Markers of kidney damage in the diagnosis of infectious-inflammatory in patients with urolithiasis after contact ureterolithotripsy
https://doi.org/10.25694/URMJ.2018.09.22
Abstract
Currently one of the main methods of treatment of patients with ureteral stones is contact ureterolithotripsy (CULT). Despite the high effectiveness of the method, the problem of early detection and prevention of exacerbation of inflammatory complications of nephrolithiasis remains urgent. To improve the diagnosis of pyelonephritis after CULT in patients with urolithiasis, a study of the diagnostic efficacy of neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, ß2-microglobulin, and interleukin-18 was performed in 123 patients with ureteral stones. The greatest value in preoperative diagnostics of pyelonephritis was demonstrated for serum NGAL of blood, urine NGAL, and urine ß2-microglobulin. The most significant increase during early term (2 hours) after CULT was observed for urine ß2-microglobulin and IL-18. The concentration of urine NGAL among all the studied markers remained elevated for a relatively longer period.
About the Authors
A. I. Tarasenko
Башкирский государственный медицинский университет
Russian Federation
Russian Federation
I. R. Kabirov
Башкирский государственный медицинский университет
Russian Federation
Russian Federation
A. V. Alekseev
Башкирский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Tarasenko AI, Kabirov IR, Alekseev AV. Markers of kidney damage in the diagnosis of infectious-inflammatory in patients with urolithiasis after contact ureterolithotripsy. Ural Medical Journal. 2018;(9):56-60. (In Russ.) https://doi.org/10.25694/URMJ.2018.09.22
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