Indicators of the quality of life in children with obesity and hypertension and in healthy children aged 10 to 17 years on the international validated questionnaire were investigated Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0). The quality of life in children with obesity and hypertension was lower in all studied scales than in the control group, while the probability of its decrease was 7.5 times higher, compared with healthy peers. The greatest impact of obesity and hypertension on the decline in quality of life was determined for the scale of physical functioning and functioning in school. The relationship of the quality of life with body mass index, the severity of metabolic disorders (insulin resistance, dyslipidemia), and upbringing in single parent family has been established in children with obesity and hypertension. The obtained results indicate a significant effect of obesity and hypertension on the reduction of quality of life in children.

To study the prevalence of minimal brain dysfunction (MBD) in children of preschool age in the city of Makhachkala 600 children were examined. In result of the conducted research it is established that MMD is observed in 72(12%) children. The symptoms of MMD were often found in children from 2.5 to 4.5 years - 48(8%).In mothers of children with MMD the complications were found during gestation in 61 (10,7%) cases. In the first year in children with MMD inflammatory diseases and 91.4%, complications inflammatory were observed: intracranial hypertension of 26.0%, complications after vaccination 83,0%, traumatic brain injury is 21.4%.

To study and evaluate the psychomotor development of children from the neonatal period to one year, undergoing neonatal intensive care, 64 children born in asphyxia were examined: the I - group 36, full-term, II - 28 preterm group and the control group included 35 healthy term infants. In the result of the study, it was found that in children, who suffered hypoxic-ischemic lesion of the Central nervous system and neonatal intensive care, regardless of the time of birth, the inhibition of motor activity and muscle tone is observed, and there is a gap in the physical and psychomotor development in contrast to children in the control group.

The average for 2002 - 2016 mortality from malignant neoplasms of the population of the Republic of Dagestan is significantly less than 1.5 times compared with the Russian Federation. In the South of Russia, the Stavropol Territory, Dagestan, Karachaevo-Cherkessia and the Rostov Region are the most affected by the mortality from hemoblastosis in boys and girls; while the deaths from hemoblastosis in boys exceed similar indicators for girls in Russia, Southern and North - Caucasian federal districts, and also for subjects of the South of Russia; According to Dagestan, the excess mortality of boys is 45% compared to the indicator for girls, but without certainty. The prognostic tendency of mortality from hematological malignancies of the children's population has significant features in the comparative areas of the South of Russia with elements of different directions.

Laminate technique, or the so-called sandwich technique restoration of posterior group of teeth involves the use of glass ionomer cement and composite material in sequence. The relatively weak mechanical bond between glass ionomer cement and composite at the end of time could lead to the disruption of adhesion. With the advent of new materials, adhesive systems, we believe it is necessary to review the classical technique of the combined use of glass ionomer cement and composite materials. This article is aimed to evaluate the adhesion force between glass ionomer cement and composite material using different adhesive systems and curing techniques.

Modern level of knowledge of parodontium pathology pathogenesis defines the concept of inflammation as the dominant one in the result effect “contagium - owner”. The key molecules of inflammation are the cytotoxicans. The cytotoxicans response is defined genetically. The cytotoxicans gene expression starts in response to pathogene penetration, antigenic excitation, tissue damage. Therefore the detection of candidate genes of genetic predisposition, expression polymorphism of which defines the clinical implications polymorphism, opens wide perspectives in learning of the genetic determination of dental pathology of phlogistic habit.

The polymorphisms of TNF-agene in G( - 308)→ A in patients suffering from chronic generalized periodontitis were studied in connection with the local antibiotic therapy of periodontal tissues efficiency. The conducted course of antibiotic treatment, that was administered with a glance for periodontal pocket microflora sensitivity to antibiotics, was established to be less effective in the patients suffering from chronic generalized periodontitis and being carriers of pathological polymorphisms «G / G» and «G / A» than in patients with chronic generalized periodontitis, carriers of the polymorphism A / A.

Aim. To evaluate the quality of life of patients who use removable dentures after conducted parodontal surgery on preprosthetic stage of preparation. Methods. A clinical examination and periodontal surgical treatment were conducted, and assessment of quality of life 67 patients aged 65 to 80 years, who formerly held the prosthetics full removable dentures, but people who use them for reasons of difficult chewing of food in connection with the pain under the denture, balancing of the denture while talking and eating, the presence of growths on the mucous membrane under the prosthesis, but also discomfort and lack of habituation to the prosthesis and participated, was also conducted. Results. According to OHIP-14 survey for evaluation of quality of living of parodontal patients, who use fully removable dentures, was conducted three times: before the treatment, after conducted parodontal surgery and after the ending of repeated prosthetics to fully removable prostheses after 6 months. Conclusion. According to the conducted research: survey for patients in oral form and clinical assessment - it was established that on the stage of preparation before orthopedic rehabilitation by fully removable constructions, the parodontal treatment is neglected, the elimination mucogingival pathology in particular, that leads to the inability to use removable dentures in everyday life.

The aim: to assess the severity of the violation of some cognitive and neuropsychological functions in young patients with SAK for the subsequent development of algorithms for differentiated treatment and rehabilitation. Material and methods of the study: a group of the examined patients who underwent SBA under the age of 45 years was 135 people, the average age was 39.5 ± 3.4 years. After repeated randomization, this group was divided into patients with phenotypic signs of DST (99 people - 73.3% - basic group) and without it (36 people - 26.7% - comparison group). A general examination and examination of internal organs, a neurologic examination according to a conventional scheme using traditional methods with an assessment of the main functional systems and determining the depth of their damage, determination of constitutional types, evaluation of the degree of phenotypic manifestations of DST, neuropsychological examination, general clinical laboratory, neurovisualizational, and statistical were conducted. The analysis of the obtained results showed that by the end of the acute period of the SAK, a qualitatively different structure of errors occurred in a neuropsychological study in groups of young patients with SAK with signs of connective tissue dysplasia and without it. It can be assumed that the revealed risk factors for the development of SAK already in the premorbid period create conditions for the formation of chronic cerebral ischemia in both groups, but just in the main group - dysplastic changes in the vessels, and in the comparison group - traditional vascular risk factors. The relationship between the presence of signs of DST and the restoration of neuropsychological functions of the patient is traced. Patients of a young age with phenotypic and visceral signs of DST are distinguished by the best regression of the neurological deficit in the dynamics of the disease in comparison with the comparison group without signs of DST. The obtained data can be useful for the subsequent development of algorithms of the differentiated approach of treatment and rehabilitation of this category of patients.

The purpose of the study: to study the concomitant pathology with regard to sex and age of patients with acute coronary syndrome. Materials and methods. The study included 1079 patients with acute coronary syndrome who received treatment at Cardiology Department No. 2 of the State Regional Clinical Hospital "Chelyabinsk Regional Clinical Hospital”. All patients enrolled in the study are divided into clinical forms of acute coronary syndrome and age groups according to international classification of diseases - 10. Statistical analysis is performed using Microsoft Office applications and SPSS Statistics (version 20.0). Results. Analysis of the results showed that male patients were hospitalized more often than women (p = 0.009). In cases with men, ST - segment elevation myocardial infarction was more often diagnosed, whereas in cases with women unstable angina prevailed. There were no significant differences in the incidence of non - ST - segment elevation myocardial infarction. An analysis of age distribution showed that in both men and women, ACS more often developed at the age of 55 - 64 years. A comprehensive assessment of the history of the anamnesis showed that among all 1079 patients 2180 diseases were identified. Among patients with ST - segment elevation myocardial infarction, on average, 1 patient had 1.9 diseases, with non - ST - segment elevation myocardial infarction - 2.3 diseases, with unstable angina - 2.2 diseases. The most frequent concomitant diseases are diseases of the circulatory system, in the second place - diseases of the endocrine system, in the third place - diseases of the digestive system. The conclusion. The identification and analysis of concomitant pathology before the onset of an acute coronary situation play an important role in the prevention, course and outcome of vascular pathology.

The article contains a literature review of domestic and foreign scientific publications over the past 15 years devoted to a total hip replacement in cases of acetabular bone defects and deformations. The article presents the widely used classification of defects and deformations of the acetabulum, the technique of implanting cups prosthesis, modern surgical methods of reconstruction of the acetabulum. Primary stable fixation of the cup prosthesis in the clinical cases of the acetabular bone defects, according to the literature, can be achieved under the condition of restoring сеnter of the hip rotation in real acetabular area, plasty of the bone defects by structural bone auto - and allograft, trabecular metal and reconstruction rings.

The article contains a literature review of domestic and foreign scientific publications over the past 15 years devoted to the diagnosis and treatment of periarticular proximal femur fractures. The work presents the widely used classification of data damage, indications for surgical treatment, especially the application of internal fixation characteristics and justification of choice of modern devises timely surgical treatment performed with the restoration of the integrity of the medial calcar integrity and initially stable osteosynthesis anchor strongly allow, according to the literature, to achieve good functional results.

The modern views and experience of different schools in the search of optimal cure to prevent the most common complication in abdominal surgery and operative gynecology - postoperative adhesions of peritoneum were analyzed and were generalyzed. The results of individual studies on prevention of adhesions of peritoneum are encouraging, but the prevalence of this complication and the costs of healthcare system show the lack of universal anti - adhesive cure. The selective development of this postoperative complication in operated patients in the same conditions is also unclear.

The problem of peptic ulcer disease remains one of the most actual in modern gastroenterology due to the high prevalence of the disease, a chronic relapsing course, leading to a significant reduction and loss of earning capacity. The purpose is to evaluate the efficacy of intragastric low-intensive laser therapy in complex treatment of patients with gastric ulcer and 12 duodenal ulcer. Material and methods. The study included 50 patients with peptic ulcer who by means of a simple randomization divided into groups - basic and control. The main group received complex low - intensity laser therapy on the background of drug anti - ulcer therapy, the control group standard anti - ulcer therapy. Results. Using the method of EGD studies have provided evidence of activation of regenerative processes of the mucous membrane of the stomach and 12 duodenal ulcer. A comparative analysis of the dynamics of patients' condition showed that epithelialization and scarring ulcers in 93% of patients of the main group occurs on the 2nd and 3rd week of treatment, whereas patients of the control group in these terms epithelialization and scarring is noted in 70% of patients. The result of the treatment found that intragastric laser therapy on the background of anti - ulcer drug therapy contributes to efficient recovery of the mucous membrane, activation of regenerative processes. In the control group the changes were less important. Conclusion. The use of intragastric low - intensity laser therapy on the background of drug anti - ulcer therapy of patients with peptic ulcer disease helps accelerate the healing of ulcerative and erosive processes, leads to regression of clinical and functional disorders.

Peptic ulcer and 12 duodenal ulcer are common disorders of the digestive system the upper gastrointestinal tract, which significantly reduces the quality of life and health of patients. Objective: to evaluate the effectiveness of the intragastric application of ozone therapy in the rehabilitation of patients with gastric ulcer and 12 duodenal ulcer. Material and methods. The study included 54 patients with peptic ulcer disease, which the method of simple randomization divided into groups - basic and control. The main group received complex ozone applications on the background of anti - ulcer therapy, the control group standard anti - ulcer therapy. Results. Using the method of ELISA was obtained evidence of the source of pathological changes of the immune status in the form of higher values of JgA and JgG, JgM reduced and reduced anti - inflammatory (IL-4, IL-10) and higher values of proinflammatory (IL-1 ß, IL-6, TNF) cytokines in patients with gastric ulcer and 12 duodenal ulcer. The result of the treatment found that intragastric ozone therapy in the form of applications on the background of anti - ulcer drug therapy contributes to efficient recovery of the immune status, immunoglobulin against the background of the regression of the inflammatory phenomena. In the control group the changes were less important. Conclusion. Intragastric application of ozone therapy in the form of an application on the background of anti - ulcer therapy of patients with peptic ulcer disease contributes to the restoration of immunological reactivity, leads to regression of clinical functional disorders and the improvement of quality of life.

50 patients with executed operation a subtotal colectomy (SCE) for the last 5 years concerning the chronic colostasis (CC) are examined; indications to surgical treatment of CC were lack of effects of conservative therapy within 2,5 years and a chair delay more than 120 hours in a combination and without abdominal painful a syndrome. According to the terms of the postoperative period - up to 1 year there were 11 patients, 2 years - 11, 3 years - 12, 4 years - 4, 5 years - 5, 6 years - 4 and 7 - years - 3 patients. There were 45 women,5 men, whose average age was 41 years (from 17 to 71 years).The quality of SCE surgery in the long - term postoperative period was assessed using the Visick scale, the quality of life was based on a modified Japanese questionnaire. After SCE performed for CC in the long postoperative period, good results of Visick surgery were observed in 56% of patients, satisfactory in 38% and unsatisfactory results in 6% of patients; a good quality of life was defined in 60.2% of patients, satisfactory in 20.8%, and unsatisfactory in 10% of patients. In process of increase in the post - operational period (more than 5 years) after a subtotal colectomy there is an improvement in the quality of both the operation and the life of patients.

To study the current epidemiological situation of skin melanoma in the Urals Federal District, data on the absolute, coarse and standardized incidence rates of melanoma (C43) in the male and female populations were analyzed. The analyses of specific gravity of melanoma patients detected actively at different stages of the tumor process that died during the first year from the date of diagnosis in 2016 was carried out. Higher rates of melanoma morbidity exceeding the average district rates by 29.41% were registered in the Sverdlovsk region. In the Ural Federal District, the incidence of melanoma among women in rough indicators is 1.4 times higher than the incidence in men. The standardized death rate of the population of the Ural FD from skin melanoma is lower than the average for the Russian Federation. The specific gravity of actively detected melanoma patients in the Sverdlovsk Region is 1.3 times higher than the average indicator. The Urals Federal District, among all the Federal Districts of the Russian Federation, has the greatest proportion of patients identified at the first stage (37.6%). The high rates of neglect and one - year lethality in skin melanoma justify the need to develop and conduct additional preventive measures, the introduction of new non - invasive methods for diagnosing skin lesions into practice, and a program for examining patients, especially with suspected skin melanoma.

For the purpose of comparative analysis of the incidence acne of teenage in seaside and non - maritime towns, an epidemiological study of 64,451 acne teenage patients (15 - 17 years), first detected in life in 2004 - 2012, conducted in the towns of the Republic of Dagestan (RD). The towns of the RD divided into two groups: the seaside 5 towns located off the coast of the Caspian Sea, and the non - maritime 5 towns - at a distance of 30 km and more from the sea. The results of the study show a 7 - fold increase in the incidence of acne vulgaris in adolescents compared with children and adults. The critical town for the acne is Khasavyurt, exceeding the average annual rate by 5.2 times compared with the incidence in all towns. In all towns of the RD there is a tendency to increase the incidence of teenage acne. Thus, the growing trend in the incidence of acne among adolescents points to the need to develop a program for the prevention of acne, taking into account the characteristics of disadvantaged towns located far from the sea.

"Stone path” is a condition in which there is accumulation in the ureter of sand and small fragments of stone after a session of remote shock wave lithotripsy (ESWL). The formation of an extended "stone path" (more than 1.5 cm) depends on the internal and transitional type of the pelvis structure, as well as on the density of the calculus. We have studied the possibility of using balneological treatment, including ingestion of mineral water for the purpose of controlled stimulation of diuresis in patients who underwent ESWL, who had a risk of forming a "stone path" in the postoperative period. The study involved 97 patients who underwent clinical rehabilitation in outpatient and sanatorium - resort conditions between 2015 and 2017.

The aim of the study was to evaluate the effectiveness of the combined effect of ultrasonic cavitation irrigation of the uterine cavity and peloid dyspnea with hyposulfitic mud on the change in the level of proinflammatory cytokines in women after the interruption of an undeveloped pregnancy. 80 women were included in the study after the interruption of an undeveloped pregnancy in a period of up to 12 weeks. In the complex of therapy, the patients underwent cavitation ultrasonic irrigation of the uterine cavity with 0.05% chlorhexidine solution in combination with the rectal administration of mud tampons and applications to the "panties" zone. Using the method of ultrasonic cavitation irrigation of the uterine cavity in combination with peloidotherapy in women with regressing pregnancy leads to a decrease in the level of primary mediators of the inflammatory response. In the group using only standard therapy, no significant reduction was observed.

Obstetricians interest to the eye pathology is connected with the choice of tactics while looking after women expecting babies and the way of their childbirth if the pregnant patients have any eye pathology. Nowadays this question is opened to discussion, according to the literature. The frequency of performing Caesarian section reaches 10 - 30% if expectant mothers have any eye disease. Nevertheless, the reason for surgical childbirth is retinal detachment or its threat in most cases. The most frequent reason for retinal detachment is vitreochorioretinal retinal dystrophy, that about 14,6% of women at childbearing age are often ill. In this article the facts concerning ophthalmologic inspections of pregnant women have been systematized. All the women expecting babies must be examined by ophthalmologist before 28 - 30 week of pregnancy and must be examined using ophthalmoscopy in condition of the highest possible medical midriatic. If retinal tears or retinal detachment are found, laser photocoagulation is strongly recommended. If pregnant women have from high to medium myopia, they must be examined every 3 months. The next ophthalmologic examination is recommended during 32 - 36 week of pregnancy. After that ophthalmologist makes the final conclusion about the choice of way of childbirth considering ophthalmologic indications. Despite the fact, that ophthalmologist makes the conclusion about the preferred method of childbirth, the decision in each specific case must be made advisory together with obstetrician - gynecologist, who supervises the pregnant woman.

A new operating procedure of G0 submucous fibroid was developed based on the analysis of 39 office hysteroscopic myomectomies performed with small - diameter hysteroscope (4 - 5 mm) and diode laser. To conduct comparative analysis of the suggested and conventional technique of myomectomy patients were subdivided into 2 main groups and one control group, each group consisted of 13 individuals. The usage of the suggested technique during the surgery, as compared to the conventional techniques of myomectomies, made it possible to reduce the duration of the surgery, to decrease intraoperative blood loss, and to avoid traumatization of the cervix uteri.

The dependence of the frequency of different illness in children born by Caesarean section (CS) and by vaginal delivery was analyzed. Data were processed using the Statistica software package. The statistical analysis revealed significant differences in frequency of illness of endocrine system and allergy in children born by CS and by vaginal delivery. The risk factors of various diseases, which frequency was significantly higher among children born by CS, were established.

To study the antioxidant efficacy of aminodihydrophthalazinedione sodium (galavit), 180 patients with brucellosis were examined. The "before - after" study showed that complex therapy with the inclusion of galavit (intramuscularly at 100 mg twice a day for 2 days, then 100 mg every other day for 10-15 days) of patients with brucellosis of women is accompanied by a significant decrease in lipid peroxidation at all forms of brucellosis. Dynamic changes in the concentration of sulfhydryl groups in the blood tend to increase, while the concentration of disulfide groups increases with acute and subacute brucellosis, and in chronic brucellosis it decreases. Thioldisulfide coefficient in the treatment of galavit acute and chronic brucellosis is accompanied by an increase, with subacute - decrease. Complex treatment with galavit in acute and chronic brucellosis favorably affects the antioxidant system. The results of the study of the antioxidant activity of galavit allow us to recommend the drug as an additional means for increasing the effectiveness of treatment of all forms of brucellosis.

The article presents the results of studying the biochemical parameters of phosphorus-calcium metabolism in patients with a metabolic syndrome associated with osteoporosis. It is shown that in patients with metabolic syndrome, phosphorus - calcium imbalance is determined already in the second stage of the metabolic syndrome, and is manifested by a decrease in the level of 1,25 (OH) 2 - vitamin D and an increase in serum parathyroid hormone concentration, which is associated with the onset of osteoporosis. In patients with metabolic syndrome 1-4 stages of the IPC decreases as the MS progresses. In patients with metabolic syndrome of the 5th stage, osteopenia / osteoporosis is more pronounced in the bones of the forearm and is associated with hyperparathyroidism.

In order to implement the evidence - based approaches for the analysis of pharmacies’ assortment we developed methodological algorithms of pharmacies categorization and cross - category analysis of drugs and other pharmaceutical products assortment by the example of state - owned pharmacies chain in Sverdlovsk region in 2012 - 2016. The results of cross - sectional, correlative, regressive, econometric and matrix analytical methods confirmed the universality of the developed algorithms which should be recommended for implementation in pharmacy chains activities.

Introduction: Histological verification of peripheral neoplasms of the lungs is an actual problem of modern oncology. The use of the method of EBUS-GS increased the possibility of establishing a diagnosis in the outpatient stage from 30 to 85% of patients. The aim of the research is to increase the percentage of verification when the ultrasound probe is located in the pathological focus, but on the border with the unchanged lung parenchyma, by the modification of the distal tip of the standard guiding sheath for "controlled" opening of the biopsies to the center of the pathological focus.