Analysis of drug resistance indicators of Mycobacterium tuberculosis in the Republic of Mary El for 2007-2017

Abstract

The complex analysis of drug resistance indicators of Mycobacterium tuberculosis to anti-tuberculosis drugs for different categories of tuberculosis patients in the Republic of Mari El for the period from 2007 to 2017 was carried out. There is a significant spread of drug-resistant strains of Mycobacterium tuberculosis even among the new cases of tuberculosis. There is a steady increase in the level of primary and acquired drug resistance, especially multi and extensively drug resistance. The presence in the Republic of Mari El of the bacillary nucleus of chronic forms of tuber-culosis with a wide range of resistance was revealed, which creates prerequisites for the growth of primary drug resistance. To improve the epidemiological situation in the region, it is necessary to op-timize the algorithm of microbiological diagnosis of tuberculosis with the inclusion of methods that ensure the rapid testing of drug resistance to the maximum possible range of anti-tuberculosis drugs. This will make it possible to prescribe adequate treatment in a timely manner and prevent the further development of resistance and the spread of drug-resistant strains of Mycobacterium tuberculosis.