Preview

Ural Medical Journal

Advanced search

Importance of biochemical markers in the diagnosis of congenital malformations of the fetus

https://doi.org/10.25694/URMJ.2018.03.011

Abstract

The study of diagnostic importance of biochemical screening of pregnant women on AFP and hCG for detection of congenital hereditary diseases was conducted. The main group consisted of 109 patients, in who congenital malformations and/or chromosomal anomalies of fetus or infant were diagnosed prenatally or after the birth. The control group consisted of 280 patients of RPC, whose pregnancy ended with the birth of children without congenital heredity diseases. The sufficiently high efficiency of detection in serum of blood AFP and hCG in the 2nd trimester of pregnancy during the formation of a risk group for congenital malformations (CM) and the chromosomal anomalies is shown in the article.

About the Authors

Z. U. Amaeva
ГБОУ ВПО «Дагестанская государственная медицинская академия» МЗ РФ
Russian Federation


N. S.-M. Omarov
ГБОУ ВПО «Дагестанская государственная медицинская академия» МЗ РФ
Russian Federation


D. K. Kantaeva
ГБОУ ВПО «Дагестанская государственная медицинская академия» МЗ РФ
Russian Federation


References

1. Врожденные пороки развития: пренатальная диагностика и тактика /Под ред. Петриковского Б.М.,Медведева М.В., Юдиной Е.В. М.: РАВУЗДПГ, Реальное Время, 2011.

2. Лазюк Г.И., Лурье И.В., Черствой Е.Д. Наследственные синдромы множественных врожденных пороков развития. М.: Медицина, 2013.

3. Пренатальная диагностика врожденных пороков развития в ранние сроки беременности / Под ред. Медведева М.В. М.: РАВУЗДПГ, Реальное Время, 2013; 217.

4. Пренатальная диагностика врожденных пороков развития плода: пер англ. / Ромеро Р., Пилу Дж.э Дженти Ф. и др.; пер. англ. М.: Медицина, 2014; 448.

5. Русанова О.Н. Проблемы пренатальной диагностики. Пренат. Диагн. 2013; 4(2):89-93.

6. Ajayi R.A., Keen C.E., Knott P.D. Ultrasound diagnosis of the Pena Shokeir phenotype at 14 weeks of pregnancy. Prenat. Diagn. 2013; 15: 762- 764.

7. Carvalho M.H.B., Brizot M.L., Lopes L.M. et al. Detection of fetal structural abnormalities at the 11-14 week ultrasound scan. Prenat. Diagn. 2012; 22 (1) 1-4.

8. Cazorla E., Ruiz F., Abad A., Monleon J. Prune-belly syndrome: early antenatal diagnosis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 72:31-33.

9. Cynthia A. Moore, Song Li, Zhu Li, Shi-xin Hong at al. Elevated Rates of Severe Neural Tube Defects in a High-Prevalence Area in Northern China.American Journal of Medical Genetics 2011; 73:113-118.

10. Den Hollander N.S., van der Harten H.J., Vermeij-Keers С et al. First trimester diagnosis of blomstrand lethal osteochondrodysplasia. Amer. J. Med. Genet. 2013; 73 : 345-350.


Review

For citations:


Amaeva ZU, Omarov NS, Kantaeva DK. Importance of biochemical markers in the diagnosis of congenital malformations of the fetus. Ural Medical Journal. 2018;(3):72-75. (In Russ.) https://doi.org/10.25694/URMJ.2018.03.011

Views: 115


ISSN 2071-5943 (Print)
ISSN 2949-4389 (Online)