Changes to vaginal microbiotes in women with pulmonary tuberculosis and long-term chemotherapy

Objective: To determine the quantitative changes in the microbiocenosis of the mucous genital tract in women with tuberculosis of the respiratory system against the background of ongoing chemotherapy. Material and methods: 54 women with tuberculosis of respiratory organs were examined at the stage of selection and within 40-150 days of chemotherapy. A standard study was carried out in the clinics of phthisiology and obstetrics and gynecology; specialized study of vaginal microbiota using the innovative test system "Femoflor" (LLC "NPO DNA - technology”, Russia) with PCR - real-time detection of the results and quantitative description of 28 conditionally pathogenic microorganisms. Statistical processing of the results was carried out using the statistical package IBM SPSS Statistics v.21 (2012). Results: After 40-150 days of chemotherapy in the vaginal microbiota, a significant decrease in Lactobacillus spp was established. Enterobacteriaceae, Streptococcus spp., Staphylococcus spp., Sneathia spp., Lachnobacterium spp., Mobiluncus spp., Megasphaera spp., Peptostreptococcus spp. and an increase in Gardnerella vaginalis, Prevotella, Porphyromonas, Candida spp. Conclusion: 1. Women of reproductive age, patients with newly diagnosed respiratory tuberculosis, who are receiving long-term courses of chemotherapy, represent a risk group for the development of vaginal dysbiosis.2. For objective diagnostics of vaginal dysbacterioses, it is necessary to apply molecular genetic methods of research in the form of PCR reaction in real time and quantitative counting of conditionally pathogenic microorganisms. 4.Лечение вагинальных дисбактериозов должно быть индивидуализированным в зависимости от имеющегося спектра условно - патогенных аэробных и анаэробных бактерий. 3. When determining the type of imbalance of a vaginal microbiota, it is important to evaluate the quantitative changes of the following microorganisms: Lactobacillus, Streptococcus spp., Lachnobacterium spp., Megasphaera spp., And Peptostreptococcus spp., Gardnerella vaginalis and Candida spp. 4. Treatment of vaginal dysbacteriosis should be individualized depending on the available spectrum of conditionally pathogenic aerobic and anaerobic bacteria.

туберкулез, химиотерапия, дисбактериоз, tuberculosis, chemotherapy, dysbacteriosis

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