Clinical and Laboratory Study of a New Immunomodulatory Mouthwash in Inflammatory Periodontal Diseases in Elderly Patients
Ju. V. Mandra,
V. V. Bazarnyi,
S. G. Maizel,
E. A. Sementsova,
S. S. Grigoriev,
T. M. Yelovikova,
M. P. Kharitonova,
A. V. Lyogkikh,
M. S. Mirzoeva,
N. M. Zhegalina,
P. M. Nersesyan,
A. A. Chagai,
A. S. Ivashov,
L. G. Polushina,
M. A. Kopenkin https://doi.org/10.52420/umj.25.2.31
EDN: NOAAOI
Abstract
Relevance. Elderly patients have a change in immune status. Manifestations of senescent immunodeficiency are present in the oral cavity, aggravate the main dental diseases. Local immunity plays a key role in the effective treatment and prevention of inflammatory diseases in the oral cavity.
Materials and methods. A new immunomodulatory mouthwash has been developed based on the “Immunokol LP”. It is created from bovine colostrum products. A clinical study of the effectiveness of a new mouthwash for inflammatory periodontal diseases in elderly patients included determining hygienic and periodontal indices before and after a course of its use. The laboratory study included an analysis of oral fluid parameters (general parameters, inflammatory reaction, local immunity, mineral metabolism).
Results. Clinical evaluation of the effectiveness of the new mouthwash showed an improvement in the hygienic condition of the oral cavity of patients, a decrease in the severity of residual inflammation in the periodontal tissues after a course of its use. Laboratory testing of oral fluid showed a mild anti-inflammatory and immunomodulatory effect of the mouthwash, an increase in calcium concentration, calcium-to-phosphorus ratio.
Conclusion. The new immunomodulatory mouthwash helps to reduce inflammation in the oral tissues and maintain remission of inflammatory periodontal diseases in elderly patients.
About the Authors
Ju. V. Mandra
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Julia V. Mandra — Doctor of Sciences (Medicine), Professor, Professor of the Department of Therapeutic Dentistry and Propaedeutics Dental Diseases, Director, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
V. V. Bazarnyi
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vladimir V. Bazarnyi — Doctor of Sciences (Medicine), Professor, Leading Researcher of the Department of the General Pathology, Central Research Laboratory, Institute of Fundamental Medicine
Ekaterinburg
Competing Interests:
Vladimir V. Bazarnyi is an editorial board member of Ural Medical Journal, and he did not participate in reviewing the material or making a decision about its publication
S. G. Maizel
Pobeda‑1 LLC
Russian Federation
Competing Interests:
Russian Federation
Sergei G. Maizel — Doctor of Sciences (Engineering), Professor, Chairman of the Board of Directors
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
E. A. Sementsova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena A. Sementsova — Candidate of Sciences (Medicine), Associate Professor, Associate Professor of the Department of Therapeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
S. S. Grigoriev
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Sergei S. Grigoriev — Doctor of Sciences (Medicine), Professor, Head of the Department of Therapeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
T. M. Yelovikova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Tatiana M. Yelovikova — Doctor of Sciences (Medicine), Professor, Professor of the Department of the Ther‑ apeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
M. P. Kharitonova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Marina P. Kharitonova — Doctor of Sciences (Medicine), Professor, Professor of the Department of the Or‑ thopedic Dentistry and General Dentistry, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
A. V. Lyogkikh
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Alexander V. Lyogkikh — Candidate of Sciences (Medicine), Associate Professor of the Department of the Therapeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
M. S. Mirzoeva
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Maria S. Mirzoeva — Candidate of Sciences (Medicine), Associate Professor of the Department of the Or‑ thopedic Dentistry and General Dentistry, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
N. M. Zhegalina
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Natalia M. Zhegalina — Candidate of Sciences (Medicine), Associate Professor, Associate Professor of the Therapeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
P. M. Nersesyan
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Petros M. Nersesyan — Candidate of Sciences (Medicine), Associate Professor of the Department of Surgi‑ cal Dentistry, Otolaryngology and Maxillofacial Surgery, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
A. A. Chagai
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Andrey A. Chagai — Candidate of Sciences (Medicine), Associate Professor of the Department of the Ther‑ apeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
A. S. Ivashov
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Alexander S. Ivashov — Candidate of Sciences (Medicine), Associate Professor of the Department of the Therapeutic Dentistry and Propaedeutics Dental Diseases, Institute of Dentistry
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
L. G. Polushina
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Larisa G. Polushina — Candidate of Sciences (Medicine), Senior Researcher of the Department of the Gen‑ eral Pathology, Central Research Laboratory, Institute of Fundamental Medicine
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
M. A. Kopenkin
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Maxim A. Kopenkin — Postgraduate Student, Junior Researcher of the Department of the General Pathol‑ ogy, Central Research Laboratory, Institute of Fundamental Medicine
Ekaterinburg
Competing Interests:
The other authors declare the absence of obvious or potential conflicts of interest
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For citations:
Mandra JV, Bazarnyi VV, Maizel SG, Sementsova EA, Grigoriev SS, Yelovikova TM, Kharitonova MP, Lyogkikh AV, Mirzoeva MS, Zhegalina NM, Nersesyan PM, Chagai AA, Ivashov AS, Polushina LG, Kopenkin MA. Clinical and Laboratory Study of a New Immunomodulatory Mouthwash in Inflammatory Periodontal Diseases in Elderly Patients. Ural Medical Journal. 2026;25(2):31–45. (In Russ.) https://doi.org/10.52420/umj.25.2.31. EDN: NOAAOI
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