Content and Properties of Magnesium Compounds in Some Dietary Supplements
I. N. Kupriyanova,
N. A. Belokonova,
O. M. Medvedeva,
O. A. Melnikova,
E. I. Tikhomirova,
I. G. Kasatkina https://doi.org/10.52420/umj.25.2.7
EDN: CFPDZI
Abstract
Introduction. Magnesium deficiency is a pressing public health problem. To prevent it, the use of biologically active supplements containing magnesium complexes is recommended.
Objective is to study the chemical composition of dietary supplements, evaluate the magnesium content taking into account the solubility at different pH values and the lipophilicity of magnesium compounds to predict their bioavailability.
Materials and methods. Five types of magnesium dietary supplements were studied. Bioavailability was assessed by potentiometry and trilometry when dissolved in water and dilute hydrochloric acid, and the lipophilicity was additionally assessed.
Results. The samples showed significantly better solubility of magnesium in an acidic environment than in water. The Mg content in one tablet or capsule was less than indicated on the package, with the exception of sample 5. The study of the lipophilic properties of complex compounds and salts of Mg by distribution in butanol showed that from 5 % to 58 % of lipophilic compounds are formed in an acidic environment. The content of amorphous silicon dioxide in sample 4 as an anti-caking agent increases the pH of the aqueous solution to 9.9, which has practical relevance for prescribing these dietary supplements to patients with various pH-dependent pathologies.
Conclusion. Laboratory-obtained parameters (solubility, pH level and lipophilicity) allow us to predict the potential bioavailability of magnesium salts from dietary supplements when taken orally by patients.
About the Authors
I. N. Kupriyanova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Inessa N. Kupriyanova — Candidate of Sciences (Medicine), Associate Professor of the Department of Faculty Therapy, Allergology, and Immunology, Institute of Clinical Medicine
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
N. A. Belokonova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nadezhda A. Belokonova — Doctor of Sciences (Enginery), Candidate of Sciences (Chemistry), Professor, Head of the Department of General Chemistry, Institute of Clinical Pharmacology and Pharmacy
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
O. M. Medvedeva
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga M. Medvedeva — Candidate of Sciences (Chemistry), Associate Professor of the Department of Gen‑ eral Chemistry, Institute of Clinical Pharmacology and Pharmacy
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
O. A. Melnikova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga A. Melnikova — Doctor of Sciences (Pharmaceutics), Professor, Professor of the Department of Pharmacy, Institute of Clinical Pharmacology and Pharmacy
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
E. I. Tikhomirova
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena I. Tikhomirova — Candidate of Sciences (Chemistry), Associate Professor of the Department of Gener‑ al Chemistry, Institute of Clinical Pharmacology and Pharmacy
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
I. G. Kasatkina
Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Irina G. Kasatkina — Assistant of the Department of General Chemistry, Institute of Clinical Pharmacology and Pharmacy
Ekaterinburg
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest
References
1. Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Archives of Biochemistry and Biophysics. 2007;458(1):40–47. DOI: https://doi.org/10.1016/j.abb.2006.05.007.
2. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium: An update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 2000;294(1–2):1–26. DOI: https://doi.org/10.1016/S0009-8981(99)00258-2.
3. Rosanoff A, Dai Q, Shapses SA. Essential nutrient interactions: Does low or suboptimal magnesium status interact with vitamin D and/or calcium status? Advances in Nutrition. 2016;7(1):25–43. DOI: https://doi.org/10.3945/an.115.008631.
4. Dai Q, Zhu X, Manson JE, Song Y, Li X, Franke AA, et al. Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial. The American Journal of Clinical Nutrition. 2018;108(6):1249–1258. DOI: https://doi.org/10.1093/ajcn/nqy274.
5. Newhouse IJ, Finstad EW. The effects of magnesium supplementation on exercise performance. Clinical Journal of Sport Medicine. 2000;10(3):195–200. DOI: https://doi.org/10.1097/00042752-200007000-00008.
6. Topf JM, Murray PT. Hypomagnesemia and hypermagnesemia. Reviews in Endocrine and Metabolic Disorders. 2003;4(2):195–206. DOI: https://doi.org/10.1023/a:1022950321817.
7. Barbagallo M, Reddy ST, Soman SS, Yee J. Magnesium balance and measurement. Advances in Chronic Kidney Disease. 2018;25(3):224–229. DOI: https://doi.org/10.1053/j.ackd.2018.03.002.
8. De Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: Implications for health and disease. Physiological Reviews. 2015;95(1):1–46. DOI: https://doi.org/10.1152/physrev.00012.2014.
9. Pethő ÁG, Fülöp T, Orosz P, Tapolyai M. Magnesium is a vital ion in the body — it is time to consider its supplementation on a routine basis. Clinics and Practice. 2024;14(2):521–535. DOI: https://doi.org/10.3390/clinpract14020040.
10. Quamme GA. Recent developments in intestinal magnesium absorption. Current Opinion in Gastroenterology. 2008;24(2):230–235. DOI: https://doi.org/10.1097/MOG.0b013e3282f37b59.
11. Schuchardt JP, Hahn A. Intestinal absorption and factors influencing bioavailability of magnesium — an update. Current Nutrition & Food Science. 2017;13(4):260–278. DOI: https://doi.org/10.2174/1573401313666170427162740.
12. Gromova OA, Torshin IYu, Kodentsova VM. Food products: Content and absorption of magnesium. Therapy. 2016;(5):87-96. (In Russ.). EDN: https://elibrary.ru/XCFZUJ.
13. Vormann J. Magnesium: Nutrition and metabolism. Molecular Aspects of Medicine. 2003;24(1–3):27–37. DOI: https://doi.org/10.1016/s0098-2997(02)00089-4.
14. Martynov AI, Baranov II, Orlova SV, Akarachkova ES, Gromova OA, Malyavin AG, et al. Resolution of the expert council “Magnesium Deficiency”. Therapy. 2024;10(1):149–158. (In Russ.). DOI: https://doi.org/10.18565/therapy.2024.1.149-158.
15. Pardo MR, Garicano VE, San Mauro Martín I, Camina Martín MA. Bioavailability of magnesium food supplements: A systematic review. Nutrition. 2021;89:111294. DOI: https://doi.org/10.1016/j.nut.2021.111294.
16. Tereshchenko IV. Magnesium deficiency in an endocrinologist’s practice. Clinical Medicine (Russian Journal). 2008;86(7):47–51 (In Russ.). EDN: https://elibrary.ru/TKTWDB.
17. Gromova OA, Torshin IYu, Kobalava ZhD, Sorokina MA, Villevalde SV, Galochkin SA, et al. Deficit of magnesium and states of hypercoagulation: Intellectual analysis of data obtained from a sample of patients aged 18–50 years from medical and preventive facilities in Russia. Kardiologiia. 2018;58(4):22–35. (In Russ.). DOI: https://doi.org/10.18087/cardio.2018.4.10106.
18. Nizovtseva OA. Complex therapy of cardiovascular diseases and magnesium deficiency. Difficult Patient. 2014;12(7):37–41. (In Russ.). EDN: https://elibrary.ru/TFSIVX.
19. Marze S. Bioavailability of nutrients and micronutrients: Advances in modeling and in vitro approaches. Annual Review of Food Science and Technology. 2017;8:35–55. DOI: https://doi.org/10.1146/annurev-food-030216-030055.
20. Bawiec P, Jaworowska A, Sawicki J, Czop M, Szalak R, Koch W. In vitro evaluation of bioavailability of mg from daily food rations, dietary supplements and medicinal products from the Polish market. Nutrients. 2025;17(5):748. DOI: https://doi.org/10.3390/nu17050748.
21. Blancquaert L, Vervaet C, Derave W. Predicting and testing bioavailability of magnesium supplements. Nutrients. 2019;11(7):1663. DOI: https://doi.org/10.3390/nu11071663.
22. Belokonova NA, Medvedeva OM, Bozhko YaG, Arkhipov MV. Physicochemical properties of magnesium-containing drugs. Proceedings of Voronezh State University. Series: Chemistry. Biology. Pharmacy. 2024;(1):5–13. (In Russ.). EDN: https://elibrary.ru/CLKOHI.
23. Bozhko YaG, Belokonova NA, Medvedeva OM, Butova KA, Arkhipov MV. Replenishment of intracellular magnesium deficiency in cardiac arrhythmia: Focus on the physicochemical properties of complex compounds. Rational Pharmacotherapy in Cardiology. 2025;21(2):155–165. (In Russ.). DOI: https://doi.org/10.20996/1819-6446-2025-3149.
24. Iezhitsa IN, Kravchenko MS, Kharitonova MV, Spasov AA, Ozerov AA. Comparative bioavailability of some organic magnesium salts and magnesium-containing preparations under conditions of alimentary hypomagnesemia. Journal of Volgograd State Medical University. 2007;(4):40–43. (In Russ.). EDN: https://elibrary.ru/KFQWLP.
25. Antoshkina EG, Smolko VA. Determination of acid-base centers on the surface of quartz sand grains from some Russian deposits. Bulletin of the South Ural State University. Series: Mathematics, Physics, Chemistry. 2008;(7):65–68. (In Russ.). EDN: https://elibrary.ru/IYDCRP.
26. Arefieva OD, Pirogovskaya PD, Panasenko AE, Kovekhova AV, Zemnukhova LA. Acid-base properties of amorphous silicon dioxide from rice straw and husk. Chemistry of Plant Raw Materials. 2021;(1):327–335. (In Russ.). DOI: https://doi.org/10.14258/jcprm.2021017521.
27. Ikonnikova KV, Ikonnikova LF, Minakova TS, Sarkisov YuS. Theory and practice of pH-metric determination of acid-base properties of solid surfaces: A tutorial. Tomsk: Tomsk Polytechnic University Publishing House; 2011. 85 p. (In Russ.). EDN: https://elibrary.ru/TITKEJ.
28. Puścion-Jakubik A, Bartosiewicz N, Socha K. Is the magnesium content in food supplements consistent with the manufacturers’ declarations? Nutrients. 2021;13(10):3416. DOI: https://doi.org/10.3390/nu13103416.
29. Ivanovic ND, Radosavljevic B, Zekovic M, Korcok D, Ignjatovic S, Djordjevic B, et al. Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. BioMetals. 2022;35(2):267–283. DOI: https://doi.org/10.1007/s10534-022-00363-y.
30. Abraham GE, Schwartz UD, Lubran MM. Effect of vitamin B 6 on plasma and red blood cell magnesium levels in premenopausal women. Annals of Clinical & Laboratory Science. 1981;11(4):333–336. PMID: https://pubmed.gov/7271227.
31. Uysal N, Kizildag S, Yuce Z, Guvendi G, Kandis S, Koc B, et al. Timeline (bioavailability) of magnesium compounds in hours: Which magnesium compound works best? Biological Trace Element Research. 2019;187(1):128–136. DOI: https://doi.org/10.1007/s12011-018-1351-9.
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For citations:
Kupriyanova IN, Belokonova NA, Medvedeva OM, Melnikova OA, Tikhomirova EI, Kasatkina IG. Content and Properties of Magnesium Compounds in Some Dietary Supplements. Ural Medical Journal. 2026;25(2):7–19. (In Russ.) https://doi.org/10.52420/umj.25.2.7. EDN: CFPDZI
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