1016/j.ajog.2024.01.013.

42. Choi ES, Jung YM, Kim D, Cho SE, Park ES, Park CW, et al. Long-term cardiovascular outcome in women with preeclampsia in Korea: A large population-based cohort study and meta-analysis. Scientific Reports. 2024;14(1):7480. DOI: https://doi.org/10.1038/s41598-024-57858-6.

43. Sukmanee J, Liabsuetrakul T. Risk of future cardiovascular diseases in different years postpartum after hypertensive disorders of pregnancy: A systematic review and meta-analysis. Medicine. 2022;101(30):e29646. DOI: https://doi.org/10.1097/MD.0000000000029646.

44. Hung SK, Lee MS, Lin HY, Chen LC, Chuang CJ, Chew CH, et al. Impact of hypertensive disorders of pregnancy on the risk of stroke stratified by subtypes and follow-up time. Stroke. 2022;53(2):338–344. DOI: https://doi.org/10.1161/STROKEAHA.121.034109.

45. Li Q, Wang H, Wang H, Deng J, Cheng Z, Fan F, et al. Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum. MedComm. 2024;5(7):e619. DOI: https://doi.org/10.1002/mco2.619.

46. Zhao G, Bhatia D, Jung F, Lipscombe L. Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: A systematic review and meta-analysis. Diabetologia. 2021;64(3):491–503. DOI: https://doi.org/10.1007/s00125-020-05343‑w.

47. Lailler G, Fosse-Edorh S, Lebreton E, Regnault N, Deneux-Tharaux C, Tsatsaris V, et al. Impact of different types of hypertensive disorders of pregnancy and their duration on incident post-partum risk of diabetes mellitus: Results from the French nationwide study CONCEPTION. Diabetes & Metabolism. 2024; 50(5):101564. DOI: https://doi.org/10.1016/j.diabet.2024.101564.

48. Dolgopolova EL, Lomova NA, Karavaeva AL, Zubkov VV, Shmakov RG. Severe preeclampsia and fetal growth retardation: Long-term prognoses for mothers and offspring. Obstetrics and Gynecology. 2020;(12):100–107. (In Russ.). DOI: https://doi.org/10.18565/aig.2020.12.100-107.

49. van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. The Journal of Maternal-Fetal & Neonatal Medicine. 2017;30(23):2789–2794. DOI: https://doi.org/10.1080/14767058.2016.1263295.

50. Lawrence ER, Beyuo TK, Kobernik EK, Moyer CA, Oppong SA. A comparative analysis of neonatal outcomes in pregnancies complicated by preeclampsia and eclampsia in Ghana. AJOG Global Reports. 2022; 2(3):100061. DOI: https://doi.org/10.1016/j.xagr.2022.100061.

51. Lin YW, Lin MH, Pai LW, Fang JW, Mou CH, Sung FC, et al. Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus. Scientific Reports. 2021;11(1):17391. DOI: https://doi.org/10.1038/s41598-021-96345-0.

52. Chen D, Gao X, Yang T, Xin X, Wang G, Wang H, et al. Independent risk factors for placental abruption: A systematic review and meta-analysis. BMC Pregnancy and Childbirth. 2025;25(1):351. DOI: https://doi.org/10.1186/s12884-025-07482-7.

53. Rocha de Moura MD, Margotto PR, Nascimento Costa K, Carvalho Garbi Novaes MR. Hypertension induced by pregnancy and neonatal outcome: Results from a retrospective cohort study in preterm under 34 weeks. PLoS One. 2021;16(8):e0255783. DOI: https://doi.org/10.1371/journal.pone.0255783.

54. Conlan N, Maher GM, Al Khalaf SY, McCarthy FP, Khashan AS. Association between hypertensive disorders of pregnancy and the risk of asthma, eczema and allergies in offspring: A systematic review and meta-analysis. Clinical and Experimental Allergy. 2021;51(1):29–38. DOI: https://doi.org/10.1111/cea.13754.

55. Zhen Lim TX, Pickering TA, Lee RH, Hauptman I, Wilson ML. Hypertensive disorders of pregnancy and occurrence of ADHD, ASD, and epilepsy in the child: A meta-analysis. Pregnancy Hypertension. 2023;33: 22–29. DOI: https://doi.org/10.1016/j.preghy.2023.06.002.

56. Frost AL, Suriano K, Aye CYL, Leeson P, Lewandowski AJ. The immediate and long-term impact of preeclampsia on offspring vascular and cardiac physiology in the preterm infant. Frontiers in Pediatrics. 2021;9:625726. DOI: https://doi.org/10.3389/fped.2021.625726.

57. Sandor B, Csiszar B, Galos G, Funke S, Kevey DK, Meggyes M, et al. The influence of early onset preeclampsia on perinatal red blood cell characteristics of neonates. International Journal of Molecular Sciences. 2023;24(10):8496. DOI: https://doi.org/10.3390/ijms24108496.

58. Wang W, Lin R, Yang L, Wang Y, Mao B, Xu X, et al. Meta-analysis of cardiovascular risk factors in offspring of preeclampsia pregnancies. Diagnostics. 2023;13(4):812. DOI: https://doi.org/10.3390/diagnostics13040812.

59. Yu H, Li W, Mao Z, Luo L, He N, Dong W, et al. Association between hypertensive disorders during pregnancy and elevated blood pressure in offspring: A systematic review and meta-analysis. The Journal of Clinical Hypertension. 2022;24(11):1397–1404. DOI: https://doi.org/10.1111/jch.14577.

60. Liu T, Gao R, Liu Y, Zhao K, Su X, Wong HC, et al. Hypertensive disorders of pregnancy and neonatal outcomes in twin vs. singleton pregnancies after assisted reproductive technology. Frontiers in Pediatrics. 2022;10:839882. DOI: https://doi.org/10.3389/fped.2022.839882.

61. Yan S, Lyu J, Liu Z, Zhou S, Ji Y, Wang H. Association of gestational hypertension and preeclampsia with offspring adiposity: A systematic review and meta-analysis. Frontiers in Endocrinology. 2022;13:906781. DOI: https://doi.org/10.3389/fendo.2022.906781.

62. Yang L, Huang C, Zhao M, Lee PMY, Zhang C, Yu Y, et al. Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: A nationwide population-based cohort study. BMC Medicine. 2023;21(1):59. DOI: https://doi.org/10.1186/s12916-023-02762-5.

63. Zhang H, Lin J, Zhao H. Impacts of maternal preeclampsia exposure on offspring neuronal development: Recent insights and interventional approaches. International Journal of Molecular Sciences. 2024;25(20):11062. DOI: https://doi.org/10.3390/ijms252011062.

64. Rätsep MT, Hickman AF, Maser B, Pudwell J, Smith GN, Brien D, et al. Impact of preeclampsia on cognitive function in the offspring. Behavioural Brain Research. 2016;302:175–181. DOI: https://doi.org/10.1016/j.bbr.2016.01.030.

65. Zhu H, You X, Jing Y, Chen Y, Jiang Y, Lin Y, et al. Maternal hypertensive disorder in pregnancy and childhood strabismus in offspring. JAMA Network Open. 2024;7(7):e2423946. DOI: https://doi.org/10.1001/jamanetworkopen.2024.23946.

66. Li M, Huang C, Yang W, Lee PMY, Liu Y, Lin R, et al. Evaluation of hypertensive disorder of pregnancy and high refractive error in offspring during childhood and adolescence. JAMA Network Open. 2023;6(4): e238694. DOI: https://doi.org/10.1001/jamanetworkopen.2023.8694.

67. Atkinson J, Simpson G, Walker SP, Tong S, Hastie R, Lindquist A. The long-term risk of cardiovascular disease among women with a history of hypertensive disorders of pregnancy: A systematic review of clinical practice guidelines. BMC Cardiovascular Disorders. 2023;23(1):443. DOI: https://doi.org/10.1186/s12872-023-03446-x.

68. Chen G, Chen Y, Shi Y, Mao Z, Lou J, Ma J. A dynamic prediction model for preeclampsia using the sFlt‑1/PLGF ratio combined with multiple factors. BMC Pregnancy Childbirth. 2024;24(1):443. DOI: https://doi.org/10.1186/s12884-024-06627-4.

69. Fogacci S, Fogacci F, Banach M, Michos ED, Hernandez AV, Lip GYH, et al.; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition. 2020;39(6):1742–1752. DOI: https://doi.org/10.1016/j.clnu.2019.08.015.

70. Attar A, Hosseinpour A, Moghadami M. The impact of antihypertensive treatment of mild to moderate hypertension during pregnancy on maternal and neonatal outcomes: An updated meta-analysis of randomized controlled trials. Clinical Cardiology. 2023;46(5):467–476. DOI: https://doi.org/10.1002/clc.24013.

71. Akhmadeev NR, Fatkullin IF, Nurmukhametova AI, Panteleeva BV. The possibilities of reducing the risk of maternal mortality in critical obstetric conditions. Obstetrics and Gynecology: News, Opinions, Training. 2024;12(Suppl):6–12. (In Russ.). DOI: https://doi.org/10.33029/2303-9698-2024-12-suppL-6-12.

72. Brusse IA, Kluivers ACM, Zambrano MD, Shetler K, Miller EC. Neuro-obstetrics: A multidisciplinary approach to care of women with neurologic disease. Handbook of Clinical Neurology. 2020;171:143–160. DOI: https://doi.org/10.1016/B978-0-444–64239-4.00007-2.

73. Li R, Tsigas EZ, Callaghan WM. Health and economic burden of preeclampsia: No time for complacency. American Journal of Obstetrics and Gynecology. 2017;217(3):235–236. DOI: https://doi.org/10.1016/j.ajog.2017.06.011.

74. Fox A, McHugh S, Browne J, Kenny LC, Fitzgerald A, Khashan AS, et al. Estimating the cost of preeclampsia in the healthcare system: Cross-sectional study using data from SCOPE Study (Screening for Pregnancy End Points). Hypertension. 2017;70(6):1243–1249. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.117.09499.

75. Stevens W, Shih T, Incerti D, Ton TGN, Lee HC, Peneva D, et al. Short-term costs of preeclampsia to the United States health care system. American Journal of Obstetrics and Gynecology. 2017;217(3):237–248.e16. DOI: https://doi.org/10.1016/j.ajog.2017.04.032.

76. Hao J, Hassen D, Hao Q, Graham J, Paglia MJ, Brown J, et al. Maternal and infant health care costs related to preeclampsia. Obstetrics & Gynecology. 2019;134(6):1227–1233. DOI: https://doi.org/10.1097/AOG.0000000000003581.

77. Tsigas EZ. The Preeclampsia Foundation: The voice and views of the patient and her family. American Journal of Obstetrics and Gynecology. 2022;226(2S):S1254–S1264.e1. DOI: https://doi.org/10.1016/j.ajog.2020.10.053.

78. Ofori Boadu WI, Anto EO, Wiafe EM, Nyantakyi M, Frimpong J, Korsah EE, et al. Prevalence and risk factors of postpartum depression among postnatal mothers with hypertensive disorders of pregnancy in a developing country. Women’s Health. 2025;21:17455057251338938. DOI: https://doi.org/10.1177/17455057251338938.

79. Ortved D, Ortved D, Hawkins TL, Johnson JA, Hyett J, Metcalfe A. Cost‐effectiveness of first‐trimester screening with early preventative use of aspirin in women at high risk of early‐onset pre‐eclampsia. Ultrasound in Obstetrics & Gynecology. 2019;53(2):239–244. DOI: https://doi.org/10.1002/uog.19076.

80. Rolnik DL, Wright D, Poon LCY, Syngelaki A, O’Gorman N, de Paco Matallana C, et al. ASPRE trial: Performance of screening for preterm pre-eclampsia. Ultrasound in Obstetrics and Gynecology. 2017;50(4):492–495. DOI: https://doi.org/10.1002/uog.18816.


Рецензия

Для цитирования:


Таскина ЕС, Мудров ВА, Кибалина ИВ, Агафонова ЕН, Старицына ОА. Преэклампсия: медико-социальные риски и экономические последствия. Системный взгляд на акушерскую проблему XXI века. Уральский медицинский журнал. 2025;24(6):82–102. https://doi.org/10.52420/umj.24.6.82. EDN: HDYOVF

For citation:


Taskina ES, Mudrov VA, Kibalina IV, Agafonova EN, Staritsyna OA. Preeclampsia: Medical and Social Risks and Economic Consequences. A Systematic View of the 21st Century Obstetric Problem. Ural Medical Journal. 2025;24(6):82–102. (In Russ.) https://doi.org/10.52420/umj.24.6.82. EDN: HDYOVF

Просмотров: 79


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution-NonCommercial 4.0 International.


ISSN 2949-4389 (Online)