Insulin and leptin: disputable and unsolved questions of their interaction in obesity
https://doi.org/10.25694/URMJ.2019.03.16
Abstract
Leptin and its receptor are widely distributed mainly in white adipose tissue. Serum leptin concentration correlates with body mass index, and its levels decrease with fasting. Insulin appears to increase leptin messenger RNA, protein expression and release by adipocytes, both synthesized both in advance and de novo, and reduces the levels of adiponectin and its receptors. According to the literature, chronic hyperinsulinemia increases leptin levels. This review summarizes the latest knowledge on the effect of insulin on leptin synthesis and secretion; cellular mechanisms that control the synthesis and release of white adipose tissue are presented.
Keywords
лептин,
инсулин,
адипоциты,
ожирение,
инсулинорезистентность,
leptin,
insulin,
adipocytes,
obesity,
insulin resistance
About the Authors
E. V. Belik
ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний
Russian Federation
Russian Federation
O. V. Gruzdeva
ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
E. I. Palicheva
ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Belik EV, Gruzdeva OV, Palicheva EI. Insulin and leptin: disputable and unsolved questions of their interaction in obesity. Ural Medical Journal. 2019;(3):17-24. (In Russ.) https://doi.org/10.25694/URMJ.2019.03.16
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