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Effect of use of water, supersaturated with air, to reduce the severity of the cvonsequence of laboratory animals oxidative stress. II. The hypoglycemic action of artesian water with gas nanobubble phase studied on lab rats in conditions of hypercaloric diet and experimental diabet

https://doi.org/10.25694/URMJ.2018.12.39

Abstract

The influence of water with gas nanobubbles on the condition and biochemical parameters of blood of rats in conditions of hypercaloric diet and experimental diabetes was studied. The beneficial effect of water with gas nanobubbles on rats in conditions of a reduced-calorie diet and streptozocin and experimental alloxan diabetes is observed. In rats, which were on an unbalanced diet, including excess fat and carbohydrates, the use of water with nanobubbles maintains a balance in terms of glycosylated hemoglobin, helps to reduce the weight and amount of cholesterol in the serum. In rats with experimental diabetes, the intake of treated water by rats, in the absence of hypoglycemic therapy, leads to a decrease in glucose levels and glycosylated hemoglobin. The effect of water intake is more pronounced in rats with alloxan diabetes. The action of the gas nanobubbles similarly the action of drugs-antioxidants.

About the Authors

E. G. Butolin
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation


O. V. Danilova
ФГБУН Удмуртский федеральный исследовательский центр Уральского отделения РАН
Russian Federation


O. M. Kanunnikova
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation


N. N. Chuchkova
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation


M. V. Smetanina
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation


V. I. Kozhevnikov
ФГБУН Удмуртский федеральный исследовательский центр Уральского отделения РАН
Russian Federation


A. V. Trubachev
ФГБУН Удмуртский федеральный исследовательский центр Уральского отделения РАН
Russian Federation


References

1. Andre I., Gonzalez A., Wang B. Checkpoints in the progression of aut-oummune disease: lessons from diabetes models. Proc Natl Acad Sci USA. 1996; 93: 2260-2263

2. Bayens J.W., Thorpe S.R. Oxidative stress in diabetes. Antioxidants in Diabetes Management. Ed. Packer. New York: M. Dekker Inc. 2000; 58-66.

3. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. 1. Nature. 2001; 414: 813-820.

4. Halliwell B, Gutteridge J.M.C. Free Radicals in Biology and Medicine. 3rd ed. New York: Oxford University Press. 1999: 20-37.

5. Cooper M.E., El-Osta A., Allen T.J., Watson A.M.D., Thomas M.C., Jandeleit-Dahm KAM. Metabolic karma-the atherogenic legacy of diabetes. The 2017 Edwin Bierman Award Lecture. Diabetes. 2018; 67(5): 785-790.

6. Zhou X., Dong J., Zhang L., Liu J., Dong X., Yang Q. et.al. Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model. J Endocrinol. 2015; 224(2): 119-125.

7. Feillet-Coudray C., Rock E., Coudray C., Grzelkowska K., Azais-Braesco V., Dardevet D. et al. Lipid peroxidation and antioxidant status in experimental diabetes. Clin Chim Acta. 1999; 284: 31-43.

8. Vural P., Kabaca G., Firat R.D., Degirmencioglu S. Administration of selenium decreases lipid peroxidation and increases vascular endothelial growth factor in streptozotocin induced diabetes mellitus. Cell J. 2017; 19(3): 452-460.

9. West I.C. Radicals and oxidative stress in diabetes. Diabet Med. 2000; 17: 171-180.

10. Rosen P., Nawroth P., King G. The role of oxidative stress in the onset and progression of diabetes and complications. Diabetes Metab Res. 2001; 17: 189-212.

11. Mahesh T., Menon V.P. Quercetin allievates oxidative stress instreptozotocin-induced diabetic rats. Phytother Res. 2004; 18: 123-127;

12. Young I.S., Torney J.J., Trimble E.R. The effect of ascorbate supplementation on oxidative stress in the streptozotocin diabetic rat. Free Radic Biol Med. 1992; 13: 41-46.

13. Suhail M., Patil S., Khan S., Siddiqui S. Antioxidant vitamins and lipoperoxidation in non-pregnant, pregnant, and gestational diabetic women: erythrocytes osmotic fragility profiles. J Clin Med Res. 2010; 2: 266-273.

14. Shidfar F., Homayounfar R., Fereshtehnejad S.M., Kalani A. Effect of folate supplementation on serum homocysteine and plasma total antioxidant capacity in hypercho-lesterolemic adults under lovastatin treatment: a doubleblind randomized controlled clinical trial. Arch Med Res. 2009; 40: 380-386.

15. Roussel A.M., Kerkeni A., Zouari N., Mahjoub S., Matheau J.M., Anderson R.A. Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr. 2003; 22: 316-321.

16. Hamdiken M., Bouhalit S., Kechrid Z. Effect of ruta chalepensis on zinc, lipid profile and antioxidant levels in the blood and tissue of streptozotocin-induced diabetes in rats fed zinc-deficient diets. Can J Diabetes. 2017; pii: S1499-2671(17): 30078-30083.

17. Melo da Cunha J.D.S., Alfredo T.M., Dos Santos J.M., Alves Junior V. V., Rabelo L.A., Lima E.S. et al. Antioxidant, antihyperglycemic, and antidiabetic activity of Apismellifera bee tea. PLoS One. 2018; 13(6): e0197071.

18. Yu Y.M., Chang W.C., Chang C.T., Hsieh C.L., Tsai C.E. Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes. Diabetes Metab. 2002; 28: 107114.

19. Kim H.Y., Jeon E.J., Park Y.K., Kang M.H. Effect of deer antler drink supplementation on blood pressure, blood glucose and lymphocyte DNA damage in type 2 diabetic patients. Korean J Nutr 2004; 37: 794-800.

20. Lee S.H., Lee H.J., Lee Y.H., Lee B.W., Cha B.S., Kang E.S. et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother Res. 2012; 26: 142-147.

21. Hininger-Favier I., Benaraba R., Coves S., Anderson R.A., Roussel A.M. Green tea extract decreases oxidative stress and improves insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat. J Am Coll Nutr. 2009; 28: 355-361.

22. Escudero-López B., Ortega A., Cerrillo I., Rodnguez-Grinolo M.R., Munoz-Hernändez R., Macher H.C. et al. Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers in healthy humans. J Sci Food Agric. 2018; 98(7): 2777-2786.

23. Bonamigo T., Campos J.F., Oliveira A.S., Torquato H.F.V., Balestieri J.B.P., Cardoso C.A.L. et al. Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome. PLoS One. 2017; 12(9): e0183983.

24. Ha B.G., Moon D.S., Kim H.J., Shon Y.H. Magnesium and calcium-enriched deep-sea water promotes mitochondrial biogenesis by AMPK-activated signals pathway in 3T3-L1 preadipocytes. Biomed Pharmacother 2016; 83: 477-484.

25. Naumann J., Biehler D., Lüty T., Sadaghiani C. Prevention and therapy of type 2 diabetes-what is the potential of daily water intake and its mineral nutrients? Nutrients. 2017; 9(8): pii: E914.

26. Hye-Jin Lee, Myung-Hee Kang. Effect of the magnetized water supplementation on blood glucose, lymphocyte DNA damage, antioxidant status, and lipid profiles in STZ-induced rats. Nutr Res Pract, 2013; 7(1): 34-42.

27. Западнюк И.П., Западнюк В.И., Захария Е.А., Западнюк Б.В. Лабораторные животные. Разведение, содержание, использование в эксперименте. 3-е издание, переработанное и дополненное. Киев: Вища школа. Головное изд-во; 1983.

28. Балаболкин М.И. Диабетология. М.: Медицина; 2000.

29. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Diabetologia. 2001; 50(6): 536-546.

30. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008; 51: 216 - 226.

31. Николаева О.В., Ковальцова М.В., Татарко С.В., Литвиненко Е.Ю. Влияние не сбалансированного питания с повышенным содержанием углеводов и жиров на морфофункциональное состояние поджелудочной железы беременных крыс и их потомства. Вестник проблем биологии и медицины. 2014; 3(2): 109.


Review

For citations:


Butolin EG, Danilova OV, Kanunnikova OM, Chuchkova NN, Smetanina MV, Kozhevnikov VI, Trubachev AV. Effect of use of water, supersaturated with air, to reduce the severity of the cvonsequence of laboratory animals oxidative stress. II. The hypoglycemic action of artesian water with gas nanobubble phase studied on lab rats in conditions of hypercaloric diet and experimental diabet. Ural Medical Journal. 2018;(12):150-154. (In Russ.) https://doi.org/10.25694/URMJ.2018.12.39

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